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Skin Cancer: Archives

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Items 51-75 of 372 are shown

Mouse Model of Congenital Nevi

Evidence suggests that <$EMPH_O>SOX10<$EMPH_C>, known to regulate human melanocyte development, may be involved in the initiation of congenital nevi.

Neighborly Stromal Cells Fuel the Fire: HGF and Melanoma

Stromal cells in the tumor microenvironment have a pivotal role in developing drug resistance in melanoma cells.

  • By Kenneth Y. Tsai, MD, PhD
  • July 20, 2012
  • Covering:
    • Wilson TR et al., Nature 2012 Jul 4
    • Straussman R et al., Nature 2012 Jul 4

RAS Strikes Again: Cutaneous Mosaicism in Nevus Sebaceous

These mutations may predispose individuals to the development of secondary tumors in nevus sebaceous

And the Hits Keep Coming

Dabrafenib significantly improved progression-free survival of stage IV melanoma patients.

Sowing the Field: Loss of Dermal CSL Signaling Promotes Epithelial Cancers

Appropriate targeting of dermal fibroblasts and stromal elements could be used to prevent skin cancer.

Tumor-Infiltrating Lymphocytes Predict SLN Status and Prognosis in Melanoma

Melanoma-specific survival rate increases with a higher TIL grade.

NSAIDs Protect Against Skin Cancer

Compared with never-users, ever-users had reduced risk for SCCs, malignant melanomas, and certain BCCs.

PDT for Basal Cell Carcinoma: A Long-Term Follow-Up

Long-term results show 5-aminolevulinic acid photodynamic therapy to be beneficial for basal cell carcinomas when surgery is not a good option.

  • By Craig A. Elmets, MD
  • June 15, 2012
  • Covering:
    • Christensen E et al., Br J Dermatol 2012 Jun; 166:1342

Down the Pathway with a MEK Inhibitor

Trametinib showed a meaningful benefit for treating BRAF-mutated melanoma in a phase III trial.

Medical Management of Basal Cell Carcinoma with a Small-Molecule Hedgehog Inhibitor

Two recent studies show efficacy of vismodegib for treating locally advanced or metastatic BCCs.

  • By Craig A. Elmets, MD
  • June 6, 2012
  • Covering:
    • Sekulic A et al., N Engl J Med 2012 Jun 7; 366:2171
    • Tang JY et al., N Engl J Med 2012 Jun 7; 366:2180

Basal Cell Carcinomas of the Ear Are More Aggressive Than Those Sited Elsewhere

An aggressive phenotype was found in 57% of ear BCCs versus 38% of cheek BCCs.

  • By Murad Alam, MD, MSCI
  • May 25, 2012
  • Covering:
    • Jarell AD and Mully TW., J Am Acad Dermatol 2012 May; 66:780

PET vs. CT for Detecting MCC Metastases: Comparison with Gold Standard Evaluation Points to the Winner

PET was more sensitive than CT for detecting MCC metastases to regional nodes.

  • By Paul Nghiem, MD, PhD
  • May 18, 2012
  • Covering:
    • Colgan MB et al., J Am Acad Dermatol 2012 Apr 30

Actinic Keratoses: Imiquimod or PDT?

At 24 weeks, ALA-PDT reduced AK counts, more than imiquimod, but the imiquimod dose was low.

D2-40 Staining Can Help Predict Metastasis in Cutaneous Squamous Cell Carcinoma

An additional diagnostic and prognostic tool for predicting risk in poorly differentiated, large, and infiltrating SCCs

Nonmelanoma Skin Cancer Rates: A Worldwide Problem

Cancer registries should include squamous cell and basal cell carcinomas to make trends in these common cancers visible.

  • By Craig A. Elmets, MD
  • May 11, 2012
  • Covering:
    • Lomas A et al., Br J Dermatol 2012 May; 166:1069

Melanoma Surveillance in the Digital Age

The most frequent dermatoscopic features associated with melanoma were focal changes in pigmentation or structure.

A New Message from the USPSTF

Behavioral counseling to prevent skin cancer is effective in young, fair-skinned patients.

  • By Hensin Tsao, MD, PhD
  • May 7, 2012
  • Covering:
    • Moyer VA on behalf of the U.S. Preventive Services Task Force., Ann Intern Med 2012 May 8

Germline BAP1 Inactivation and Metastatic Ocular Melanoma

<$EMPH_O>BAP1<$EMPH_C> mutation is associated with metastatic ocular melanoma and familial cutaneous-ocular melanoma.

UVA1 Is Often A1!

After reviewing the evidence, a workshop group discusses the effectiveness, safety, and costs of UVA1 phototherapy.

  • By Mark V. Dahl, MD
  • April 27, 2012
  • Covering:
    • Kerr AC et al., Clin Exp Dermatol 2012 Apr; 37:219

Red Melanomas

Red papules and nodules should raise suspicion of melanoma, but the mortality risk is comparable with pigmented melanomas.

  • By Mark V. Dahl, MD
  • April 27, 2012
  • Covering:
    • McClain SE et al., Int J Dermatol 2012 Apr; 51:420

The Programmed Death-1 Protein Is Often Detected in Cutaneous CD4-Positive Small/Medium-Sized Pleomorphic T-cell Lymphoma

This useful finding can prevent unnecessarily aggressive treatment.

TIL'ing Immunotherapy

Although human cancers express antigens recognized by the immune system, immune responses don't always control tumor growth; tumor cells may adapt to avoid immune surveillance.

  • By Hensin Tsao, MD, PhD
  • April 20, 2012
  • Covering:
    • Taube JM et al., Sci Transl Med 2012 Mar 28; 4:127ra37

Dermatofibrosarcoma Protuberans: Location and Transformation

Location on the extremities and fibrosarcomatous transformation indicated an increased risk for recurrence.

Surgical Margins for Melanoma in Situ

Using Mohs surgery to delineate the true dimensions of a tumor, researchers identify a better standard for excision.

  • By Murad Alam, MD, MSCI
  • April 6, 2012
  • Covering:
    • Kunishige JH et al., J Am Acad Dermatol 2012 Mar; 66:438

Can Bad Medical News Be Fatal?

Patients receiving a cancer diagnosis, especially one with poor prognosis, are at high risk for suicide or for cardiovascular death in the week following the diagnosis, and even up to a year later.

  • By Peter Roy-Byrne, MD
  • April 4, 2012
  • Covering:
    • Fang F et al., N Engl J Med 2012 Apr 5; 366:1310
Items 51-75 of 372 are shown

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