Most NSAIDs Not Associated with Increased Miscarriage Risk — Physician’s First Watch
Most NSAIDs Not Associated with Increased Miscarriage Risk
By Kelly Young
Exposure to nonsteroidal anti-inflammatory drugs during pregnancy is not associated with increased risk for miscarriage, according to a study in the Canadian Medical Association Journal.
Using data from a hospital in Israel, researchers evaluated 65,000 pregnancies from 2003 to 2009. Women who were dispensed nonselective NSAIDs (e.g., ibuprofen, diclofenac, naproxen) did not have increased risk for spontaneous abortion, compared with women who were unexposed (8.2% vs. 10%). In a subanalysis of individual NSAIDs, exposure to indomethacin in the first trimester was associated with increased risk for miscarriage (adjusted hazard ratio, 2.82), but the authors say this could be a case of reverse causation since the drug is indicated to treat preterm labor.