CD30+ Lymphoproliferative Disease: The Mysterious Case of the Leg
Dermatology Summary and Comment
The prognosis is different for older patients with extensive leg disease.
Dissecting BCC Risk
Dermatology Summary and Comment
Free
Some genetic components of the risk for basal cell carcinoma have nothing to do with pigmentation.
Photodynamic Therapy and the Immune System
Dermatology Summary and Comment
PDT apparently increases antitumor immunity in addition to directly destroying lesions of basal cell carcinoma.
By Craig A. Elmets, MD
August 14, 2009
Covering:
Kabingu E et al., Clin Cancer Res 2009 Jul 1; 15:4460
Tanning Beds Are Human Carcinogens: Report from the WHO International Agency for Research on Cancer
Dermatology News in Context
Free
Tanning beds cause skin and eye cancer.
PPAR for the Melanoma Course
Dermatology Summary and Comment
Glitazones represent a new direction for developing molecularly targeted anticancer agents.
By Mark V. Dahl, MD
July 2, 2009
Covering:
Botton T et al., J Invest Dermatol 2009 May; 129:1208
Schadendorf D., J Invest Dermatol 2009 May; 129:1061
Cutaneous Non–AIDS-Defining Cancers in HIV-Infected Individuals
Infectious Diseases Summary and Comment
Such cancers are not associated with immune status or receipt of ART.
By Larry M. Baddour, MD
July 1, 2009
Covering:
Crum-Cianflone N et al., Arch Intern Med 2009 Jun 22; 169:1130
Ingenol Mebutate for Actinic Keratoses
Dermatology Summary and Comment
Free
A short course of this plant-based agent significantly improved AK clearance.
By George J. Hruza, MD
June 26, 2009
Covering:
Anderson L et al., J Am Acad Dermatol 2009 Jun; 60:934
Melanocytes in Lymph Nodes: BRAF Is Not the Answer
Dermatology Summary and Comment
Evidence of <$EMPH_O>BRAF<$EMPH_C> mutation in sentinel node tissue is insufficient to diagnose metastasis, as this mutation also appears in benign nodal nevi.
By Angelica Selim, MD
June 5, 2009
Covering:
Taube JM et al., Am J Surg Pathol 2009 Apr; 33:568
Mice Capades
Dermatology Summary and Comment
Activating <$EMPH_O>Braf<$EMPH_C> mutation and silencing <$EMPH_O>Pten<$EMPH_C> in melanocytes provoked melanoma with metastasis in mice.
Heavy Metal in Melanoma
Dermatology Summary and Comment
Mutations that restricted the production of a matrix metalloprotein diminished tumor suppression and fostered aggressive characteristics in cancer cells.
A Potential Overcall: Recurrent Melanocytic Nevi
Dermatology Summary and Comment
These lesions resemble malignant melanomas with regression, but clinical characteristics can help to differentiate the two.
Briefly Noted
Counseling patients at risk for melanoma, factors associated with malignancy in dermatomyositis, guidelines for safe use of methotrexate for psoriasis, and a new TNF-
Vitamin D and Health
Do we have enough? How do we get more? What systems are affected?
Oncogenic Lesions in Lentigines
Dermatology Summary and Comment
Free
Researchers establish a genetic link between keratoses and lentigines, but not all mutations lead to cancer.
The Bottom Line on Acral Melanoma
Dermatology Summary and Comment
These tumors are not increasing in incidence as quickly as other melanomas, but they are associated with worse prognosis.
Mycosis Fungoides: Clusterin and Large-Cell Transformation
Dermatology Summary and Comment
The clusterin glycoprotein was found in most cases of MF with large-cell tumors.
By Angelica Selim, MD
April 17, 2009
Covering:
Chandra P et al., Am J Clin Pathol 2009 Apr; 131:511
Melanoma and Maternity
Dermatology Summary and Comment
Free
Melanoma risk is higher than usual during pregnancy and the 6 months thereafter, but women with postcancer pregnancies have good survival rates.
Encouraging Intolerance
Dermatology Summary and Comment
Blocking CTLA4 can disrupt the development of tolerance and enhance the body’s antitumor efforts, but we have not yet found the right agents.
By Hensin Tsao, MD, PhD
April 3, 2009
Covering:
Weber JS et al., J Clin Oncol 2008 Dec 20; 26:5950
Camacho LH et al., J Clin Oncol 2009 Mar 1; 27:1075
Briefly Noted
Statins’ effect on nonmelanoma skin cancer, minocycline-induced drug hypersensitivity, anti-TNF-
Caffeine as a Photoprotective Agent
Dermatology Summary and Comment
Free
Something to peruse over your morning cup of coffee
By Craig A. Elmets, MD
March 6, 2009
Covering:
Heffernan TP et al., J Invest Dermatol 2009 Feb 26
Ingenol Mebutate for Actinic Keratoses
Dermatology Summary and Comment
A plant extract traditionally used for skin disease in Australia may change our therapeutic approach to AKs.
By George J. Hruza, MD
February 27, 2009
Covering:
Siller G et al., Australas J Dermatol 2009 Feb; 50:16
USPSTF: Evidence Is Insufficient to Recommend Skin Cancer Screening
General Medicine Clinical Practice Guideline Watch
The task force recognizes clinicians’ frustration with lack of guidance by the USPSTF when evidence is insufficient.
By Richard Saitz, MD, MPH, FACP, FASAM
February 17, 2009
Covering:
Wolff T et al., Ann Intern Med 2009 Feb 3; 150:194
U.S. Preventive Services Task Force., Ann Intern Med 2009 Feb 3; 150:188
Petitti DB et al., Ann Intern Med 2009 Feb 3; 150:199
The Cross-Paramedian Forehead Flap
Dermatology Summary and Comment
Free
A modification in flap orientation produced a good repair in large nasal defects and a better donor-site scar.
By George J. Hruza, MD
February 13, 2009
Covering:
Angobaldo J and Marks M., Plast Reconstr Surg 2009 Jan; 123:87
Mycosis Fungoides with Granulomas: One Story, Two Endings
Dermatology Summary and Comment
The granulomatous mycosis fungoides subtype requires aggressive care and surveillance.
By Angelica Selim, MD
February 6, 2009
Covering:
Kempf W et al., Arch Dermatol 2008 Dec; 144:1609
Screening for Skin Cancer: The Evidence Is Still Insufficient
Dermatology Summary and Comment
Free
Randomized, controlled trials of sufficient size and scope are still needed.
By June K. Robinson, MD
February 3, 2009
Covering:
U.S. Preventive Services Task Force., Ann Intern Med 2009 Feb 3; 150:188
Wolff T et al., Ann Intern Med 2009 Feb 3; 150:194
