The investigators measured pain only at each 3mo visit, by which point the effect of the preceding CSI would presumably have worn off. They mention this issue in their discussion, but it is unclear why they did not take steps to mitigate it. As is, the study does not adequately assess the efficacy of CSI in treatment of knee pain due to OA.
Intra-Articular Corticosteroids Show No Benefit in Knee Osteoarthritis — Physician’s First Watch
Intra-Articular Corticosteroids Show No Benefit in Knee Osteoarthritis
By Amy Orciari Herman
Intra-articular triamcinolone does not help relieve knee pain in adults with osteoarthritis — and might even lead to harm — according to a placebo-controlled trial in JAMA.
Some 140 adults with symptomatic knee osteoarthritis and ultrasound evidence of synovitis were randomized to receive intra-articular injections of either the corticosteroid triamcinolone (40 mg) or saline every 12 weeks for 2 years. At the end of the study, magnetic resonance imaging showed significantly greater knee cartilage volume loss with triamcinolone than with placebo, with no difference in knee pain between the groups.
The authors note, "It is likely that the difference in cartilage loss rates between groups was due to an adverse effect of intra-articular corticosteroids on cartilage rather than a benefit from intra-articular saline." They conclude, "These findings do not support [triamcinolone] for patients with symptomatic knee osteoarthritis."
Reader Comments (7)
SAMPLE POPULATION TOO SMALL.
Corticosteroid injections definitely do work. Disagree with study.
Prior studies of steroid injection have also shown no benefit and perhaps harm. I think we need to consider the perhaps short term benefit from the long term harm. We need to use patience
It could be that the progression of articulate wear is due to the pain relief obtained from the I/A injection of steroid which then allows patient to continue activity levels leading to further wear. This only treats the symptoms not the disease process which will continue especially medical compartment wear
Most of patients who received steroid injections, thier pain was relieved .
Study probably sponsored by big pharma. Knee injections with triamcinolone work. If they didn't the patient wouldn't request another treatment. They delay surgery and relieve symptoms.
Whoever did study is not a clinician.
Why not do retrospective study? Interview patients who have received steroid injection.