Meta-Analysis Finds No Causal Relation Between Vitamin D Status and Health — Physician’s First Watch
Meta-Analysis Finds No Causal Relation Between Vitamin D Status and Health
By Amy Orciari Herman
Vitamin D's frequently observed association with health conditions is not causal, according to a meta-analysis in the Lancet Diabetes & Endocrinology.
Researchers analyzed data from 290 prospective cohort studies and 172 randomized trials examining the relation between serum concentrations of 25-hydroxyvitamin D and nonskeletal health conditions. In the cohort studies, higher 25 (OH)D concentrations generally were associated with lower likelihood of cardiovascular disease, lipid disorders, glucose metabolism disorders, infectious diseases, multiple sclerosis, mood disorders, and total mortality. However, the randomized trials showed no effect of vitamin D supplementation on these outcomes.
The authors conclude that low serum vitamin D may simply be a marker of poor health. They speculate that low concentrations "could be the result of inflammatory processes involved in the occurrence and progression of disease."