A Second Infant Reportedly Cleared of HIV After Early Therapy — Physician’s First Watch
A Second Infant Reportedly Cleared of HIV After Early Therapy
By Joe Elia
A California baby is apparently the second case of an infant infected perinatally with HIV and showing no signs of infection after beginning early antiretroviral therapy. Details have been presented at the Conference on Retroviruses and Opportunistic Infections. The presentation also updates the progress of the earlier case from Mississippi.
The California baby was started on a three-drug antiretroviral regimen at 4 hours of age. The viral load was at undetectable levels by 11 days of age. Now 9 months old, the baby remains on antiretroviral maintenance therapy and is seronegative.
The Mississippi baby, now 41 months old, has been off antiretroviral therapy for almost 2 years. The child remains HIV seronegative.
Asked to comment, Paul Sax, author of the NEJM Journal Watch blog "HIV and ID Observations," wrote that the clinical implications of this case — most notably, whether the baby is in fact cured of HIV — remain uncertain since the baby is still on antiretroviral therapy.