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Featured in NEJM Journal Watch: Lack of Efficacy for Doxycycline in Stunting Aneurysm Growth — Physician’s First Watch
Featured in NEJM Journal Watch: Lack of Efficacy for Doxycycline in Stunting Aneurysm Growth
By the NEJM Journal Watch Editors
Contrary to evidence from preclinical studies, doxycycline failed to decrease growth of small abdominal aortic aneurysms in an aborted randomized trial in the Annals of Internal Medicine. Cardiologist Joel Gore writes in NEJM Journal Watch: "A medical treatment to retard abdominal aortic aneurysm enlargement and obviate or delay the need for surgical repair remains elusive."