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Vitamin D Supplementation Associated with Improved LDL Cholesterol Among Postmenopausal Women — Physician’s First Watch

Medical News |
March 10, 2014

Vitamin D Supplementation Associated with Improved LDL Cholesterol Among Postmenopausal Women

By Amy Orciari Herman

Postmenopausal women who gain elevated serum 25-hydroxyvitamin D3 through supplementation see reductions in LDL cholesterol, according to a study in Menopause.

Researchers measured lipids among some 600 Women's Health Initiative participants who'd been randomized to receive either daily vitamin D (400 IU) plus calcium (1000 mg), or placebo. At 2 years, the mean serum vitamin D level was significantly higher in the supplement versus placebo group (24.3 vs. 18.2 ng/mL). Further, supplement recipients had a 4.5-mg/dL decrease in LDL cholesterol relative to placebo recipients — an effect mediated by serum vitamin D levels.

The researchers conclude: "Although further studies are needed to determine whether these findings translate into clinically meaningful results, this should be viewed as a reminder that women at higher risk for 25OHD3 deficiency should consider supplementation" with calcium and vitamin D.

Reader Comments (1)

Carol Vassar, MD Physician, Internal Medicine, private practice

decreased LDL is an intermediate endpoint just like the elevation of HDL is an intermediate endpoint. Reduction in ASCVD or improvement in longevity is the endpoint that we need to be able to make any decisions of clinical management.
So, interesting, but that is all we can say about it.

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