A POWERful New Protease Inhibitor for HIV
Infectious Diseases Summary and Comment
Darunavir (TMC114) outperformed comparator PIs in a trial of treatment-experienced HIV-infected patients.
By Rajesh T. Gandhi, MD
March 14, 2007
Covering:
Katlama C et al., AIDS 2007 Feb 19; 21:395-402
Cost-Effectiveness of Pegylated Interferon-Alfa and Ribavirin in HCV/HIV-Coinfected Patients
Infectious Diseases Summary and Comment
A computer-based model showed increased life expectancy at an acceptable cost; benefits were greatest for patients with non–genotype-1 HCV infections.
By Neil M. Ampel, MD
March 14, 2007
Covering:
Campos NG et al., Am J Med 2007 Mar; 120:272-9
Male Circumcision Reduces HIV Incidence by Half
General Medicine Summary and Comment
Two randomized trials provide further evidence of circumcision’s protective effect.
By Bruce Soloway, MD
March 13, 2007
Covering:
Bailey RC et al., Lancet 2007 Feb 24; 369:643-56
Gray RH et al., Lancet 2007 Feb 24; 369:657-66
Newell M-L and Bärnighausen T., Lancet 2007 Feb 24; 369:617-9
Survival in HIV-Infected Patients
HIV/AIDS Clinical Care Summary and Comment
Free
Survival among HIV-infected patients has improved in recent years as a result of effective antiretroviral therapy, but it is still not comparable to that of uninfected people.
By Carlos del Rio, MD
March 12, 2007
Covering:
Lohse N et al., Ann Intern Med 2007 Jan 16; 146:87-95
Trichomoniasis Increases Risk for HIV Infection in Women
This very common STI raises women’s risk for HIV infection by 50%.
By Carlos del Rio, MD
March 12, 2007
Covering:
McClelland RS et al., J Infect Dis 2007 Mar 1; 195:698-702
HPV Prevalence in U.S. Women
General Medicine Summary and Comment
Free
Overall prevalence is higher than previously estimated, but types covered by the new vaccine are relatively uncommon.
By Thomas L. Schwenk, MD
March 8, 2007
Covering:
Dunne EF et al., JAMA 2007 Feb 28; 297:813-9
Weller SC and Stanberry LR., JAMA 2007 Feb 28; 297:876-8
HIV Transmission During Early Infection
Infectious Diseases Summary and Comment
Free
Nearly half of HIV transmission occurs less than 6 months after seroconversion.
By Daniel J. Diekema, MD, MS
March 7, 2007
Covering:
Brenner BG et al., J Infect Dis 2007 Apr 1; 195:951-9
Pillay D and Fisher M., J Infect Dis 2007 Apr 1; 195:924-6
Postexposure Prophylaxis for HIV in Adolescents
Among 33 adolescents who received prophylactic antiretroviral therapy after sexual assault, only 9 completed the full course of treatment.
By Raphael J. Landovitz, MD
March 5, 2007
Covering:
Neu N et al., Sex Transm Dis 2007 Feb; 34:65-8
Circumcision Reduces Risk for HIV Infection
Infectious Diseases Summary and Comment
Free
Two large randomized trials in Africa showed that male circumcision reduces the risk for HIV infection by more than 50%.
By Mary E. Wilson, MD
February 28, 2007
Covering:
Bailey RC et al., Lancet 2007 Feb 24; 369:643-56
Gray RH et al., Lancet 2007 Feb 24; 369:657-66
Newell ML and Bärnighausen T., Lancet 2007 Feb 24; 369:617-9
A Tale of Two Viruses: HSV-2 and HIV
Infectious Diseases Summary and Comment
Free
Suppression of HSV-2 reactivation with valacyclovir reduces genital and plasma HIV levels.
By Rajesh T. Gandhi, MD
February 21, 2007
Covering:
Nagot N et al., N Engl J Med 2007 Feb 22; 356:790-9
Cocaine Injection, Needle Exchange, and HIV Infection
Infectious Diseases Summary and Comment
The increased risk for HIV seroconversion associated with daily participation in Vancouver’s needle-exchange program can be partially explained by daily cocaine injection.
By Neil M. Ampel, MD
February 21, 2007
Covering:
Wood E et al., Am J Med 2007 Feb; 120:172-9
High Prevalence of HSV Infection Among Pregnant Women in the U.S.
General Medicine Summary and Comment
Race/ethnicity and number of sex partners are the best predictors of HSV serostatus.
By Robert W. Rebar, MD
February 15, 2007
Covering:
Xu F et al., Am J Obstet Gynecol 2007 Jan; 196:43.e1-6
More Emergency Contraception Doesn’t Mean More Sex
Easy access to emergency contraceptive pills didn’t increase sexual risk behavior.
By Alain Joffe, MD, MPH, FAAP
February 14, 2007
Covering:
Raymond EG et al., Obstet Gynecol 2006 Nov; 108:1098-106
Preventing TB in HIV-Infected Children
Infectious Diseases Summary and Comment
Isoniazid prophylaxis in very young HIV-infected children markedly decreased TB incidence and mortality.
By Stephen G. Baum, MD
February 14, 2007
Covering:
Zar HJ et al., BMJ 2007 Jan 20; 334:136-9
Nucleoside-Sparing Regimens: The Switch Is Not Yet On
Infectious Diseases Summary and Comment
In HIV-infected patients on successful therapy, switching to a nucleoside-sparing regimen led to higher treatment-failure rates than did switching to two nucleosides plus efavirenz.
By Rajesh T. Gandhi, MD
February 14, 2007
Covering:
Fischl MA et al., AIDS 2007 Jan 30; 21:325-33
Shigellosis as a Sexually Transmitted Disease
Infectious Diseases Summary and Comment
In a case-control study, MSM, HIV infection, and direct oral-anal contact were all significantly associated with the development of shigellosis.
By Neil M. Ampel, MD
February 14, 2007
Covering:
Aragón TJ et al., Clin Infect Dis 2007 Feb 1; 44:327-34
Daskalakis DC and Blaser MJ., Clin Infect Dis 2007 Feb 1; 44:335-7
Anti-HIV Microbicide Trials Halted
Preliminary results indicate that the risk for HIV infection is higher among women using cellulose sulfate than among those using placebo.
By ACC Editors
February 12, 2007
Covering:
Treating Acute HCV in HIV-Coinfected Patients
In a small trial, more than 60% of patients achieved a sustained virologic response when HCV infection was treated during the acute phase.
By Carlos del Rio, MD
February 12, 2007
Covering:
Vogel M et al., Antivir Ther 2006 ; 11:1097-101
Syphilis Resurges in China
Infectious Diseases Summary and Comment
The incidence of syphilis in China increased 38-fold between 1993 and 1999, with the greatest increase seen in congenital syphilis.
By Mary E. Wilson, MD
February 7, 2007
Covering:
Chen ZQ et al., Lancet 2007 Jan 13; 369:132-8
Fisman DN., Lancet 2007 Jan 13; 369:84-5
Sure Enough, Couples Usually Share Trichomonas
General Medicine Summary and Comment
PCR found infection in 72% of male sexual partners of infected women; most men were asymptomatic.
By Abigail Zuger, MD
February 1, 2007
Covering:
Seña AC et al., Clin Infect Dis 2007 Jan 1; 44:13-22
Van Der Pol B., Clin Infect Dis 2007 Jan 1; 44:23-5
Liver Disease in HIV-Infected Patients
Infectious Diseases Summary and Comment
Nodular regenerative hyperplasia is a newly recognized cause of chronic liver disease in HIV-infected patients.
By Rajesh T. Gandhi, MD
January 31, 2007
Covering:
Mallet V et al., AIDS 2007 Jan 11; 21:187-92
Risk Behaviors in MSM Who Find Sex Partners on the Internet
Among recently infected MSM, those who found sex partners via the Internet reported more high-risk sexual behavior than did those who found partners through other venues.
By John JW Fangman, MD
January 29, 2007
Covering:
Smith DM et al., J Acquir Immune Defic Syndr 2006 Dec 15; 43:582-7
Social Factors Shape Young People’s Sexual Behavior Worldwide
Social expectations have a powerful influence.
By M. Susan Jay, MD
January 24, 2007
Covering:
Marston C and King E., Lancet 2006 Nov 4; 368:1581-6
Effect of Degrading Sexual Music Lyrics on Teen Sexual Behavior
Not necessarily "in one ear and out the other"
By M. Susan Jay, MD
January 10, 2007
Covering:
Martino SC et al., Pediatrics 2006 Aug; 118:e430-41
Consequences of Single-Dose Nevirapine
Infectious Diseases Summary and Comment
Free
Peripartum single-dose nevirapine reduces virologic response to subsequent nevirapine-based antiretroviral therapy in women and infants.
By Rajesh T. Gandhi, MD
January 10, 2007
Covering:
Lockman S et al., N Engl J Med 2007 Jan 11; 356:135-47
