Alzheimer's-Related Gene Variant Particularly Risky for Women — Physician’s First Watch
Alzheimer's-Related Gene Variant Particularly Risky for Women
By Joe Elia
The genetic polymorphism APOE4 is associated with a higher risk for Alzheimer disease among female carriers than among males, according to an Annals of Neurology article.
Among healthy seniors, women with the APOE4 variant were nearly twice as likely as noncarriers to develop mild cognitive impairment or Alzheimer's, while male carriers were only at slightly increased risk. Among those with mild cognitive impairment, on the other hand, both male and female carriers of APOE4 were at elevated risk for Alzheimer's; the risk difference between the sexes did not achieve statistical significance.