Advertisement

Quadrivalent Flu Vaccine Shows Effectiveness in Children — Physician’s First Watch

Medical News |
December 12, 2013

Quadrivalent Flu Vaccine Shows Effectiveness in Children

By Joe Elia

An influenza vaccine incorporating two "A" and two "B" virus lineages — as opposed to the usual two "A" and one "B" formulation — shows effectiveness in young children, especially in preventing moderate-to-severe illness, according to a New England Journal of Medicine study. It was conducted by the vaccine maker.

Researchers randomized some 5000 children between the ages of 3 and 8 to receive either the quadrivalent vaccine or, as a control, a hepatitis A vaccine. Cases of influenza were confirmed by polymerase chain reaction.

Influenza developed in 2.4% of quadrivalent vaccine recipients and 5.7% of controls, giving the vaccine an estimated efficacy of 59%. Its efficacy against moderate-to-severe disease was 74%. Pain at the injection site was more common in quadrivalent recipients.

The added "B" lineage (B/Yamagata) was not circulating widely in the countries where the vaccine was tested, so its efficacy against that strain couldn't be assessed.

Your Comment

(will not be published)

Filtered HTML

  • Allowed HTML tags: <a> <em> <strong> <cite> <blockquote> <code> <ul> <ol> <li> <dl> <dt> <dd>
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Do you have any conflict of interest to disclose?
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

* Required

Reader comments are intended to encourage lively discussion of clinical topics with your peers in the medical community. We ask that you keep your remarks to a reasonable length, and we reserve the right to withhold publication of remarks that do not meet this standard.

PRIVACY: We will not use your email address, submitted for a comment, for any other purpose nor sell, rent, or share your e-mail address with any third parties. Please see our Privacy Policy.

Advertisement
Advertisement
Advertisement