HIV Transmission Among Serodiscordant Couples
Potential risk factors identified in this study from China include inconsistent condom use, relatively frequent sex, and lack of a switch to second-line antiretroviral therapy.
HIV Prevalence Alarmingly High Among MSM in the U.S.
In a 2008 survey, 19% of men who have sex with men tested HIV-positive. More than 40% of these men did not know they were infected.
By Carlos del Rio, MD
November 1, 2010
Covering:
Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2010 Sep 24; 59:1201
Sexual Risk Behavior in Older HIV-Positive Individuals
In a survey of HIV-positive people aged 50 and older, half were sexually active — and of these, 14% reported recent unprotected high-risk sex with a serodiscordant partner.
Suppressed but with Side Effects — What Actually Happened
HIV/AIDS Clinical Care Antiretroviral Rounds
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Find out how our latest Antiretroviral Rounds case was actually managed.
A Snapshot of the HIV Epidemic in France
Incidence rates are declining in the overall population, but they remain alarmingly high among men who have sex with men.
By Carlos del Rio, MD
October 25, 2010
Covering:
Le Vu S et al., Lancet Infect Dis 2010 Oct; 10:682
Suppressed but with Side Effects — The Experts Weigh In
HIV/AIDS Clinical Care Antiretroviral Rounds
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Two experts describe how they would manage a patient who is experiencing adverse effects on a cumbersome but otherwise successful antiretroviral regimen, with no resistance testing available.
Gender Makes Little Difference in Antiretroviral Response
In a large trial, investigators found few meaningful differences between men and women with respect to ART efficacy and toxicity but had trouble retaining female participants.
By Abigail Zuger, MD
October 8, 2010
Covering:
Currier J et al., Ann Intern Med 2010 Sep 21; 153:349
Suppressed but with Side Effects — Now What?
HIV/AIDS Clinical Care Antiretroviral Rounds
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You inherit a patient who is experiencing adverse effects on a cumbersome but otherwise successful regimen, but no resistance testing is available. How do you manage his care?
Human Papillomavirus Vaccine Appears Safe in HIV-Positive Men
It also elicits antibody against all vaccine strains.
By Abigail Zuger, MD
September 20, 2010
Covering:
Wilkin T et al., J Infect Dis 2010 Oct 15; 202:1246
Do Antiviral Drugs Taken During Pregnancy Cause Birth Defects?
Women's Health Summary and Comment
First-trimester use of acyclovir was not associated with excess risk for major birth defects.
By Anna Wald, MD, MPH
September 16, 2010
Covering:
Pasternak B and Hviid A., JAMA 2010 Aug 25; 304:859
Mills JL and Carter TC., JAMA 2010 Aug 25; 304:905
Syphilis and HIV: The Intersection of Two Epidemics
A comprehensive review of the epidemiology, clinical presentation, diagnosis, treatment, and monitoring of syphilis in HIV-infected patients
Excess Mortality in Patients with Untreated HIV and High CD4 Counts
General Medicine Summary and Comment
Even in patients with robust CD4-cell counts, HIV infection confers 1-year mortality risk.
By Bruce Soloway, MD
August 24, 2010
Covering:
Study Group on Death Rates at High CD4 Count in Antiretroviral Naive Patients., Lancet 2010 Jul 31; 376:340
Test Older Sexually Active Adults for HIV
HIV infection is diagnosed late in about half of all infected adults aged 50 and older in the U.K.
Fighting Warts with Wart Vaccine
Dermatology Summary and Comment
Repeat vaccinations appeared to provide effective treatment of early vulvar intraepithelial neoplasia with small lesions.
By Mark V. Dahl, MD
August 13, 2010
Covering:
Welters MJP et al., Proc Natl Acad Sci U S A 2010 Jun 29; 107:11895
Web-Based Partner Notification for Syphilis
Infectious Diseases Summary and Comment
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Expanding syphilis case management to the Internet substantially increased the number of sex partners who were notified.
A Successful Vaginal Microbicide, at Last
General Medicine Summary and Comment
Tenofovir gel prevents some HIV infections in heterosexual women.
By Abigail Zuger, MD
August 10, 2010
Covering:
Abdool Karim Q et al., Science 2010 Jul 19
Report from the 2010 International AIDS Conference
Prevention took center stage in Vienna, as described here by the physician-editors of <$EMPH_O>Journal Watch AIDS Clinical Care<$EMPH_C>.
Syphilis Simmers Down
Most of the identified cases in a large screened population were asymptomatic.
By Abigail Zuger, MD
August 9, 2010
Covering:
Thurnheer MC et al., AIDS 2010 Jul 31; 24:1907
Efficacy of Second-Line HIV Therapy in Developing Countries
Infectious Diseases Summary and Comment
Failure of second-line therapy was linked to advanced disease at initiation of the regimen, poor adherence, and use of less-active regimens.
Treatment Simplification in HIV-Infected Patients
In patients who have virologic suppression while receiving abacavir/3TC plus ritonavir-boosted atazanavir, dropping the ritonavir does not compromise regimen potency.
Excess Mortality in Untreated HIV-Infected Patients with High CD4-Cell Counts
Infectious Diseases Summary and Comment
In a large, multinational cohort study, the death rate among such patients varied by risk group but was higher than in the general population.
By Rajesh T. Gandhi, MD
July 28, 2010
Covering:
Lodwick RK et al. for the Study Group on Death Rates at High CD4 Count in Antiretroviral Naive Patients., Lancet 2010 Jul 16
Bassett IV and Sax PE., Lancet 2010 Jul 16
Finally, an Effective Microbicide Against HIV and, Possibly, Herpes Simplex Virus Type 2: Results from CAPRISA 004
HIV/AIDS Clinical Care Summary and Comment
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A 1% tenofovir gel used intravaginally both before and after sex reduced the incidence of HIV infection among women by up to 54%.
By Frances Priddy, MD, MPH, and Carlos del Rio, MD
July 26, 2010
Covering:
Abdool Karim Q et al., Science 2010 Jul 19
New Guidelines Stress Early HIV Treatment
HIV/AIDS Clinical Care Clinical Practice Guideline Watch
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The International AIDS Society–USA is urging clinicians to treat patients when their CD4 counts drop to 500 cells/mm3 or lower — and to consider treatment even at higher CD4-cell counts.
By Abigail Zuger, MD
July 26, 2010
Covering:
Thompson MA et al., JAMA 2010 Jul 21; 304:321
Identification of New Broadly Reactive HIV-1–Specific Monoclonal Antibodies
One monoclonal antibody neutralizes >90% of worldwide circulating HIV-1 isolates.
By Dan H. Barouch, MD, PhD
July 26, 2010
Covering:
Wu X et al., Science 2010 Jul 8
Zhou T et al., Science 2010 Jul 8
Opt-Out HIV Testing in Emergency Departments: Too Little, Too Late
In a high-volume urban ED, this strategy modestly increased the number of patients with new HIV diagnoses, but most such patients already had advanced disease.
