BRIEFLY NOTED
Myopathy-related risk for arterial disease, low ambient UV and prevalence of immune disease, questioning the link between isotretinoin and IBD, and a severe combined immunodeficiency variant
Sunscreen for Organ Transplant Recipients
Dermatology Summary and Comment
An ounce of sunscreen is worth a pound of cure.
By Craig A. Elmets, MD
October 23, 2009
Covering:
Ulrich C et al., Br J Dermatol 2009 Nov; 161:78
KIT: Immunohistochemical Detection and Genetic Analysis
Dermatology Summary and Comment
Acral lentiginous/mucosal melanomas are more likely than other types to harbor <$EMPH_O>KIT<$EMPH_C> mutations, and IHC staining can help identify higher-risk patients.
FISHing for a Diagnosis
Dermatology Summary and Comment
We are close to landing a helpful tool for distinguishing melanomas from benign nevi.
Scope This Out
Dermatology Summary and Comment
Free
About 43% of dermatologists use dermoscopy on a daily basis to aid diagnosis of lesions — and to reassure patients.
By Mark V. Dahl, MD
October 16, 2009
Covering:
Noor O 2nd et al., Int J Dermatol 2009 Sep; 48:951
Digital Anesthesia with Added Epinephrine
Dermatology Summary and Comment
Even patients with considerable comorbidities had no adverse effects from epinephrine.
By George J. Hruza, MD
October 16, 2009
Covering:
Firoz B et al., J Am Acad Dermatol 2009 Oct; 61:639
Dermatology Summary and Comment
Free
Insufficient tumor necrosis factor affected the ability of T lymphocytes to migrate to the skin.
By Craig A. Elmets, MD
October 9, 2009
Covering:
Agius E et al., J Exp Med 2009 Aug 31; 206:1929
Polymorphisms in CTLA4 Confer Susceptibility to Nonmelanoma Skin Cancers
Dermatology Summary and Comment
Free
A genetic variant that confers excess risk for autoimmune disease may also protect against nonmelanoma skin cancers.
By Craig A. Elmets, MD
September 25, 2009
Covering:
Welsh MM et al., Cancer Res 2009 Aug 1; 69:6158
Elastin: A Matter of Boundaries
Dermatology Summary and Comment
Free
An easily available tool helps to evaluate nevi-associated malignant melanoma.
A Mole Gene Among Us
Dermatology Summary and Comment
Researchers locate variants associated with elevated nevus count, a melanoma risk factor.
Not Only B but Also T: Lymphomas Localized to the Leg
Dermatology Summary and Comment
In a new variant of cutaneous T-cell lymphoma, tumor aggression is again associated with location.
It's Official: Tanning Beds Cause Cancer
The WHO International Agency for Research on Cancer has raised the classification of ultraviolet-emitting tanning devices to "carcinogenic to humans."
Trimming the Hedgehog
Dermatology Summary and Comment
Free
A novel inhibitor of the hedgehog signaling pathway had promising results in patients with metastatic and aggressive local BCCs.
By Hensin Tsao, MD, PhD
September 2, 2009
Covering:
Von Hoff DD et al., N Engl J Med 2009 Sep 2
Dlugosz AA and Talpaz M., N Engl J Med 2009 Sep 2
Nonmelanoma Skin Cancers in Patients with HIV Mirror Cancer in the General Population
Dermatology Summary and Comment
In persons with HIV infection, as in the general population, the factors most associated with the development of cutaneous malignancies are the traditional ones.
By Jeffrey P. Callen, MD
August 28, 2009
Covering:
Crum-Cianflone N et al., Arch Intern Med 2009 Jun 22; 169:1130
CD30+ Lymphoproliferative Disease: The Mysterious Case of the Leg
Dermatology Summary and Comment
The prognosis is different for older patients with extensive leg disease.
Dissecting BCC Risk
Dermatology Summary and Comment
Free
Some genetic components of the risk for basal cell carcinoma have nothing to do with pigmentation.
Photodynamic Therapy and the Immune System
Dermatology Summary and Comment
PDT apparently increases antitumor immunity in addition to directly destroying lesions of basal cell carcinoma.
By Craig A. Elmets, MD
August 14, 2009
Covering:
Kabingu E et al., Clin Cancer Res 2009 Jul 1; 15:4460
Tanning Beds Are Human Carcinogens: Report from the WHO International Agency for Research on Cancer
Dermatology News in Context
Free
Tanning beds cause skin and eye cancer.
By Craig A. Elmets, MD
July 30, 2009
Covering:
El Ghissassi F et al., Lancet Oncol 2009 Aug; 10:751
PPAR for the Melanoma Course
Dermatology Summary and Comment
Glitazones represent a new direction for developing molecularly targeted anticancer agents.
By Mark V. Dahl, MD
July 2, 2009
Covering:
Botton T et al., J Invest Dermatol 2009 May; 129:1208
Schadendorf D., J Invest Dermatol 2009 May; 129:1061
Cutaneous Non–AIDS-Defining Cancers in HIV-Infected Individuals
Infectious Diseases Summary and Comment
Such cancers are not associated with immune status or receipt of ART.
By Larry M. Baddour, MD
July 1, 2009
Covering:
Crum-Cianflone N et al., Arch Intern Med 2009 Jun 22; 169:1130
Ingenol Mebutate for Actinic Keratoses
Dermatology Summary and Comment
Free
A short course of this plant-based agent significantly improved AK clearance.
By George J. Hruza, MD
June 26, 2009
Covering:
Anderson L et al., J Am Acad Dermatol 2009 Jun; 60:934
Melanocytes in Lymph Nodes: BRAF Is Not the Answer
Dermatology Summary and Comment
Evidence of <$EMPH_O>BRAF<$EMPH_C> mutation in sentinel node tissue is insufficient to diagnose metastasis, as this mutation also appears in benign nodal nevi.
By Angelica Selim, MD
June 5, 2009
Covering:
Taube JM et al., Am J Surg Pathol 2009 Apr; 33:568
Mice Capades
Dermatology Summary and Comment
Activating <$EMPH_O>Braf<$EMPH_C> mutation and silencing <$EMPH_O>Pten<$EMPH_C> in melanocytes provoked melanoma with metastasis in mice.
Heavy Metal in Melanoma
Dermatology Summary and Comment
Mutations that restricted the production of a matrix metalloprotein diminished tumor suppression and fostered aggressive characteristics in cancer cells.
A Potential Overcall: Recurrent Melanocytic Nevi
Dermatology Summary and Comment
These lesions resemble malignant melanomas with regression, but clinical characteristics can help to differentiate the two.
