Associations Between Midlife Vascular Risk Factors and Dementia Seen in Cohort — Physician’s First Watch
Associations Between Midlife Vascular Risk Factors and Dementia Seen in Cohort
By Joe Elia
Vascular risk factors like smoking and hypertension, when present at midlife, are associated with higher risks for later dementia, a prospective cohort study in JAMA Neurology finds.
Some 1500 cases of dementia occurred during 25-years' surveillance among the 16,000 members of the Atherosclerosis Risk in Communities cohort. Members entered the cohort between ages 44 and 66.
The greatest risk factors for dementia were, in decreasing order of severity: age, the presence of one or more APOE e4 alleles, diabetes, current smoking at study entry, less than high school education, black race, and hypertension or prehypertension.
The authors point out that many of these risks are addressable and thus "many cases of dementia may be prevented or delayed."