Stenting Versus Endarterectomy for Carotid Artery Stenosis: What Are the Trade-Offs?
Cardiology
Summary and Comment
Free
Mid-term CREST findings indicate that surgery is more effective for stroke prevention, but stenting has some advantages.
By Howard C. Herrmann, MD
June 4, 2010
Covering:
Brott TG et al. for the CREST Investigators., N Engl J Med 2010 May 26
Davis SM and Donnan GA., N Engl J Med 2010 May 26
Herpes Zoster Ophthalmicus and Risk for Stroke
Neurology
Summary and Comment
Ophthalmic-distribution zoster is a risk factor for stroke during a one-year follow-up period.
By Don Gilden, MD
June 1, 2010
Covering:
Lin H-C et al., Neurology 2010 Mar 9; 74:792
Nagel M and Ortiz GA., Neurology 2010 Mar 9; 74:788
No Benefit from Intravenous Alteplase When Given After 4.5 Hours of Stroke Onset
Emergency Medicine
Summary and Comment
Free
Risk for favorable outcomes decreases with increasing time to treatment from stroke onset, and, after 4.5 hours, alteplase treatment might increase mortality.
By Kristi L. Koenig, MD, FACEP
May 28, 2010
Covering:
Lees KR et al., Lancet 2010 May 15; 375:1695
Saver JL and Levine SR., Lancet 2010 May 15; 375:1667
Thrombolysis After Ischemic Stroke: Earlier Is Much Better
General Medicine
Summary and Comment
Net benefit was undetectable when alteplase was given more than 4.5 hours after stroke onset.
By Bruce Soloway, MD
May 27, 2010
Covering:
Lees KR et al., Lancet 2010 May 15; 375:1695
Saver JL and Levine SR., Lancet 2010 May 15; 375:1667
Diagnosis and Management of Thoracic Aortic Disease
Cardiology
Clinical Practice Guideline Watch
Experts from many disciplines provide welcome guidance about frequently asymptomatic conditions with potentially catastrophic outcomes.
By Beat J. Meyer, MD
May 26, 2010
Covering:
Hiratzka LF et al., J Am Coll Cardiol 2010 Apr 6; 55:e27
The Anatomical Basis of Gerstmann Syndrome
Neurology
Summary and Comment
Is it a disconnection syndrome?
By Kenneth M. Heilman, MD
May 25, 2010
Covering:
Rusconi E et al., Ann Neurol 2009 Nov; 66:654
Is Tissue Plasminogen Activator Safe in Patients with "Stroke Mimics"?
General Medicine
Summary and Comment
It's unlikely to cause harm in these patients.
By Allan S. Brett, MD
May 20, 2010
Covering:
Chernyshev OY et al., Neurology 2010 Apr 27; 74:1340
Does Pneumococcal Vaccination Protect Against Cardiovascular Events?
Infectious Diseases
Summary and Comment
In a prospective cohort study involving nearly 85,000 men, vaccination did not reduce risk for myocardial infarction or stroke.
By Richard T. Ellison III, MD
May 19, 2010
Covering:
Tseng HF et al., JAMA 2010 May 5; 303:1699
Madjid M and Musher DM., JAMA 2010 May 5; 303:1751
Validation of the ABCD2 Score for Predicting Stroke Risk After Transient Ischemic Attack
Emergency Medicine
Summary and Comment
Free
An ABCD2 score >2 is associated with significantly increased risk for stroke within 90 days.
Magnesium Infusion Might Improve Outcomes After Subarachnoid Hemorrhage
Emergency Medicine
Summary and Comment
The incidences of delayed ischemic infarction and vasospasm were significantly reduced in patients treated with magnesium, compared with controls.
By Kristi L. Koenig, MD, FACEP
April 30, 2010
Covering:
Westermaier T et al., Crit Care Med 2010 May; 38:1284
Taccone FS., Crit Care Med 2010 May; 38:1382
Is Tissue Plasminogen Activator Harmful in Patients Who Ultimately Do Not Have Acute Ischemic Stroke?
Emergency Medicine
Summary and Comment
This study's findings suggest not.
Midline Shift or Herniation in Patients with Subarachnoid Hemorrhage and Normal Neurological Exams
Emergency Medicine
Summary and Comment
Free
In a retrospective study, 5% of patients with spontaneous SAH and normal neurological exams had computed tomographic findings that contraindicated lumbar puncture.
Awareness and Treatment of Atrial Fibrillation
Cardiology
Summary and Comment
Blacks with AF are less likely than whites both to know about their condition and to receive warfarin for it.
By Joel M. Gore, MD
April 14, 2010
Covering:
Meschia JF et al., Stroke 2010 Apr 1; 41:581
Women from JUPITER . . .
Cardiology
Summary and Comment
. . . benefited from rosuvastatin as much as men did.
By JoAnne M. Foody, MD
April 14, 2010
Covering:
Mora S et al., Circulation 2010 Mar 9; 121:1069
Proton-Pump Inhibitors and Clopidogrel: Important Interaction?
General Medicine
Summary and Comment
Coronary heart disease patients who received both drugs experienced fewer hospitalizations for gastrointestinal bleeding than did those who received clopidogrel alone.
Carotid Stenting vs. Endarterectomy: Coming into Focus
Cardiology
Summary and Comment
Free
Findings from a large clinical trial and magnetic resonance imaging substudy strengthen the case for endarterectomy as the preferred treatment for carotid artery stenosis.
By Beat J. Meyer, MD
April 7, 2010
Covering:
ICSS Investigators., Lancet 2010 Mar 20; 375:985
Bonati LH et al., Lancet Neurol 2010 Apr; 9:353
Rothwell PM., Lancet 2010 Mar 20; 375:957
Oral Contraceptive Use Affects Migraines
Women's Health
Summary and Comment
Combination oral contraceptives influenced frequency and severity of migraines but not other headache types.
Silent Cerebral Embolism After Transcatheter Aortic-Valve Implantation
Cardiology
Summary and Comment
Two studies from Germany show that it is common.
By Howard C. Herrmann, MD
March 17, 2010
Covering:
Kahlert P et al., Circulation 2010 Feb 23; 121:870
Adams HP Jr., Circulation 2010 Feb 23; 121:846
Ghanem A et al., J Am Coll Cardiol 2010 Feb 24
Primary Prevention of Cardiovascular Events with Aspirin
General Medicine
Summary and Comment
No benefit was observed in a group at high risk for vascular disease.
By Thomas L. Schwenk, MD
March 11, 2010
Covering:
Fowkes FGR et al., JAMA 2010 Mar 3; 303:841
Berger JS., JAMA 2010 Mar 3; 303:880
Do Folic Acid and B12 Cause Cancer?
Neurology
Summary and Comment
Excess cancer incidence and cancer mortality occurred in a follow-up of two clinical trials of folic acid and B12 supplements for cardiovascular risk reduction.
By Laurence J. Kinsella, MD
March 9, 2010
Covering:
Ebbing M et al., JAMA 2009 Nov 18; 302:2119
Endarterectomy vs. Stenting for Carotid Artery Stenosis
General Medicine
Summary and Comment
Periprocedural risk was lower with endarterectomy, but longer-term risk was similar with either procedure.
Statins and Stroke Prevention: Is It All About the Cholesterol?
Cardiology
Summary and Comment
In a meta-analysis of statin and nonstatin treatment trials, stroke reduction was proportional to the lipid-lowering effect of the intervention.
By JoAnne M. Foody, MD
March 3, 2010
Covering:
De Caterina R et al., J Am Coll Cardiol 2010 Jan 19; 55:198
Don't Forget to Use Them After Stroke
Psychiatry
Summary and Comment
Free
An antidepressant improves memory in nondepressed poststroke patients.
By Jonathan Silver, MD
February 22, 2010
Covering:
Jorge RE et al., Arch Gen Psychiatry 2010 Feb; 67:187
The Role of the Prefrontal Cortex in Contextual Processing
Neurology
Summary and Comment
A study of event-related potentials in patients with prefrontal lesions demonstrates the region's critical role in processing contextual information.
By Kirk R. Daffner, MD
February 16, 2010
Covering:
Fogelson N et al., Brain 2009 Nov; 132:3002
Diffusion-Weighted Imaging in Normal-Pressure Hydrocephalus
Neurology
Summary and Comment
Can DWI differentiate reversible changes caused by NPH from irreversible microangiopathic changes within periventricular white matter?
By Joshua P. Klein, MD, PhD
February 9, 2010
Covering:
Tullberg M et al., Acta Neurol Scand 2009 Oct; 120:226