Prevalence and Incidence of HBV Infection in an HIV-Positive Cohort
Hepatitis B virus infection continues to be a major problem in a U.S. military cohort of HIV-infected individuals. More effective "prevention for positives" is needed.
By Helmut Albrecht, MD
January 25, 2010
Covering:
Chun HM et al., Clin Infect Dis 2010 Feb 1; 50:426
No Benefit for Directly Observed Antiretroviral Therapy
General Medicine Summary and Comment
In a meta-analysis, viral suppression was similar in observed and nonobserved patients.
By Bruce Soloway, MD
January 21, 2010
Covering:
Ford N et al., Lancet 2009 Dec 19/26; 374:2064
Myers JE and Tsiouris SJ., Lancet 2009 Dec 19/26; 374:2030
HIV/HSV-2 Coinfection: Disappointing Results for Acyclovir Suppression
Infectious Diseases Summary and Comment
Free
HSV-2 suppression with acyclovir did not reduce the risk for HIV transmission.
Briefly Noted
Neonatal cutis laxa, dyskeratosis congenita, and recurrent erythema multiforme
Long-Term Efficacy of Bivalent HPV Vaccine
Women's Health Summary and Comment
Vaccine against HPV-16/18 remained highly effective for more than 6 years after administration.
By Anna Wald, MD, MPH
January 14, 2010
Covering:
Romanowski B et al., Lancet 2009 Dec 12; 374:1975
Improved Detection of Acute HIV Infection in New York City
Of the HIV diagnoses made at four city clinics, 9% were acute infections detected through pooled nucleic-acid testing among HIV antibody–negative persons.
By Anna K. Person, MD, and Charles B. Hicks, MD
January 11, 2010
Covering:
Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2009 Nov 27; 58:1296
HPV Vaccination and Pregnancy Outcomes
Women's Health Summary and Comment
Administration of the quadrivalent HPV vaccine was not associated with excess risk for adverse outcomes.
By Anna Wald, MD, MPH
January 7, 2010
Covering:
Dana A et al., Obstet Gynecol 2009 Dec; 114:1170
Garland SM et al., Obstet Gynecol 2009 Dec; 114:1179
Smith-McCune K and Sawaya GF., Obstet Gynecol 2009 Dec; 114:1168
STIs in Adolescents
The estimated prevalence of STIs in adolescent girls ranged from 14% at age 14–15 to 34% at age 18–19.
By Howard Bauchner, MD
January 6, 2010
Covering:
Forhan SE et al., Pediatrics 2009 Dec; 124:1505
HPV Vaccine Remains Highly Protective for as Long as 6.4 Years
General Medicine Summary and Comment
Growing confidence in the vaccine should lead to worldwide immunization programs.
By Bruce Soloway, MD
January 5, 2010
Covering:
Romanowski B et al., Lancet 2009 Dec 12; 374:1975
Clifford GM., Lancet 2009 Dec 12; 374:1948
Year in Review 2009: HIV/AIDS Clinical Care
HIV/AIDS Clinical Care Letter to Readers
Free
Our physician-editors offer their perspective on the year's most important stories in HIV medicine.
The Ongoing Search for New Prevention Technologies
Results became available this year from three major vaccine and microbicide trials.
HIV Treatment as Prevention
The jury's still out, but current data seem to support the theory that ART use reduces the likelihood of HIV transmission.
Top HIV/AIDS Stories of 2009
HIV/AIDS Clinical Care Letter to Readers
Free
The editors' and readers' top 10 stories from the past year
HIV Outcomes in the Clinic: Now as Good as in Clinical Trials
HIV/AIDS Clinical Care Summary and Comment
Free
Nearly 90% of HIV-infected patients receiving treatment in British Columbia are virologically suppressed.
By Paul E. Sax, MD
December 21, 2009
Covering:
Gill VS et al., Clin Infect Dis 2010 Jan 1; 50:98
Undiagnosed HIV Infection: What We Don't Know Can Hurt Us
Infectious Diseases Summary and Comment
The percentage of HIV infections in the U.S. that are undiagnosed is particularly high among blacks, high-risk heterosexual men, and young people.
By Rajesh T. Gandhi, MD
December 16, 2009
Covering:
Campsmith ML et al., J Acquir Immune Defic Syndr 2009 Oct 15
Updated DHHS Guidelines on HIV Treatment
HIV/AIDS Clinical Care Clinical Practice Guideline Watch
Free
The new guidelines recommend that lifelong ART be provided to asymptomatic HIV-infected patients with CD4 counts 3 . They also detail the specific components of "preferred" regimens.
By Abigail Zuger, MD
December 7, 2009
Covering:
Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents.,
WHO Updates HIV Treatment Recommendations
HIV/AIDS Clinical Care Clinical Practice Guideline Watch
Free
New WHO recommendations endorse earlier ART initiation for HIV-infected adolescents and adults and an even more-aggressive approach for those coinfected with TB or HBV.
By Salim S. Abdool Karim, MD, PhD
December 7, 2009
Covering:
World Health Organization.,
World Health Organization.,
World Health Organization.,
HIV Controllers and Long-Term Nonprogressors
Infectious Diseases Summary and Comment
HIV controllers and long-term nonprogressors represent overlapping but distinct groups.
By Rajesh T. Gandhi, MD
November 25, 2009
Covering:
Okulicz JF et al., J Infect Dis 2009 Dec 1; 200:1714
Hunt PW., J Infect Dis 2009 Dec 1; 200:1636
Seronegative HIV Infection
HIV/AIDS Clinical Care Summary and Comment
Free
A case report serves as a reminder that such infection does occur, sometimes with fatal consequences.
Another Flawed HIV Vaccine Disappoints
General Medicine Summary and Comment
But this time, experts salvage a hopeful message.
By Abigail Zuger, MD
November 12, 2009
Covering:
Rerks-Ngarm S et al., N Engl J Med 2009 Oct 20
Dolin R., N Engl J Med 2009 Oct 20
Can HPV Vaccination Combat Genital Warts?
Women's Health Summary and Comment
Yes — and the benefit extends beyond vaccinated women to their male sexual partners.
By Anna Wald, MD, MPH
November 5, 2009
Covering:
Fairley CK et al., Sex Transm Infect 2009 Oct 16
Therapeutic HPV Vaccination for Preventing Progression of Vulvar Intraepithelial Neoplasia
Women's Health Summary and Comment
Free
Clinical responses were achieved in women with grade 3 VIN who were vaccinated against HPV-16 viral oncoproteins.
By Anna Wald, MD, MPH
November 4, 2009
Covering:
Kenter GG et al., N Engl J Med 2009 Nov 5; 361:1838
Finn OJ and Edwards RP., N Engl J Med 2009 Nov 5; 361:1899
Darunavir + Raltegravir + Etravirine = High Rate of Treatment Success
Ninety percent of highly treatment-experienced patients who received this combination achieved virologic suppression at week 24; results were sustained at week 48.
By Paul E. Sax, MD
November 2, 2009
Covering:
Yazdanpanah Y et al., Clin Infect Dis 2009 Nov 1; 49:1441
Life Expectancy for HIV-Infected Patients in the U.S.
Average life expectancy continues to improve, but disparities persist.
A Glimmer of Hope for HIV Vaccines
HIV/AIDS Clinical Care Summary and Comment
Free
A large trial has shown that a vaccine can protect against HIV acquisition. The task now is to figure out how to build on this initial success.
By Frances H. Priddy, MD, MPH, and Carlos del Rio, MD
October 22, 2009
Covering:
Rerks-Ngarm S et al., N Engl J Med 2009 Oct 20
Dolin R., N Engl J Med 2009 Oct 20
