Photoprotection: A Review
Dermatology Summary and Comment
What we know so far about protecting skin from the harmful effects of solar radiation
By Craig A. Elmets, MD
May 18, 2007
Covering:
Lautenschlager S et al., Lancet 2007 May 3
A New WHO-EORTC System for Classifying Primary Cutaneous B-Cell Lymphomas
Dermatology Summary and Comment
Free
Reclassification using a new system yielded some changes in diagnosis.
By Angelica Selim, MD
May 4, 2007
Covering:
Senff NJ et al., J Clin Oncol 2007 Apr 20; 25:1581-7
The Lethal Thin Melanoma — Wolf in Sheep’s Clothing
Dermatology Summary and Comment
Free
A new decision tree adds previously unavailable parameters to the prediction of risk in thin melanomas.
By Hensin Tsao, MD, PhD
April 20, 2007
Covering:
Gimotty PA et al., J Clin Oncol 2007 Mar 20; 25:1129-34
Oxidative Stress and Intense Pulsed Light Therapy
Dermatology Summary and Comment
Free
Molecular study suggests that we keep an open mind about the long-term safety of IPL therapy.
By Craig A. Elmets, MD
April 13, 2007
Covering:
Sorg O et al., Arch Dermatol 2007 Mar; 143:363-6
How Much Sunscreen Is Enough?
Dermatology Summary and Comment
Real-world practice differs from laboratory conditions when it comes to applying sunscreens.
By Craig A. Elmets, MD
April 13, 2007
Covering:
Faurschou A and Wulf HC., Br J Dermatol 2007 Apr; 156:716-9
Keeping a Blue Eye on OCA2
Dermatology Summary and Comment
Variation in eye color is highly associated with three SNPs, and a connection to skin cancer risk is likely.
By Hensin Tsao, MD, PhD
March 16, 2007
Covering:
Duffy DL et al., Am J Hum Genet 2007 Feb; 80:241-52
Patching Up Squamous Cell Carcinomas
Dermatology Summary and Comment
Researchers identify a single polymorphism in a mouse gene that profoundly affects the risk for cancer formation.
By Hensin Tsao, MD, PhD
March 9, 2007
Covering:
Wakabayashi Y et al., Nature 2007 Feb 15; 445:761-5
Dermatofibrosarcoma Protuberans: Role of Immunohistochemical and Genetic Studies
Dermatology Summary and Comment
RT-PCR and FISH can assist diagnosis in hard-to-identify tumors of congenital/pediatric DFSP.
By Angelica Selim, MD
March 9, 2007
Covering:
Szollosi Z et al., J Clin Pathol 2007 Feb; 60:190-4
Maire G et al., Arch Dermatol 2007 Feb; 143:203-10
Paraneoplastic Pemphigus Without Antibodies
Dermatology Summary and Comment
Free
Is this a case of a rose by any other name? DL Cummins and colleagues (including pemphigus authority Grant Anhalt) say "yes."
By Mark V. Dahl, MD
February 23, 2007
Covering:
Cummins DL et al., J Am Acad Dermatol 2007 Jan; 56:153-9
Mycosis Fungoides and Sézary Syndrome Patients at Risk for a Second Malignancy
Dermatology Summary and Comment
The reason remains unknown.
By Craig A. Elmets, MD
January 26, 2007
Covering:
Huang KP et al., Arch Dermatol 2007 Jan; 143:45-50
How Effective Is Sunscreen for the Prevention of Nonmelanoma Skin Cancer?
Dermatology Summary and Comment
Free
The answer varies: For SCCs, very effective; for BCCs, not so much.
By Craig A. Elmets, MD
January 12, 2007
Covering:
van der Pols JC et al., Cancer Epidemiol Biomarkers Prev 2006 Dec; 15:2546-8
In Search of Prognostic Markers in Mycosis Fungoides: Another Piece of the Puzzle
Dermatology Summary and Comment
Free
Presence of T-cell gene rearrangement is a clue to the need for aggressive treatment.
By Angelica Selim, MD
January 5, 2007
Covering:
Fraser-Andrews EA et al., Br J Dermatol 2006 Oct; 155:756-62
Long-Term Efficacy of ALA Photodynamic Therapy of AKs
Dermatology Summary and Comment
In a rare, long-term study of AK therapy, ALA-PDT produces an enduring benefit.
By Craig A. Elmets, MD
December 22, 2006
Covering:
Tschen EH et al., Br J Dermatol 2006 Dec; 155:1262-9
Technical Knockdown in Melanoma
Dermatology Summary and Comment
Free
Oblimersen sodium improved the efficacy of systemic chemotherapy in patients with advanced melanoma.
By Hensin Tsao, MD, PhD
December 8, 2006
Covering:
Bedikian AY et al., J Clin Oncol 2006 Oct 10; 24:4738-45
Organ Transplant Recipients and Skin Cancer: Role of Special Dermatology Clinics
Dermatology Summary and Comment
Patient education in special dermatology clinics for transplant recipients encouraged better compliance with photoprotection recommendations.
By Craig A. Elmets, MD
December 8, 2006
Covering:
Ismail F et al., Br J Dermatol 2006 Nov; 155:916-25
"Bottled" Tans — From Artificial to Real
Dermatology Summary and Comment
Free
Topical cAMP stimulants induce fully protective tanning.
By Hensin Tsao, MD, PhD
November 3, 2006
Covering:
D’Orazio JA et al., Nature 2006 Sep 21; 443:340-4
UVA Radiation: More Serious Than Previously Thought
Dermatology Summary and Comment
Free
Far more prevalent than UVB, UVA radiation has consequences for skin health.
By Craig A. Elmets, MD
October 13, 2006
Covering:
Mouret S et al., Proc Natl Acad Sci U S A 2006 Sep 12; 103:13765-70
The Prognosis for Sentinel Lymph Node Biopsies
Dermatology Summary and Comment
Free
From "Are we there yet?" to "Where are we now?"
By Hensin Tsao, MD, PhD
September 29, 2006
Covering:
Morton DL et al., N Engl J Med 2006 Sep 28; 355:1307-17
Balch CM and Cascinelli N., N Engl J Med 2006 Sep 28; 355:1370-1
TIL Tomorrow
Dermatology Summary and Comment
Genetic engineering has generated stable monoclonal T cells that recognize melanoma.
By Hensin Tsao, MD, PhD
September 29, 2006
Covering:
Morgan RA et al., Science 2006 Aug 31
Mycosis Fungoides: Is a Double Negative a Plus?
Dermatology Summary and Comment
An atypical clinical presentation is more likely in this rare variant of early-stage MF.
By Angelica Selim, MD
September 22, 2006
Covering:
Hodak E et al., J Am Acad Dermatol 2006 Aug; 55:276-84
WHO, UV, and DALYs
Dermatology Summary and Comment
The worldwide health effects of too much <$EMPH_O>and too little<$EMPH_C> solar ultraviolet irradiation are measured in disability-adjusted life-years.
By Lowell A. Goldsmith, MD, MPH
September 15, 2006
Covering:
Lucas R et al.,
Wear Your Hat, but Don’t Forget the Sunscreen
Dermatology Summary and Comment
Free
What do hat-wearing mannequins have to tell us about solar UV protection?
By Craig A. Elmets, MD
September 8, 2006
Covering:
Gies P et al., Photochem Photobiol 2006 May/Jun; 82:750-4
Sentinel Lymph Node Biopsy for Merkel Cell Carcinoma
Dermatology Summary and Comment
Sentinel lymph node biopsy identified nodal disease in a third of patients whose clinical exams showed local disease alone.
By George J. Hruza, MD
July 14, 2006
Covering:
Gupta SG et al., Arch Dermatol 2006 Jun; 142:685-90
Imiquimod Only Modestly Successful for Squamous Cell Carcinoma in Situ
Dermatology Summary and Comment
Modest efficacy is offset by local reactions and a long treatment course.
By George J. Hruza, MD
July 14, 2006
Covering:
Patel GK et al., J Am Acad Dermatol 2006 Jun; 54:1025-32
Cure Rates of Basal Cell Carcinomas Treated with Interferon alfa-2b
Dermatology Summary and Comment
A new approach to interferon alfa-2b injections showed benefit for treatment of BCCs but may be too expensive and troublesome.
By George J. Hruza, MD
July 14, 2006
Covering:
Tucker SB et al., J Am Acad Dermatol 2006 Jun; 54:1033-8
