Basal Cell Carcinoma at a Young Age: Another Consequence of Tanning Beds
Dermatology Summary and Comment
Free
Tanning bed users younger than 40 developed early-onset BCCs significantly more often than nonusers.
By Craig A. Elmets, MD
February 3, 2012
Covering:
Ferrucci LM et al., J Am Acad Dermatol 2011 Dec 8
Vitamin D and Calcium Supplements: What Do the Data Show? Who Should Be Treated?
Dermatology Summary and Comment
Vitamin D and calcium supplementation may lower fracture risk in some individuals, but data regarding its effects on cancer are inconclusive.
By Craig A. Elmets, MD
January 27, 2012
Covering:
Chung M et al., Ann Intern Med 2011 Dec 20; 155:827
Adnexal Tumor: Useful Information in a Pathology Report
Dermatology Summary and Comment
Pagetoid spread and an infiltrative growth pattern suggest the need for extended excision of some eccrine porocarcinomas.
By Angelica Selim, MD
January 27, 2012
Covering:
Belin E et al., Br J Dermatol 2011 Nov; 165:985
A Proposed Mechanism Behind SCC Formation in Vemurafenib Recipients
Dermatology Summary and Comment
Free
The presence of <$EMPH_O>RAS<$EMPH_C> mutations suggests that preexisting keratinocytes bearing these mutations are unmasked by vemurafenib
Stem Cells on the Clock: Circadian Rhythm Proteins Regulate Epidermal Stem Cells
Dermatology Summary and Comment
Investigators found an association between expression of genes associated with stem cell function and expression of circadian rhythm genes.
Vitamin D and UVB Radiation: How Much Is Necessary?
Dermatology Summary and Comment
Free
For individuals unable to benefit from supplements, ultraviolet B exposure every 2 weeks may be an alternative.
More Evidence That Combined Tacrolimus and Narrowband UVB Are Useful for Vitiligo
Dermatology Summary and Comment
Free
Combined treatment was better than ultraviolet treatment alone, and the effects were tacrolimus dose-dependent.
By Craig A. Elmets, MD
January 6, 2012
Covering:
Nordal EJ et al., J Eur Acad Dermatol Venereol 2011 Dec; 25:1440
Granulomatous Processes and Clonality: PCR Evaluation of T-Cell Rearrangement for Diagnosis
Dermatology Summary and Comment
Analysis of T-cell clonality is useful for differentiating sarcoidosis and primary granuloma annulare from granulomatous CTCLs.
By Angelica Selim, MD
January 6, 2012
Covering:
Pfaltz K et al., Am J Dermatopathol 2011 Oct; 33:659
How Effective Is Melanoma Screening?
Dermatology Summary and Comment
Free
Melanoma mortality dropped significantly in one German state after a population-wide screening project, while mortality rates remained stable in the rest of Germany.
By Hensin Tsao, MD, PhD
December 22, 2011
Covering:
Breitbart EW et al., J Am Acad Dermatol 2011 Nov 8
Behind the Numbers: Number Needed to Screen
Dr. Joel Gelfand elucidates the concept of number needed to screen in "Behind the Numbers", a new <$EMPH_O>Journal Watch Dermatology<$EMPH_C> feature aimed at clarifying issues in epidemiologic design and biostatistics.
By Joel M. Gelfand, MD, MSCE
December 22, 2011
Cutaneous Follicle Center Lymphoma, Diffuse Type: When Small Lesions Count
Dermatology Summary and Comment
Recognizing early, inconspicuous peripheral lesions will facilitate selection of proper treatment.
By Angelica Selim, MD
December 22, 2011
Covering:
Gulia A et al., J Am Acad Dermatol 2011 Nov; 65:991
Curettage and Cryosurgery for Superficial BCCs and SCCs
Dermatology Summary and Comment
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For some thin cancers of the trunk and extremities, curettage followed by cryosurgery is effective.
By Mark V. Dahl, MD
December 16, 2011
Covering:
Peikert JM., Int J Dermatol 2011 Sep; 50:1135
Do Squamous Cell Carcinomas Develop More Rapidly in Patients Treated with Etanercept?
Dermatology Summary and Comment
Watch for nonmelanoma skin cancer in patients with previous UV therapy who are receiving biologic therapy.
More Links Between Metabolism and Tumors
Dermatology Summary and Comment
Somatic mosaic <$EMPH_O>IDH1<$EMPH_C> and <$EMPH_O>IDH2<$EMPH_C> mutations are implicated in Ollier disease and Maffucci syndrome.
By Kenneth Y. Tsai, MD, PhD
December 16, 2011
Covering:
Amary MF et al., Nat Genet 2011 Dec; 43:1262
Pansuriya TC et al., Nat Genet 2011 Dec; 43:1256
Dermatopathology Workforce in the U.S.: An Overview
Dermatology Summary and Comment
Who practices dermatopathology, how happy are they, and how can we assure a continuing presence at sufficiency in academia?
By Angelica Selim, MD
December 9, 2011
Covering:
Suwattee P et al., J Am Acad Dermatol 2011 Dec; 65:1180
A Rare Variant Confers Risk for Melanoma and Renal Carcinoma
Dermatology Summary and Comment
A novel recurrent mutation in <$EMPH_O>MITF<$EMPH_C> predisposes to familial and sporadic melanoma and renal cell cancer.
By Kenneth Y. Tsai, MD, PhD
December 9, 2011
Covering:
Yokoyama S et al., Nature 2011 Nov 13
Bertolotto C et al., Nature 2011 Oct 19
Lymphomatoid Papulosis: Can We Predict Evolution?
Dermatology Summary and Comment
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Mixed-type LyP or T-cell receptor gene rearrangement indicated a tendency to progress to lymphoma.
By Angelica Selim, MD
December 2, 2011
Covering:
de Souza A et al., J Am Acad Dermatol 2011 Oct 7
TP53 and Basal Cell Carcinomas
Dermatology Summary and Comment
Researchers identified a variant that confers susceptibility to BCCs and other cancers.
Light-Activated Nanosutures: Wound Healing for the 21st Century
Dermatology Summary and Comment
Free
Molecular protein-to-protein cross-links were formed between tissue surfaces with a combination of laser and photosensitizing dye.
Stem Cells Come to Squamous Cell Carcinoma
Dermatology Summary and Comment
Disrupting vascular endothelial growth factor signaling in mice lowered the number and survival of cancer stem cells responsible for squamous cell carcinoma.
Malignant Neurocristic Hamartoma: A Pitfall for Melanoma and Malignant Blue Nevus
Dermatology Summary and Comment
The lack of cancer gene mutations supports the notion that malignant NCH is a distinct entity from conventional and other dermal melanomas.
By Angelica Selim, MD
November 10, 2011
Covering:
Linskey KR et al., Am J Surg Pathol 2011 Oct; 35:1570.
Ultraviolet Radiation Emitted by Tanning Beds Causes DNA Mutations
Dermatology Summary and Comment
Free
UVA1 wavelengths, like UVB wavelengths, induce carcinogenic skin damage.
By Craig A. Elmets, MD
November 4, 2011
Covering:
Tewari A et al., J Invest Dermatol 2011 Oct 6
Marginal Return: Safe and Sufficient Margins for Thick Melanoma
Dermatology Summary and Comment
A 2-cm resection margin is sufficient for melanomas thicker than 2 mm.
By Hensin Tsao, MD, PhD
November 4, 2011
Covering:
Gillgren P et al., Lancet 2011 Oct 24
Thompson JF and Ollila DW., Lancet 2011 Oct 24
Guidelines for the Management of Primary Cutaneous Melanoma
Dermatology Summary and Comment
Free
AAD recommendations on treatment of primary cutaneous melanoma and evaluation of evidence of regional disease.
By Hensin Tsao, MD, PhD
October 28, 2011
Covering:
Bichakjian CK et al., J Am Acad Dermatol 2011 Nov; 65:1032
Less Is More — Number Needed to Excise Decreased as Accurate Melanoma Diagnosis Increased
Dermatology Summary and Comment
Accuracy improved during a 10-year period in specialized clinics in 13 countries.
By Hensin Tsao, MD, PhD
October 21, 2011
Covering:
Argenziano G et al., J Am Acad Dermatol 2011 Oct 6
