Using the word progesterone, without quantification, to cover all forms of synthetic progestins and bio-identical progesterone does great harm to women. Chemically they are totally different molecules whose actions in women's bodies are completely different.
MOST IMPORTANTLY, the research quantifying the two types of formulations (synthetic vs bio-identical) in a double -blind placebo research design..HAS NEVER been undertaken..you need to ask WHY has this research never been attempted?
Formulations of HRT that use Estrogen (synthetic) and bio-identical progesterone are almost as heart-protective as Estrogen alone.(PEPI Trial, 1995)
Synthetic progestins negate this heart protective effect of Estrogen. Yet the media continues to publish that HRT is not heart-protective.
Synthetic progesTIN (as opposed to bio-identical progesterone) has been shown not only to be unfriendly to the heart but to be carcinogenic in many well-designed European research studies as well as a few American studies. The time has come for your publication and other media sources to start making this distinction so that women and their Gynecologists can understand risk distinctions.
A simple google search can inform of this distinction.(happy to provide you with a list of research studies to back-up my pronouncements)
Since that landmark PEPI study that showed that estrogen with bio-identical progesterone is heart-protective ,almost to the point of estrogen alone,, we have learned of other deleterious effects of synthetic progestins and for the life of me I cannot understand any physician prescribing it knowing what the researchers know.
The above research does not even inform as the the type of progesterone/progestin used in this study..yet the progestin is the culprit in all of this controversy, not the estrogen. These recommendations are incorrect ,misleading and very harmful to women.