Estradiol(E) might be independent regulator of hemoglobin (Hb) in elderly men (J.Clin.Endocrinol.Metab.2014)On the other hand,the association between Hb and testosterone (T) was no longer significant. High level of serum E was associated with an elevated risk of stroke (a twofold excess risk of stroke), T was not related to the risk of stroke in elderly men (Neurology,2007).Check E Before Considering T, that is the guestion. Dr. V KANTARIYA MD
FDA: Risk for Venous Thromboembolism with All Testosterone Products — Physician’s First Watch
FDA: Risk for Venous Thromboembolism with All Testosterone Products
By Kristin J. Kelley
The FDA is requiring an expanded label change to all approved testosterone products to warn of the increased risk for venous thromboembolism. Labels currently address the risk for clots associated with polycythemia caused by testosterone treatment.
The action follows reports of blood clots in testosterone users unrelated to polycythemia. The agency says the warning is not related to an ongoing investigation announced in January about possible cardiovascular risks associated with testosterone treatment.
Reader Comments (5)
Like any risk mentioned in the pdr I think it's crucial to have available the percentage risk for any side effect in counseling patients with more than qualitative risk.
I am happy to see this risk acknowledged and addressed. The increasing number of older men using testosterone products and undergoing surgeries, from prostatectomy to hip and knee replacement, makes this association demand increased attention to perisurgical VTE prophylaxis, as well as to prophylaxis during hospitalizations for medical illness.
Interesting and topical research in view of the current wide promotion of testosterone.