Treating Mild Hypertension Might Confer Cardiovascular Benefits — Physician’s First Watch
Treating Mild Hypertension Might Confer Cardiovascular Benefits
By Kelly Young
Edited by David G. Fairchild, MD, MPH
Antihypertensive treatment in patients with grade 1 hypertension is associated with reduced cardiovascular risk, according to a meta-analysis in the Annals of Internal Medicine.
Researchers analyzed the results of trials that examined the effects of various antihypertensive regimens in roughly 15,000 patients with grade 1 hypertension (140–159/90–99 mm Hg) and no preexisting cardiovascular disease. The comparison groups either received placebo or less intensive antihypertensive regimens. Over roughly 5 years' follow-up, the mean blood pressure reduction was 3.6/2.4 mm Hg in the treatment groups versus the comparison groups.
Patients in the treatment groups had significantly lower risks for stroke (odds ratio, 0.72), cardiovascular death (OR, 0.75), and all-cause mortality (OR, 0.78). Other outcomes had nonsignificant risk reductions.
The authors say their results "suggest that blood pressure reduction is likely to provide benefit among patients with grade 1 hypertension and that these benefits could be substantial."