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Vitamin E Supplementation Linked to Better Functional Outcomes in Alzheimer's Patients — Physician’s First Watch

Medical News |
January 2, 2014

Vitamin E Supplementation Linked to Better Functional Outcomes in Alzheimer's Patients

By Kelly Young

Vitamin E supplementation is associated with slower functional decline among patients with mild-to-moderate Alzheimer disease, according to a JAMA study.

Over 600 Veterans Affairs patients with mild-to-moderate Alzheimer's who were taking an acetylcholinesterase inhibitor were randomized to receive synthetic vitamin E (2000 IU/day) plus placebo, memantine plus placebo, vitamin E plus memantine, or double placebo.

After a mean follow-up of roughly 2 years, patients assigned to vitamin E alone had better scores on their ability to perform activities of daily living, translating to a 6-month delay in disease progression, compared with patients given placebo. Patients taking memantine — either alone or with vitamin E — did not see a similar benefit. Neither treatment was associated with increased risk for adverse events, including all-cause mortality.

Editorialists stress the importance of not extrapolating the current findings to the "use of vitamin E at different dosages, among people with different [Alzheimer's] severity levels, or in combination with different agents."

Reader Comments (6)

FRANCA, DANIEL Physician, Cardiology, Hospital do Coração (Heart Hospital)

Every single detail that can help us to improve life quality, is worth.

NANSE NATHAN Other Healthcare Professional, Other, fletcher Allen Health Care

Even if it's a placebo effect, anything that might help should be tried.

Anita Balodis MD Physician, Preventive Medicine, Office

There many forms of vit E. what form did they use?

VLASTA RYCHTEROVA Physician, Pathology, Bioptic laboratory Prague

Everything that can improve the prognosis of Alzheimer patients is worth to try

GERTY HUYSAMEN

We put my Mom - Daphne de Bruyn on Vit E 1000mg x 2 per day and in 2weeks could see a difference - Thanks to Dr Delport from Canada (used to be SA- Welkom FS) histo advise. Her actions and behavior/memory is much better. Time will also tell know.

Gary Raffel Physician, Internal Medicine, Solo, office based

The vitamin E story remains one of the good, the bad, the ugly. I have put the vitamin E on the shelf until multiple studies with larger numbers can tease out the benefits of supplemental tocopherol use. Good money a follow up group of studies will not be as promising.

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