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Blood Test Shows Early Promise in Identifying People at Risk for Alzheimer Disease — Physician’s First Watch

Medical News |
March 10, 2014

Blood Test Shows Early Promise in Identifying People at Risk for Alzheimer Disease

By Kelly Young

An experimental blood test has used 10 phospholipid biomarkers to accurately predict preclinical Alzheimer disease in cognitively normal adults, according to a research letter published in Nature Medicine.

Researchers tested blood samples from community-dwelling adults aged 70 and older. Three years later, 53 had amnestic mild cognitive impairment or mild Alzheimer's, 18 of whom had developed their impairment over the course of the study. Blood test results for these adults were matched with those of 53 cognitively normal participants.

The researchers identified 10 different metabolites that were depleted in patients who later became impaired. In a validation phase, the test was over 90% accurate in predicting which people would develop mild cognitive impairment or Alzheimer's within 2 to 3 years.

The authors emphasize that their panel requires external validation before it is ready for clinical use.

Reader Comments (9)

Dr. V Kantariya MD Physician, Family Medicine/General Practice

Can Alzheimer Disease(AD) Be Prevented? Only based on a earlly diagnosis of AD in clinically asymptomatic elders. Combining diagnostic markers is the most useful approach to AD diagnosis.This clinical study is of vital importance.

Chirag Mistry Fellow-In-Training, Pharmacology/Pharmacy, BMC

Good One

NORMAN WILSON

Is there a current clinical study, and, if so, when and where?

alfredo leiser md Physician, Gastroenterology, retired

very interesting, but, what will we do with this information for the specific patient ?

Gail Giltner, CFNP Other Healthcare Professional, Family Medicine/General Practice, WellSpring Family Practice

My question is what would be the testing criteria along with o.k. now what do we do with the information?

Dr Manish kumar Physician, Rheumatology, Patna Bihar India

Quite original , may change the course and plan of management in due course of this debilitating curse

agustin a calderon md Physician, Family Medicine/General Practice, retired

if this is the case that metabolites are markers for non clinical seems very positive. as you say external validation must be conducted for early detection.

frederick schnure Physician, Gastroenterology, primacare, pc

helpful, general interest topic

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