Advertisement

Increased Risk for Retinal Detachment with Fluoroquinolones

Summary and Comment |
April 11, 2012

Increased Risk for Retinal Detachment with Fluoroquinolones

  1. Richard T. Ellison III, MD

A retrospective pharmacoepidemiologic study suggests that such risk is increased by 4.5-fold in current fluoroquinolone users.

  1. Richard T. Ellison III, MD

Although generally well tolerated, fluoroquinolones are known to have a destructive effect on connective tissue and have been associated with tendon rupture. Noting several reports of ocular injury linked to these antibiotics, investigators questioned whether such connective-tissue damage in the eye could predispose to retinal detachment. They explored this issue in a retrospective case-control analysis.

The researchers used records in the British Columbia Linked Health Database to identify patients who had visited an ophthalmologist in the province between 2000 and 2007. Patients who had experienced retinal detachment were each matched with 10 controls; all had 1 year of prescription drug data available. A total of 4384 patients and 43,840 controls were included in the analysis.

Risk for retinal detachment was significantly increased with current use of oral fluoroquinolones (adjusted relative risk, 4.5; 95% confidence interval, 3.6–5.7) but not with recent (prescription termination date, 1–7 days before the retinal-detachment index date) or past use. The mean time from fluoroquinolone prescription to retinal detachment was 4.8 days. No risk was seen with current use of oral β-lactam antibiotics or short-acting β-agonists, selected as pharmacologic controls. The absolute increase in risk for retinal detachment was 1 per 2500 person-years.

Comment

This study is limited in relying on administrative data both to define cases of retinal detachment and to determine prescription of fluoroquinolones. The small population of patients with recent fluoroquinolone use (12) makes it difficult to interpret the difference in risk between recent and current use. Finally, although the relative risk increase is notable, the absolute risk for retinal detachment with fluoroquinolones remains low.

Citation(s):

Your Comment

(will not be published)

Filtered HTML

  • Allowed HTML tags: <a> <em> <strong> <cite> <blockquote> <code> <ul> <ol> <li> <dl> <dt> <dd>
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Do you have any conflict of interest to disclose?
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

* Required

Reader comments are intended to encourage lively discussion of clinical topics with your peers in the medical community. We ask that you keep your remarks to a reasonable length, and we reserve the right to withhold publication of remarks that do not meet this standard.

PRIVACY: We will not use your email address, submitted for a comment, for any other purpose nor sell, rent, or share your e-mail address with any third parties. Please see our Privacy Policy.

Advertisement
Advertisement
Advertisement