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In Barrett's with Low-Grade Dysplasia, Radiofrequency Ablation Reduces Progression — Physician’s First Watch

Medical News |
March 26, 2014

In Barrett's with Low-Grade Dysplasia, Radiofrequency Ablation Reduces Progression

By Joe Elia

Radiofrequency ablation, a standard of care in Barrett esophagus with high-grade dysplasia, produces a lower rate of progression in the presence of confirmed low-grade dysplasia, according to a JAMA study.

Researchers at several European centers randomized 140 patients with Barrett's with confirmed low-grade dysplasia to either radiofrequency ablation or endoscopic surveillance. The trial was stopped early after an interim analysis, when all patients had been followed for at least 2 years, with a median follow-up of 3 years.

The ablation group had a significantly lower rate of progression to either high-grade dysplasia or adenocarcinoma than the endoscopic surveillance group (1.5% vs. 26.5%). Ablation was also associated with less progression to adenocarcinoma (1.5% vs. 8.8%).

An editorialist writes that the results support ablation "for carefully selected patients" with confirmed low-grade dysplasia.

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