while the study is interesting and the concept of desensitization not new, i wonder how they convinced the parents that the study is safe and no child will suffer. Or where the children chosen on the basis of the severity of their intolerance?
Oral Immunotherapy Shows Promise in Children with Peanut Allergy — Physician’s First Watch
Oral Immunotherapy Shows Promise in Children with Peanut Allergy
By Kelly Young
Oral immunotherapy in children with peanut allergy is associated with a high rate of desensitization, according to a phase II trial in the Lancet.
Roughly 100 children (aged 7 to 16 years) with peanut allergy were randomized to usual care (peanut avoidance) or 26 weeks of oral immunotherapy — daily doses of peanut flour that increased over time, up to a maintenance dose of 800 mg/day. After 26 weeks, 62% of patients in the treatment group were desensitized (i.e., no reaction during a blinded food challenge of 1400 mg). No patients in the control group were desensitized. Oral itching was the most common side effect, occurring after 6% of doses. Intramuscular adrenaline was administered twice.
A commentator writes that oral immunotherapy "is not ready for clinical use." He says that more research needs to be done on short- and long-term effects, mechanism of action, outcomes, and protocols. "This must be done without added pressure or heightened expectations to quickly produce a marketable therapy."