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HPV Vaccination for Genital Wart Prevention: 2 Doses Almost As Good As 3 — Physician’s First Watch

Medical News |
February 12, 2014

HPV Vaccination for Genital Wart Prevention: 2 Doses Almost As Good As 3

By Amy Orciari Herman

When it comes to preventing condylomata (genital warts), two doses of the quadrivalent human papillomavirus vaccine are nearly as effective as three, a JAMA study finds.

Using national registries, researchers in Sweden followed over a million females aged 10 to 24 from 2006 through 2010. During that time, 9% received the recommended three-dose HPV vaccine series, 2% received two or one dose, and 89% received none. (Virtually all vaccinated girls received the quadrivalent vaccine, which includes protection against HPV types 6 and 11 — the strains that account for 90% of condylomata cases.)

Some 20,000 incident condylomata occurred. Three doses of HPV vaccine provided maximal protection (incident rate ratio relative to no vaccine, 0.18). However, compared with two doses, three doses prevented just 59 additional cases per 100,000 person-years — a "small difference," according to the researchers.

The researchers call for studies into whether fewer HPV vaccine doses would also be sufficient for cervical cancer prevention.

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