Is APOE a Risk Factor for Cerebrovascular Injury?
Neurology Summary and Comment
These two studies focus on the role of apolipoprotein E (APOE) genotype in both the risk for stroke and the risk for poor recovery from . . .
By Warren J. Strittmatter, MD
February 9, 2006
Covering:
Heyer EJ et al., Neurology 2005 Dec 13; 65:1759-63
Sturgeon JD et al., Stroke 2005 Nov; 36:2484-6
Predictors of Good Outcome After rt-PA for Ischemic Stroke
Neurology Summary and Comment
Clinicians who administer rt-PA for acute stroke often wonder who benefits. In this study, researchers asked what factors predispose to a good outcome at 24 . . .
By Rafael Llinas, MD
February 9, 2006
Covering:
Saposnik G et al., Neurology 2005 Oct 25; 65:1169-74
Blood Pressure in Acute Stroke: How Low Is Too Low?
Neurology Summary and Comment
Previous research has suggested that low blood pressure is detrimental in patients with acute ischemic stroke (Neurology 2003; 61:1047 and Ann Emerg Med 2003 . . .
By Allan S. Brett, MD
February 9, 2006
Covering:
Stead LG et al., Neurology 2005 Oct 25; 65:1179-83
Driving Simulator Training Helps Stroke Patients
Neurology Summary and Comment
Researchers at a rehabilitation facility tested the ability of driving-simulator training to improve the on-road driving performance of 83 stroke patients younger than 75. Within . . .
By Germaine L. Odenheimer, MD
February 9, 2006
Covering:
Akinwuntan AE et al., Neurology 2005 Sep 27; 65:843-50
Features and Outcomes of Ischemic Stroke in Tuberculous Meningitis
Neurology Summary and Comment
The authors prospectively studied 40 patients diagnosed with definite or probable tuberculous meningitis (TBM) who presented consecutively over a 6-year period to determine features of . . .
By Pierre L. A. Bill, MBBCh, FCP (SA), FRCP (UK)
February 9, 2006
Covering:
Chan KH et al., Cerebrovasc Dis 2005 Jun; 19:391-5
The Burden of Acute Vascular Events: A Broad Look
Cardiology Summary and Comment
Data from the Oxford Vascular Study suggest that cerebrovascular events are more common than coronary events.
By Beat J. Meyer, MD
January 26, 2006
Covering:
Rothwell PM et al. for the Oxford Vascular Study., Lancet 2005 Nov 19; 366:1773-83
Post-MI Strokes: A 20-Year Study
Cardiology Summary and Comment
Stroke incidence was high during the first 3 years after myocardial infarction, particularly in the first month.
By Joel M. Gore, MD
January 26, 2006
Covering:
Witt BJ et al., Ann Intern Med 2005 Dec 6; 143:785-92
Mitral Annular Calcification and Stroke
Cardiology Summary and Comment
The more diagnostic imaging we do, the more aware we become of less well-known stroke risk factors.
By Joel M. Gore, MD
January 19, 2006
Covering:
Kizer JR et al., Stroke 2005 Dec; 36:2533-7
Barnett HJM., Stroke 2005 Dec; 36:2523-5
Warfarin Reversal: Another Door-to-Drug Time Goal
Emergency Medicine Summary and Comment
Free
Shorter times to administration of vitamin K or fresh frozen plasma increase the chance for successful reversal of anticoagulation in patients with warfarin-associated intracerebral hemorrhage.
By Daniel J. Pallin, MD, MPH
January 17, 2006
Covering:
Goldstein JN et al., Stroke 2006 Jan; 37:151-5
Transient Ischemic Attack with Infarction
Neurology Summary and Comment
Free
TIAs with and without infarctions may differ in important ways, but both require emergency care.
By Henry J.M. Barnett, MD
January 12, 2006
Covering:
Ay H et al., Ann Neurol 2005 May; 57:679-86
Long-Term Outcomes in Patients with Lacunar Infarcts
Neurology Summary and Comment
These authors followed 81 patients with lacunar stroke for 5 years to assess functional and cognitive outcomes. Data came from periodic clinical examinations and MRI . . .
By José G. Merino, MD
January 12, 2006
Covering:
Appelros P et al., Cerebrovasc Dis 2005 Jul; 20:34-40
The Search for Unique Clinical Features of aPL-Positive Stroke
Neurology Summary and Comment
Antiphospholipid antibodies (aPL) have been associated with both venous and arterial thromboembolic events. Since their first description 100 years ago, aPLs have been studied extensively . . .
By Steven R. Levine, MD
January 12, 2006
Covering:
Terashi H et al., Cerebrovasc Dis 2005 Jun; 19:384-90
Low Use of t-PA for Acute Ischemic Stroke Nationwide: A Wake-Up Call
Neurology Summary and Comment
In 1995, the National Institute of Neurological Disorders and Stroke trial showed intravenous tissue plasminogen activator (IV t-PA) to be effective in treating ischemic stroke . . .
By Yousef M. Mohammad, MD, MSc
January 12, 2006
Covering:
Qureshi AI et al., Neurosurgery 2005 Oct; 57:647-54
Blood-Flow Physiology in Stroke and Stroke Recovery
Neurology Summary and Comment
Jean-Claude Baron reviews the last quarter century of advances in our understanding of ischemic stroke, including his own substantial contributions. Baron coined the term “misery . . .
By Randolph S. Marshall, MD, MS
January 12, 2006
Covering:
Baron J-C., Cerebrovasc Dis 2005 Sep; 20:154-63
