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Smoking Cessation Treatments Not Linked to Major CV Events — Physician’s First Watch

Medical News |
December 10, 2013

Smoking Cessation Treatments Not Linked to Major CV Events

By Kelly Young

Smoking cessation therapies are not associated with increased risk for serious cardiovascular events, according to a meta-analysis in Circulation.

Researchers examined 63 randomized controlled trials that assessed varenicline, bupropion, or nicotine replacement therapy in some 30,000 participants.

After a median 12 weeks' treatment and 12 months' follow-up, bupropion and varenicline were not associated with increased cardiovascular risk. Although replacement therapy was tied to elevated risk for all cardiovascular events compared with placebo (relative risk, 2.29), most of this risk could be explained by lower-level CV events, such as tachycardia and arrhythmia. Meanwhile, bupropion was associated with a reduced risk for the combined outcome of stroke, myocardial infarction, and cardiovascular death (RR, 0.45).

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