Odd, Fatal Hematological Manifestation of Dengue Fever Detailed in MMWR — Physician’s First Watch
Odd, Fatal Hematological Manifestation of Dengue Fever Detailed in MMWR
By Joe Elia
This week's MMWR reminds clinicians to be vigilant for dengue and presents a rare complication of the mosquito-borne disease, which has most often been acquired during travel outside the U.S.
The authors present a case of dengue that was apparently acquired by a Texas woman who'd recently traveled in New Mexico. On the basis of serologic studies she was at first diagnosed as suffering West Nile virus infection. Hemophagocytic lymphohistiocytosis — a rare complication of dengue — developed and the patient died. A bone marrow biopsy showed macrophages containing ingested red cells.
MMWR's editors warn that West Nile and dengue may have cross-reactive antibodies on serologic tests, and that suspected West Nile cases, particularly in people with recent travel to the tropics, should be evaluated for dengue. They ask that all suspected dengue cases be reported to state and local health departments.