Long-Term Topical Tretinoin and Excess Mortality in Older Patients
Dermatology Summary and Comment
Free
Topical tretinoin therapy was associated with increased mortality, but current evidence suggests a causal association is unlikely.
By Craig A. Elmets, MD
January 30, 2009
Covering:
Weinstock MA et al., Arch Dermatol 2009 Jan; 145:18
Schilling LM and Dellavalle RP., Arch Dermatol 2009 Jan; 145:76
Superficial Acral Fibromyxoma: Two Retrospective Reviews
Dermatology Summary and Comment
These little-known tumors should be considered in middle-aged patients with solitary tumors located near the nails.
By Angelica Selim, MD
January 30, 2009
Covering:
Al-Daraji WI and Miettinen M., J Cutan Pathol 2008 Nov; 35:1020
Prescott RJ et al., Br J Dermatol 2008 Dec; 159:1315
Keeping an Eye on Ocular Melanoma
Dermatology Summary and Comment
An alternative route to activation of the MAP kinase pathway is identified, which suggests we need a different approach to some tumors.
ALK for Diagnosing ALCL: A Case with a Cautionary Note
Dermatology Summary and Comment
A subset of cutaneous anaplastic large cell lymphomas is positive for anaplastic lymphoma kinase, which complicates diagnosis.
By Angelica Selim, MD
January 16, 2009
Covering:
Kadin ME et al., Am J Surg Pathol 2008 Sep; 32:1421
CD30 Beyond Lymphoproliferative Disorders
Dermatology Summary and Comment
A finding of large CD30+ cells is not restricted to the usual suspects.
By Angelica Selim, MD
January 9, 2009
Covering:
Werner B et al., J Cutan Pathol 2008 Dec; 35:1100
Mohs vs. Surgical Excision for High-Risk BCCs
Dermatology Summary and Comment
Mohs surgery is cost-effective for recurrent BCCs; margins wider than 3 mm are recommended for surgical excision.
By George J. Hruza, MD
December 19, 2008
Covering:
Mosterd K et al., Lancet Oncol 2008 Dec; 9:1149
New Dogma in Melanoma
Dermatology Summary and Comment
In immunocompromised mice, many cancer cells had tumorigenic potential.
New Lamps, Old Issues: CFLs and Ultraviolet Radiation
Dermatology Summary and Comment
To avoid unsafe levels of UV exposure while saving energy, the right type of fluorescent bulb is essential.
By Mark V. Dahl, MD
December 5, 2008
Covering:
Khazova M and O’Hagan JB., Radiat Prot Dosimetry 2008 ; 131:521
Lichen Aureus: Clonal Dermatosis
Dermatology Summary and Comment
In this largest follow-up study of patients with lichen aureus, none had progressed to mycosis fungoides.
By Angelica Selim, MD
December 5, 2008
Covering:
Fink-Puches R et al., Arch Dermatol 2008 Sep; 144:1169
Specific Genetic Risk Factors for Basal Cell Carcinoma
Dermatology Summary and Comment
Some genetic factors were specific risks for BCC and not for cutaneous melanoma or squamous cell carcinoma.
Vitamin D and Actinic Keratoses
Dermatology Summary and Comment
Free
Individual susceptibility to development of actinic keratoses is influenced, in part, by polymorphisms in the gene that encodes for the vitamin D receptor.
By Mark V. Dahl, MD
October 24, 2008
Covering:
Carless MA et al., Br J Dermatol 2008 Sep; 159:804
Mocellin S and Nitti D., Cancer 2008 Nov; 113:2398
Premature Aging Takes the Heat with Infrared
Dermatology Summary and Comment
Free
Infrared A radiation increased levels of the collagen-degrading enzyme MMP-1 and depleted cutaneous antioxidents.
By Craig A. Elmets, MD
October 17, 2008
Covering:
Schroeder P et al., J Invest Dermatol 2008 Oct; 128:2491
End Nodes . . .
Dermatology Summary and Comment
Free
Tumor burden predicts additional involvement, perhaps preventing unnecessary complete lymph node dissections.
By Hensin Tsao, MD, PhD
October 10, 2008
Covering:
Gershenwald JE et al., J Clin Oncol 2008 Sep 10; 26:4296
Dermatology Summary and Comment
IFN-
By Angelica Selim, MD
October 10, 2008
Covering:
Wang W et al., J Invest Dermatol 2008 Aug; 128:1997
Primary Cutaneous Small/Medium CD4+ T-Cell Lymphomas: From Indolent to Deadly
Dermatology Summary and Comment
Clinicopathologic features distinguish subtypes of these tumors with different outcomes.
By Angelica Selim, MD
October 3, 2008
Covering:
Garcia-Herrera A et al., J Clin Oncol 2008 Jul 10; 26:3364
Do Moisturizers Promote the Development of Nonmelanoma Skin Cancers?
Dermatology Summary and Comment
Free
The findings have been widely reported in the press, but the evidence is not definitive, and applicability remains to be proved.
By Craig A. Elmets, MD
September 5, 2008
Covering:
Lu Y-P et al., J Invest Dermatol 2008 Aug 14
How to Predict DNA Mismatch Repair Status: Location, Location, Location
Dermatology Summary and Comment
Sebaceous neoplasms on the trunk and extremities are more likely to contain mismatch repair defects, which are associated with Muir-Torre syndrome and malignancy.
By Angelica Selim, MD
August 22, 2008
Covering:
Singh RS et al., Am J Surg Pathol 2008 Jun; 32:936
Melanonychia: A Question of Density
Dermatology Summary and Comment
Free
The most reliable histologic factor for distinguishing benign subungual pigmented lesions from melanoma was the number of melanocytes per millimeter.
By Angelica Selim, MD
August 8, 2008
Covering:
Amin B et al., Am J Surg Pathol 2008 Jun; 32:835
Shedding Light on the Rise of Melanoma in Young Women
Women's Health Summary and Comment
More time in the sun and on tanning beds could be responsible.
Vitamin D and Death
Dermatology Summary and Comment
Free
Low levels of vitamin D spell higher risk for Death.
By Mark V. Dahl, MD
August 1, 2008
Covering:
Dobnig H et al., Arch Intern Med 2008 Jun 23; 168:1340
Folliculotropic Mycosis Fungoides: A Distinct Entity
Dermatology Summary and Comment
This aggressive variant had a worse prognosis than classic MF, at least at early stages.
By Angelica Selim, MD
August 1, 2008
Covering:
Gerami P et al., Arch Dermatol 2008 Jun; 144:738
Which Squamous Cell Carcinomas Are the Bad Actors?
Dermatology Summary and Comment
Free
Tumor thickness, immunosuppression, location on the ear, and horizontal size were associated with increased risk for metastasis in cutaneous SCC.
Management of Depression in Cancer Patients
Psychiatry Summary and Comment
Nurses provided effective, and cost-effective, depression care.
Lichen Sclerosus and Borrelia burgdorferi : Are We Missing the Link?
Dermatology Summary and Comment
Focus-floating microscopy may be useful for establishing the role of <$EMPH_O>Borrelia burgdorferi<$EMPH_C> in LS.
By Angelica Selim, MD
July 11, 2008
Covering:
Eisendle K et al., Arch Dermatol 2008 May; 144:591
White KP et al., Arch Dermatol 2008 May; 144:662
A Rare Variant Dermatofibroma with Risk for Local Recurrence and Metastasis
Dermatology Summary and Comment
These deep fibrous histiocytomas can be aggressive, especially if not completely excised.
By Angelica Selim, MD
June 20, 2008
Covering:
Gleason BC and Fletcher CDM., Am J Surg Pathol 2008 Mar; 32:354
