Taking Statins on Day of Coronary Bypass Linked to Lower 30-Day Mortality — Physician’s First Watch
Taking Statins on Day of Coronary Bypass Linked to Lower 30-Day Mortality
By Amy Orciari Herman
Edited by André Sofair, MD, MPH
Patients undergoing coronary artery bypass grafting (CABG) fare best when they take a statin on the day of surgery, rather than taking one earlier or not at all, according to a retrospective study in the Annals of Thoracic Surgery.
U.S. researchers reviewed the medical records of some 3000 patients who underwent primary CABG at a single institution. Nearly 60% had taken a statin 24 hours or less before surgery, 15% had done so 24–72 hours preoperatively, and the remainder had not taken a statin or had taken one more than 72 hours before surgery.
Thirty-day all-cause mortality was 1.7% with statin use 24 hours or less before CABG, 2.9% with statin use 24–72 hours preoperatively, and 3.8% with statin use 72 hours or more before surgery/no statin use. After multivariable adjustment, only statin use within 24 hours before CABG was independently associated with reduced 30-day mortality.
In terms of dosage, the equivalent of more than 20 mg atorvastatin was independently associated with reduced mortality.