A New Paradigm for Treating Drug-Resistant HIV
Infectious Diseases Summary and Comment
Free
Results from the POWER 1 and 2 studies at 48 weeks show that darunavir-ritonavir is efficacious against HIV resistant to older protease inhibitors.
By Rajesh T. Gandhi, MD
April 18, 2007
Covering:
Clotet B et al., Lancet 2007 Apr 7; 369:1169-78
Drugs, Sex, and HIV Infection Among MSM
An analysis of MACS data strongly suggests an increased risk for HIV seroconversion among MSM who use methamphetamine, poppers, or both.
By Carlos del Rio, MD
April 13, 2007
Covering:
Plankey MW et al., J Acquir Immune Defic Syndr 2007 Mar 30
Multidrug-Resistant HIV: A Tale of Two Transmission Events
Infectious Diseases Summary and Comment
More information about the multidrug-resistant HIV strain associated with rapid progression to AIDS in a New York City man
By Daniel J. Diekema, MD, MS
April 11, 2007
Covering:
Blick G et al., J Infect Dis 2007 May 1; 195:1250-9
Hecht FM et al., J Infect Dis 2007 May 1; 195:1239-41
Diagnosing HIV Infection: A Matter of Time
Infectious Diseases Summary and Comment
Diagnosis of HIV infection is uncommon during the first 6 months following virus acquisition; such a delay likely leads to continued transmission.
By Rajesh T. Gandhi, MD
April 11, 2007
Covering:
Schwarcz S et al., J Acquir Immune Defic Syndr 2007 Jan 1; 44:112-5
Blacks Continue to Bear a Disproportionate Burden of HIV/AIDS in the U.S.
In 2005, HIV/AIDS diagnoses were 21 times more common among black women than white women — and 7 times more common among black men than white men.
By Salim S. Abdool Karim, MD, PhD
April 9, 2007
Covering:
Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2007 Mar 9; 56:189-93
HPV Infection in U.S. Women: Who Has the Highest Prevalence?
Women's Health Summary and Comment
Among sexually active women aged 20–24 years, the prevalence of HPV infection was almost 50%.
By Wendy S. Biggs, MD
April 5, 2007
Covering:
Dunne EF et al., JAMA 2007 Feb 28; 297:813-9
Weller SC and Stanberry LR., JAMA 2007 Feb 28; 297:876-8
HSV-Suppressive Therapy Might Improve HIV Status in Dually Infected Women
Women's Health Summary and Comment
The antiviral valacyclovir reduced genital and plasma HIV RNA levels.
By Anna Wald, MD, MPH
April 5, 2007
Covering:
Nagot N et al., N Engl J Med 2007 Feb 22; 356:790-9
Corey L., N Engl J Med 2007 Feb 22; 356:854-6
Exclusive Breast-Feeding and HIV Transmission
Infectious Diseases Summary and Comment
Free
Exclusively breast-fed infants of HIV-infected mothers were less likely to be infected at 6 months than were similar infants who consumed solids or nonhuman milk.
By Mary E. Wilson, MD
April 4, 2007
Covering:
Coovadia HM et al., Lancet 2007 Mar 31; 369:1107-16
Holmes WR and Savage F., Lancet 2007 Mar 31; 369:1065-6
The HIV/AIDS Epidemic in the U.S.
Stemming the epidemic in the U.S. will require that scientifically sound prevention interventions be scaled up and strengthened.
By Carlos del Rio, MD
April 2, 2007
The Promise of Prevention: Male Circumcision and Microbicides
Data at the 14th Retrovirus Conference highlight the protective potential of male circumcision and, to a lesser extent, microbicides.
By Carlos del Rio, MD
April 2, 2007
Human Papillomavirus Prevalence in the U.S.
It’s even higher than we thought.
By Peggy Sue Weintrub, MD
March 28, 2007
Covering:
Dunne EF et al., JAMA 2007 Feb 28; 297:813-9
Acceptance of HPV Vaccination
Most California parents supported vaccinating their daughters.
By M. Susan Jay, MD
March 28, 2007
Covering:
Constantine NA and Jerman P., J Adolesc Health 2007 Feb; 40:108-15
Kahn JA., J Adolesc Health 2007 Feb; 40:101-3
Birth Defects and ART
Infectious Diseases Summary and Comment
In a large prospective cohort study, ART during pregnancy was not associated with an overall increase in birth defects.
By Rajesh T. Gandhi, MD
March 28, 2007
Covering:
Watts DH et al., J Acquir Immune Defic Syndr 2007 Mar 1; 44:299-305
Do HIV Testing Rates Improve When Written Consent Is No Longer Required?
HIV/AIDS Clinical Care Summary and Comment
Free
In the San Francisco healthcare system, HIV testing rates increased significantly after the requirement for written informed consent was eliminated.
By Rochelle P. Walensky, MD, MPH
March 26, 2007
Covering:
Zetola NM et al., JAMA 2007 Mar 14; 297:1061-2
Dual Infection with HBV and HCV in HIV-Positive Patients
In HIV-infected patients who are also infected with HBV and HCV, treatment for one type of viral hepatitis does not appear to cause rebound of the other.
By Rajesh T. Gandhi, MD
March 26, 2007
Covering:
Soriano V et al., J Infect Dis 2007 Apr 15; 195:1181-3
Osteonecrosis in HIV Infection
Infectious Diseases Summary and Comment
Free
Risk for developing osteonecrosis of the hip is much higher in a cohort of HIV-infected patients than in the general population.
By Neil M. Ampel, MD
March 21, 2007
Covering:
Morse CG et al., Clin Infect Dis 2007 Mar 1; 44:739-48
Spontaneous HIV Seroreversion: Real or Apparent?
HIV/AIDS Clinical Care Summary and Comment
Free
A man at risk for HIV infection had positive results on an HIV antibody test that included both EIA and Western blot; however, these results were not confirmed by antigen or viral-load testing.
By Charles B. Hicks, MD
March 19, 2007
Covering:
Coyne KM et al., Sex Transm Dis 2007 Feb 23
High Prevalence of HPV in U.S. Females
Emergency Medicine Summary and Comment
But the prevalence of dangerous types is low.
By John A. Marx, MD, FAAEM, FACEP
March 16, 2007
Covering:
Dunne EF et al., JAMA 2007 Feb 28; 297:813-9
Let the Infected Patients Identify Their Partners . . . and Treat Them, Too
Women's Health Summary and Comment
Providing concrete resources in addition to referral responsibility may improve management of patients with STIs.
By Wendy Biggs, MD
March 15, 2007
Covering:
Trelle S et al., BMJ 2007 Feb 17; 334:354-7
A POWERful New Protease Inhibitor for HIV
Infectious Diseases Summary and Comment
Darunavir (TMC114) outperformed comparator PIs in a trial of treatment-experienced HIV-infected patients.
By Rajesh T. Gandhi, MD
March 14, 2007
Covering:
Katlama C et al., AIDS 2007 Feb 19; 21:395-402
Cost-Effectiveness of Pegylated Interferon-Alfa and Ribavirin in HCV/HIV-Coinfected Patients
Infectious Diseases Summary and Comment
A computer-based model showed increased life expectancy at an acceptable cost; benefits were greatest for patients with non–genotype-1 HCV infections.
By Neil M. Ampel, MD
March 14, 2007
Covering:
Campos NG et al., Am J Med 2007 Mar; 120:272-9
Male Circumcision Reduces HIV Incidence by Half
General Medicine Summary and Comment
Two randomized trials provide further evidence of circumcision’s protective effect.
By Bruce Soloway, MD
March 13, 2007
Covering:
Bailey RC et al., Lancet 2007 Feb 24; 369:643-56
Gray RH et al., Lancet 2007 Feb 24; 369:657-66
Newell M-L and Bärnighausen T., Lancet 2007 Feb 24; 369:617-9
Survival in HIV-Infected Patients
HIV/AIDS Clinical Care Summary and Comment
Free
Survival among HIV-infected patients has improved in recent years as a result of effective antiretroviral therapy, but it is still not comparable to that of uninfected people.
By Carlos del Rio, MD
March 12, 2007
Covering:
Lohse N et al., Ann Intern Med 2007 Jan 16; 146:87-95
Trichomoniasis Increases Risk for HIV Infection in Women
This very common STI raises women’s risk for HIV infection by 50%.
By Carlos del Rio, MD
March 12, 2007
Covering:
McClelland RS et al., J Infect Dis 2007 Mar 1; 195:698-702
HPV Prevalence in U.S. Women
General Medicine Summary and Comment
Free
Overall prevalence is higher than previously estimated, but types covered by the new vaccine are relatively uncommon.
By Thomas L. Schwenk, MD
March 8, 2007
Covering:
Dunne EF et al., JAMA 2007 Feb 28; 297:813-9
Weller SC and Stanberry LR., JAMA 2007 Feb 28; 297:876-8
