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Oophorectomy Reduces Cancer Risk, Mortality in Women with BRCA Mutations — Physician’s First Watch
Oophorectomy Reduces Cancer Risk, Mortality in Women with BRCA Mutations
By Joe Elia
Women with BRCA1 or 2 mutations who undergo oophorectomy have dramatically reduced risks for all-cause mortality and for cancers of the ovaries, fallopian tubes, or peritoneum, according to a Journal of Clinical Oncology study.
Researchers followed some 5800 women with a mutation in either gene for an average of 5.6 years. Relative to those with intact ovaries, those who self-reported having undergone either bilateral oophorectomy or salpingo-oophorectomy had an adjusted hazard ratio for ovarian, fallopian tube, or peritoneal cancer of 0.20. Their hazard ratio for all-cause mortality was 0.23.