Advertisement

Analysis Confirms Role of Endometriosis in Heightened Risk for Ovarian Cancer — Physician’s First Watch

Medical News |
February 22, 2012

Analysis Confirms Role of Endometriosis in Heightened Risk for Ovarian Cancer

Endometriosis increases risk for invasive ovarian cancer, an analysis of several international studies confirms, but the risk does not extend to all tumor subtypes. The results appear in the Lancet Oncology.

Researchers pooled data from 13 case-control studies performed within the Ovarian Cancer Association Consortium. In those studies, which included some 8000 women with invasive ovarian cancer and 13,000 controls, women self-reported whether they had a history of endometriosis.

Roughly 9% of women with invasive cancer reported a history of endometriosis, compared with 6% of controls. Women with a positive history were more likely to have clear-cell, endometrioid, and low-grade serous tumors, but the other two tumor subtypes (mucinous and high-grade serous) were not associated with endometriosis.

A commentator writes that because some of the tumor subtypes associated with endometriosis present at an early stage and thus could be resected, targeted screening could be considered for some women.

Reader Comments (2)

Jose Gros-Aymerich

May be the connection is thru changes in p53, a known tumor- supressor, that is abnormal in some endometriosis patients ?

Competing interests: None declared

Laurey Hallson

Does this extrapolate to post tah bso for endometriosis to primary peritoneal cancer? Just wondering...if the endometriosis is so bad to require surgery.

Competing interests: None declared

Your Comment

(will not be published)

Filtered HTML

  • Allowed HTML tags: <a> <em> <strong> <cite> <blockquote> <code> <ul> <ol> <li> <dl> <dt> <dd>
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Do you have any conflict of interest to disclose?
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

* Required

Reader comments are intended to encourage lively discussion of clinical topics with your peers in the medical community. We ask that you keep your remarks to a reasonable length, and we reserve the right to withhold publication of remarks that do not meet this standard.

PRIVACY: We will not use your email address, submitted for a comment, for any other purpose nor sell, rent, or share your e-mail address with any third parties. Please see our Privacy Policy.

Advertisement
Advertisement
Advertisement