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Loss of a Protective Protein Linked to Alzheimer's — Physician’s First Watch

Medical News |
March 20, 2014

Loss of a Protective Protein Linked to Alzheimer's

By Joe Elia

A protein that protects neurons against oxidative stress and amyloid beta-protein toxicity goes missing in mild cognitive impairment and Alzheimer disease, according to a study in Nature.

The protein, abbreviated as REST, was measured in the prefrontal cortex regions of young adults and elderly subjects without Alzheimer's. As expected, REST levels were low in the young and rose with age. When the brains of patients with mild cognitive impairment or Alzheimer's were examined, the REST levels in the nuclei of their neurons were dramatically lower than those among the healthy, non-impaired aged.

Commentators wonder whether stimulating REST activity might prevent neurodegeneration. They say that the results provide "the first detailed investigation of molecular markers in the brain that differentiate between populations of the young, the aged and those with Alzheimer's."

Reader Comments (1)

Dr Rehana Other, Endocrinology, FUUAST ( University) Karachi Pakista

This missing Protein is present in which diet, or how we can protect our-self, by doing any exercising activity ?

Regards.
Dr Rehana

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