Very wise advice,although somewhat late
FDA Reminder: Do Not Prescribe High-Dose Acetaminophen Products — Physician’s First Watch
FDA Reminder: Do Not Prescribe High-Dose Acetaminophen Products
By Kristin J. Kelley
The FDA has issued a reminder that physicians should not prescribe combination drug products containing more than 325 mg of acetaminophen per pill, as this dose increases the risk for severe liver damage.
The agency asked manufacturers in 2011 to limit acetaminophen doses by January 14, 2014, and issued a MedWatch safety alert earlier this year geared toward physicians.
Reader Comments (2)
It makes no sense to limit the dose of APAP at the same number for a normal 200 lb person as a normal 100 lb person. The liver, where APAP is detoxified, of one, is significantly larger than the other. There must be factors other than size affecting detoxification. These factors must be in the individual's phenome, either hereditary or acquired. There are people who can take a single oral dose of 20 grams and do well, and people who become ill with 2 grams, PO. Taking APAP daily is another matter. Here, "acetaminophen autoprotection" comes into play where the % glutathione derivative (benign) is increased, the sulfate derivative remains the same (benign), and the quinone derivative (toxic component) decreases. Some of the APAP is not detoxified. Kidney toxicity may become an issue. There is ample science regarding the pathophysiology created by APAP, yet I don't see any of this science applied to clinical practice. Where are the "Translational Medicine" voices?