Associations Between Midlife Vascular Risk Factors and Dementia Seen in Cohort — Physician’s First Watch

August 8, 2017

Associations Between Midlife Vascular Risk Factors and Dementia Seen in Cohort

By Joe Elia

Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD

Vascular risk factors like smoking and hypertension, when present at midlife, are associated with higher risks for later dementia, a prospective cohort study in JAMA Neurology finds.

Some 1500 cases of dementia occurred during 25-years' surveillance among the 16,000 members of the Atherosclerosis Risk in Communities cohort. Members entered the cohort between ages 44 and 66.

The greatest risk factors for dementia were, in decreasing order of severity: age, the presence of one or more APOE e4 alleles, diabetes, current smoking at study entry, less than high school education, black race, and hypertension or prehypertension.

The authors point out that many of these risks are addressable and thus "many cases of dementia may be prevented or delayed."

Your Comment

(will not be published)

Filtered HTML

  • Allowed HTML tags: <a> <em> <strong> <cite> <blockquote> <code> <ul> <ol> <li> <dl> <dt> <dd>
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Do you have any conflict of interest to disclose?
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

* Required

Reader comments are intended to encourage lively discussion of clinical topics with your peers in the medical community. We ask that you keep your remarks to a reasonable length, and we reserve the right to withhold publication of remarks that do not meet this standard.

PRIVACY: We will not use your email address, submitted for a comment, for any other purpose nor sell, rent, or share your e-mail address with any third parties. Please see our Privacy Policy.