Cutaneous Follicle Center Lymphoma, Diffuse Type: When Small Lesions Count
Dermatology Summary and Comment
Recognizing early, inconspicuous peripheral lesions will facilitate selection of proper treatment.
By Angelica Selim, MD
December 22, 2011
Covering:
Gulia A et al., J Am Acad Dermatol 2011 Nov; 65:991
Curettage and Cryosurgery for Superficial BCCs and SCCs
Dermatology Summary and Comment
Free
For some thin cancers of the trunk and extremities, curettage followed by cryosurgery is effective.
By Mark V. Dahl, MD
December 16, 2011
Covering:
Peikert JM., Int J Dermatol 2011 Sep; 50:1135
Do Squamous Cell Carcinomas Develop More Rapidly in Patients Treated with Etanercept?
Dermatology Summary and Comment
Watch for nonmelanoma skin cancer in patients with previous UV therapy who are receiving biologic therapy.
More Links Between Metabolism and Tumors
Dermatology Summary and Comment
Somatic mosaic <$EMPH_O>IDH1<$EMPH_C> and <$EMPH_O>IDH2<$EMPH_C> mutations are implicated in Ollier disease and Maffucci syndrome.
By Kenneth Y. Tsai, MD, PhD
December 16, 2011
Covering:
Amary MF et al., Nat Genet 2011 Dec; 43:1262
Pansuriya TC et al., Nat Genet 2011 Dec; 43:1256
Dermatopathology Workforce in the U.S.: An Overview
Dermatology Summary and Comment
Who practices dermatopathology, how happy are they, and how can we assure a continuing presence at sufficiency in academia?
By Angelica Selim, MD
December 9, 2011
Covering:
Suwattee P et al., J Am Acad Dermatol 2011 Dec; 65:1180
A Rare Variant Confers Risk for Melanoma and Renal Carcinoma
Dermatology Summary and Comment
A novel recurrent mutation in <$EMPH_O>MITF<$EMPH_C> predisposes to familial and sporadic melanoma and renal cell cancer.
By Kenneth Y. Tsai, MD, PhD
December 9, 2011
Covering:
Yokoyama S et al., Nature 2011 Nov 13
Bertolotto C et al., Nature 2011 Oct 19
Lymphomatoid Papulosis: Can We Predict Evolution?
Dermatology Summary and Comment
Free
Mixed-type LyP or T-cell receptor gene rearrangement indicated a tendency to progress to lymphoma.
By Angelica Selim, MD
December 2, 2011
Covering:
de Souza A et al., J Am Acad Dermatol 2011 Oct 7
TP53 and Basal Cell Carcinomas
Dermatology Summary and Comment
Researchers identified a variant that confers susceptibility to BCCs and other cancers.
Light-Activated Nanosutures: Wound Healing for the 21st Century
Dermatology Summary and Comment
Free
Molecular protein-to-protein cross-links were formed between tissue surfaces with a combination of laser and photosensitizing dye.
Stem Cells Come to Squamous Cell Carcinoma
Dermatology Summary and Comment
Disrupting vascular endothelial growth factor signaling in mice lowered the number and survival of cancer stem cells responsible for squamous cell carcinoma.
Malignant Neurocristic Hamartoma: A Pitfall for Melanoma and Malignant Blue Nevus
Dermatology Summary and Comment
The lack of cancer gene mutations supports the notion that malignant NCH is a distinct entity from conventional and other dermal melanomas.
By Angelica Selim, MD
November 10, 2011
Covering:
Linskey KR et al., Am J Surg Pathol 2011 Oct; 35:1570.
Ultraviolet Radiation Emitted by Tanning Beds Causes DNA Mutations
Dermatology Summary and Comment
Free
UVA1 wavelengths, like UVB wavelengths, induce carcinogenic skin damage.
By Craig A. Elmets, MD
November 4, 2011
Covering:
Tewari A et al., J Invest Dermatol 2011 Oct 6
Marginal Return: Safe and Sufficient Margins for Thick Melanoma
Dermatology Summary and Comment
A 2-cm resection margin is sufficient for melanomas thicker than 2 mm.
By Hensin Tsao, MD, PhD
November 4, 2011
Covering:
Gillgren P et al., Lancet 2011 Oct 24
Thompson JF and Ollila DW., Lancet 2011 Oct 24
Guidelines for the Management of Primary Cutaneous Melanoma
Dermatology Summary and Comment
Free
AAD recommendations on treatment of primary cutaneous melanoma and evaluation of evidence of regional disease.
By Hensin Tsao, MD, PhD
October 28, 2011
Covering:
Bichakjian CK et al., J Am Acad Dermatol 2011 Nov; 65:1032
Less Is More — Number Needed to Excise Decreased as Accurate Melanoma Diagnosis Increased
Dermatology Summary and Comment
Accuracy improved during a 10-year period in specialized clinics in 13 countries.
By Hensin Tsao, MD, PhD
October 21, 2011
Covering:
Argenziano G et al., J Am Acad Dermatol 2011 Oct 6
Risk for Nonmelanoma Skin Cancer Appears Higher in Tumor Necrosis Factor Antagonist Recipients
Dermatologists can help rheumatologists recognize problematic lesions.
Neonatal Phototherapy Increases Development of Pigmented Nevi
Dermatology Summary and Comment
Safer protocols and better eye shielding are needed for this relatively easy intervention for the common problem of jaundice.
By Mary Wu Chang, MD
October 14, 2011
Covering:
Csoma Z et al., Pediatrics 2011 Oct; 128:e856
Another Look at PCSM-TCL
Dermatology Summary and Comment
A small case series shows occurrence in children and supports its classification as a low-grade lymphoma.
By Angelica Selim, MD
October 7, 2011
Covering:
Baum CL et al., J Am Acad Dermatol 2011 Oct; 65:739
More Counting . . . Now with MITF
Dermatology Summary and Comment
This clean and easy stain is the best clinical tool for determining melanocyte density.
By Angelica Selim, MD
September 23, 2011
Covering:
Black WH et al., Am J Dermatopathol 2011 Aug; 33:573
Head and Neck Squamous Cell Carcinoma Sequenced
Dermatology Summary and Comment
<$EMPH_O>TP63<$EMPH_C> and <$EMPH_O>NOTCH<$EMPH_C> mutations are involved in HNSCC, indicating that disruption of skin differentiation contributes to this cancer.
By Kenneth Y. Tsai, MD, PhD
September 23, 2011
Covering:
Agrawal N et al., Science 2011 Aug 26; 333:1154
Stransky N et al., Science 2011 Aug 26; 333:1157
Malpractice Risk in Ambulatory Settings: Substantial Risk for Dermatologists
Dermatology Summary and Comment
Three new studies quantitate risk for litigation and identify factors associated with claims and indemnity payments.
By Arthur J. Sober, MD
September 9, 2011
Covering:
Moshell AN et al., J Am Acad Dermatol 2011 Jul 15
Bishop TF et al., JAMA 2011 Jun 15; 305:2427
Jena AB et al., N Engl J Med 2011 Aug 18; 365:629
TNF Blockers Not Linked to Malignancy in General, but Concerns Remain About Skin Cancer
Contrary to earlier findings, tumor necrosis factor (TNF) blockers do not appear to be associated with malignancy in general, although they may pose increased risk...
Warfarin and Clopidogrel Are More Likely Than Aspirin to Cause Perioperative Bleeding
Dermatology Summary and Comment
Free
But office surgery is still safe in patients on anticoagulants and antithrombotics.
By Murad Alam, MD, MSCI
August 19, 2011
Covering:
Bordeaux JS et al., J Am Acad Dermatol 2011 Sep; 65:576
When Doing Mohs, Surgeons Can Use Safeguards to Get the Site Right
Dermatology Summary and Comment
Free
Reasonable, quick, low-cost precautions can virtually eliminate the risk for wrong-site Mohs surgery.
By Murad Alam, MD, MSCI
August 12, 2011
Covering:
Starling J III and Coldiron BM., J Am Acad Dermatol 2011 Jul 20
Chemokines: Attractive Targets in the Sunburn Reaction
Dermatology Summary and Comment
The chemokine CXCL5 is a peripheral mediator of pain induced by UVB irradiation to the skin.
