NEJM Journal Watch Infectious Diseases Top Stories of 2016

Letter to Readers |
December 28, 2016

NEJM Journal Watch Infectious Diseases Top Stories of 2016

  1. Richard T. Ellison, MD

A perspective on the most important research in the field from the past year

  1. Richard T. Ellison, MD

Dear Readers,

Below are this year's NEJM Journal Watch Infectious Diseases most important stories as selected by the editorial board.

As in 2015, major advances in HIV disease are again prominent in the list, with seminal studies showing that antiretroviral therapy prevents HIV transmission and that on-demand preexposure prophylaxis is an alternative in preventing HIV transmission. The second major topic for 2016 was the emergence of the Zika virus and the recognition of the association of the virus with both severe congenital infection and Guillain-Barré syndrome. A very concerning report for the future was the emergence of colistin-resistant bacteria that was first recognized in China; but a more hopeful study described the development of an effective single-dose vaccine for cholera.

Rounding out the list are three very practical reports that address the treatment of Lyme disease, the duration of treatment for community-acquired pneumonia, and an assessment of the impact of the harmful effects of reported beta-lactam allergy on clinical care.

Our NEJM Journal Watch Infectious Diseases Top Stories of 2016, in order of importance, are:

Prolonged Therapy for Persistent Lyme Disease Symptoms

HIV Transmission Risk Among Serodiscordant Couples: PARTNER Study Findings

Final Results from HPTN 052 Confirm That Treatment Is Prevention

Rounding Up Proof: Zika Virus and Birth Defects

Can On-Demand Preexposure Prophylaxis Prevent HIV Infection?

How Long Do We Need to Treat CAP?

Reported Beta-Lactam Allergies: More Harm Than Good?

More Evidence Linking Guillain-Barré Syndrome and Zika Virus

Single-Dose, Inactivated Oral Cholera Vaccine

Plasmid-Mediated Colistin Resistance in Animals and Humans in China

We wish you a happy holiday season.

Editor Disclosures at Time of Publication

  • Disclosures for Richard T. Ellison, MD at time of publication Consultant / Advisory board Philips Healthcare Grant / Research support Philips Healthcare

Reader Comments (3)

Seyed M Hosseini-Moghaddam Physician, Infectious Disease

Excellent resource of information

* * Hospital

Thanks for the articles

Siddharth Lath Fellow-In-Training, Internal Medicine, GOYAL Hospital, Jodhpur

An excellent resource to keep up to date.

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