Statins Didn't Boost Muscle Risks in Patients Unaware They Were Taking Them — Physician’s First Watch
Statins Didn't Boost Muscle Risks in Patients Unaware They Were Taking Them
By Kelly Young
Statin use was not associated with muscle-related adverse events in patients who didn't know they were taking them, suggests an industry-funded Lancet study.
Over 10,000 adults at high cardiovascular risk were randomized to one of two blood-pressure lowering treatments plus either 10-mg atorvastatin or placebo. After the blinded phase of the statin arm was stopped at a median 3 years' follow-up, participants were offered open-label atorvastatin for a median of 2 years.
During the blinded phase, statin and placebo groups had similar rates of muscle-related adverse events and erectile dysfunction (all roughly 2% per annum). However, during the second phase when participants knew whether they were taking a statin, muscle-related adverse events were significantly higher in atorvastatin users than nonusers (1.26% vs. 1.00% per annum).
The authors conclude: "These results will help assure both physicians and patients that most [adverse events] associated with statins are not causally related to use of the drug and should help counter the adverse effect on public health of exaggerated claims about statin-related side-effects."