Leukemia Succumbs to Patients' Own T Cells — Physician’s First Watch
Leukemia Succumbs to Patients' Own T Cells
By Joe Elia
Almost 90% of a small group of adults with relapsed or refractory acute lymphoblastic leukemia showed a complete response to treatment with autologous T cells. The cells had been given receptors for a protein on the surface of the leukemic cells.
As reported in Science Translational Medicine, most patients were well enough after treatment to be candidates for bone marrow transplantation. Some apparently suffered a side effect of the treatment — severe cytokine release syndrome — which the authors plan to curb in future patients with corticosteroids or interleukin-6 receptor blockade.
Regarding the durability of the response, the Wall Street Journal reports that of eight patients who did not undergo bone marrow transplantation, four died and four remain in remission. One patient has been in remission for more than 2 years since treatment.