STD Reinfection During the First Year Posttreatment
Infectious Diseases Summary and Comment
Despite effective treatment, patients diagnosed with an STD were at high risk for reinfection; subsequent infections were often asymptomatic.
By Stephen G. Baum, MD
November 1, 2006
Covering:
Peterman TA et al., Ann Intern Med 2006 Oct 17; 145:564-72
Does 3TC Protect Against Liver-Related Death in HIV/HBV-Coinfected Patients?
Data from a retrospective study with 4 years of follow-up suggest yes.
By Rachel Baden, MD
October 30, 2006
Covering:
Puoti M et al., Antivir Ther 2006 ; 11:567-74
One Drug or Two for Hepatitis B in HIV-Coinfected Patients?
In HIV-HBV coinfected individuals, initial treatment with tenofovir + 3TC and sequential monotherapy with tenofovir after 3TC failure produced similar viral suppression rates, at least in the intermediate term.
By Rajesh T. Gandhi, MD
October 30, 2006
Covering:
Schmutz G et al., AIDS 2006 Oct 3; 20:1951-4
APTIMA Assay Approved for HIV Testing
For the first time, the FDA has recognized a nucleic-acid test as a tool for diagnosing HIV infection.
By Rochelle P. Walensky, MD, MPH
October 30, 2006
Will Routine Screening Further Reduce HSV Infection Rates?
Knowing a partner’s HSV status might reduce the risk for transmission.
By Alain Joffe, MD, MPH, FAAP
October 25, 2006
Covering:
Xu F et al., JAMA 2006 Aug 23; 296:964-73
Wald A et al., J Infect Dis 2006 Jul 1; 194:42-52
Hook EW and Leone P., J Infect Dis 2006 Jul 1; 194:6-7
A New Drug Target in Chlamydia trachomatis
Infectious Diseases Summary and Comment
A small molecule that inhibits bacterial type III secretion systems limits the growth of this intracellular pathogen.
By Richard T. Ellison III, MD
October 25, 2006
Covering:
Muschiol S et al., Proc Natl Acad Sci U S A 2006 Sep 26; 103:14566-71
CD4-Cell Decline Not Predicted by Viral Load
HIV/AIDS Clinical Care Summary and Comment
Free
In untreated patients, baseline plasma viral load accounted for only 4% to 6% of CD4-cell loss.
By Keith Henry, MD
October 23, 2006
Covering:
Rodríguez B et al., JAMA 2006 Sep 27; 296:1498-506
New Strategy Tried in HIV Patients with Neurosyphilis
Researchers in France had success with an aggressive approach of routine lumbar puncture and ceftriaxone therapy, but evidence is insufficient to support this strategy in routine practice.
By Charles B. Hicks, MD
October 23, 2006
Covering:
Walter T et al., Clin Infect Dis 2006 Sep 15; 43:787-90
Vulvar Ulcers: What’s Really Up down There When It’s Not an STI?
Most are consistent with aphthosis.
By M. Susan Jay, MD
October 18, 2006
Covering:
Huppert JS et al., J Pediatr Adolesc Gynecol 2006 Jun; 19:195-204
Lopinavir Levels Are Low During Late Pregnancy
Infectious Diseases Summary and Comment
HIV-infected women on lopinavir/ritonavir have low levels of lopinavir during late pregnancy, raising the question of whether dosage should be increased.
By Rajesh T. Gandhi, MD
October 18, 2006
Covering:
Stek AM et al., AIDS 2006 Oct 3; 20:1931-9
DHHS Treatment Guidelines Updated: October 2006
HIV/AIDS Clinical Care Clinical Practice Guideline Watch
Free
The revision includes substantial changes for treatment of antiretroviral-naive patients.
By Paul E. Sax, MD
October 16, 2006
Covering:
DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents -- A working group of the Office of AIDS Research Advisory Council (OARAC).,
Recent Trends in the Seroprevalence of HSV
Women's Health Summary and Comment
Data suggest a slight decrease in HSV-1 and HSV-2 infection.
By Anna Wald, MD, MPH
October 12, 2006
Covering:
Xu F et al., JAMA 2006 Aug 23; 296:964-73
Molecular Mechanism Identified for Exhausted T Cells in HIV Patients
Infectious Diseases Summary and Comment
PD-1 expression on CD8+ T cells impairs the ability of the host to eliminate HIV.
By Bradley E. Britigan, MD
October 11, 2006
Covering:
Day CL et al., Nature 2006 Sep 21; 443:350-4
Trautmann L et al., Nat Med 2006 Aug 20
CDC Recommends Universal, Routine HIV Screening for Adults
HIV/AIDS Clinical Care Clinical Practice Guideline Watch
Free
Revised recommendations call for integration of HIV testing into routine medical care.
By Carlos del Rio, MD
October 6, 2006
Covering:
Branson BM et al., MMWR Recomm Rep 2006 Sep 22; 55:1-17
Predicting CD4-Cell Decline in HIV-Infected Patients
Infectious Diseases Summary and Comment
HIV RNA levels appear to predict only a small amount of the observed variability in CD4-cell loss in individual patients with chronic untreated HIV infection.
By Rajesh T. Gandhi, MD
October 4, 2006
Covering:
Rodríguez B et al., JAMA 2006 Sep 27; 296:1498-506
Henry WK et al., JAMA 2006 Sep 27; 296:1523-5
Mortality and Its Causes in the Era of Potent Combination Antiretroviral Therapy
HIV/AIDS Clinical Care Summary and Comment
Free
Mortality rates have decreased, and the causes of death have changed.
By Carlos del Rio, MD
October 2, 2006
Covering:
Palella FJ Jr et al., J Acquir Immune Defic Syndr 2006 Sep; 43:27-34
Causes of Death Among AIDS Patients in New York City, 1999–2004
More than one fourth of AIDS patients in NYC now die from non–HIV-related causes.
By Carlos del Rio, MD
October 2, 2006
Covering:
Sackoff JE et al., Ann Intern Med 2006 Sep 19; 145:397-406
Aberg JA., Ann Intern Med 2006 Sep 19; 145:463-5
No Difference Between Three- and Four-Drug Regimens Against HIV
Emergency Medicine Summary and Comment
Results support existing standard of care.
By John A. Marx, MD, FAAEM, FACEP
September 29, 2006
Covering:
Gulick RM et al., JAMA 2006 Aug 16; 296:769-81
CDC Publishes New STD Guidelines
Women's Health Practice Watch
Free
Updates include new diagnostic considerations and treatment options.
By Diane E. Judge, APN/CNP
September 28, 2006
Covering:
MMWR Recomm Rep 2006 Aug 4; 55:1-94
HIV Integrase, a New Target for ART
Infectious Diseases Summary and Comment
New HIV integrase inhibitors look promising and may move into the clinic soon.
By Rajesh T. Gandhi, MD
September 27, 2006
Covering:
DeJesus E et al., J Acquir Immune Defic Syndr 2006 Sep; 43:1-5
HIV-Related Risk Behaviors in U.S. High School Students
CDC survey data show declines in the prevalence of several HIV-related risk behaviors, but there was little progress among Hispanic youth.
By G. Sonia Nagy, MD
September 25, 2006
Covering:
Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2006 Aug 11; 55:851-4
Evidence of a Decline in the Prevalence of HSV-1 and -2 in the U.S.
Dermatology Summary and Comment
Rates of HSV-2 seropositivity were down in the latest iteration of a large, nationwide health survey.
By Craig A. Elmets, MD
September 22, 2006
Covering:
Xu F et al., JAMA 2006 Aug 23/30; 296:964-73
Prevalence of HPV Genotypes in Women with HIV Infection
Women's Health Summary and Comment
Uncommon HPV genotypes associated with abnormal cervical cytology predominate in HIV-infected women.
By Anna Wald, MD, MPH
September 21, 2006
Covering:
Luque AE et al., J Infect Dis 2006 Aug 15; 194:428-34
A Mixed Report Card on Adolescent Health
The CDC’s Youth Risk Behavior Surveillance System tracks the health of the nation’s adolescents.
By Alain Joffe, MD, MPH, FAAP
September 20, 2006
Covering:
Eaton DK et al., MMWR Surveill Summ 2006 Jun 9; 55:1-108
Prevalence of Herpes Simplex Decreasing in the U.S.
Infectious Diseases Summary and Comment
Free
Comparison of national seroprevalence estimates for 1988–1994 and 1999–2004 showed a decreasing prevalence of both HSV-1 and HSV-2 during the 1990s.
By Richard T. Ellison III, MD
September 20, 2006
Covering:
Xu F et al., JAMA 2006 Aug 23/30; 296:964-73
