Antidepressant Use During Pregnancy Linked to Psychiatric Disorders in Offspring — Physician’s First Watch

Medical News |
September 7, 2017

Antidepressant Use During Pregnancy Linked to Psychiatric Disorders in Offspring

By Amy Orciari Herman

Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, DFASAM

Antidepressant use during pregnancy is associated with increased risk for psychiatric disorders in offspring — but whether the association is causal remains unclear — suggests a study in The BMJ.

Using Danish registries, researchers studied over 900,000 children born to 550,000 women between 1998 and 2012. The 15-year cumulative incidence of psychiatric disorders in offspring was as follows:

  • 8% among children whose mothers didn't use antidepressants before or during pregnancy (unexposed group)

  • 12% among those whose mothers used antidepressants before but not during pregnancy

  • 14% among those whose mothers used antidepressants both before and during pregnancy

  • 15% among those whose mothers started antidepressants during pregnancy

After adjustment, risks were higher in each exposed group versus the unexposed group. Moreover, risk was higher among children whose mothers continued taking antidepressants into pregnancy than among those whose mothers stopped treatment before pregnancy (hazard ratio, 1.27).

The researchers note that the associations "may be attributable to the severity of underlying maternal disorders in combination with antidepressant exposure in utero." They caution: "Our results do not confirm causality."

Your Comment

(will not be published)

Filtered HTML

  • Allowed HTML tags: <a> <em> <strong> <cite> <blockquote> <code> <ul> <ol> <li> <dl> <dt> <dd>
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Do you have any conflict of interest to disclose?
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

* Required

Reader comments are intended to encourage lively discussion of clinical topics with your peers in the medical community. We ask that you keep your remarks to a reasonable length, and we reserve the right to withhold publication of remarks that do not meet this standard.

PRIVACY: We will not use your email address, submitted for a comment, for any other purpose nor sell, rent, or share your e-mail address with any third parties. Please see our Privacy Policy.