Oral Raloxifene, Transdermal Estradiol Similar at Preserving Bone Density
Women's Health Summary and Comment
Postmenopausal users of these two drugs had similarly high rates of bone density preservation and few serious side effects.
Concomitant Management of Depression and Pain
General Medicine Summary and Comment
An intensive, combined approach was more effective than usual care, but absolute response rates were still modest.
"Microdose" Transdermal Estradiol: As Effective as Raloxifene in Preventing Bone Loss?
General Medicine Summary and Comment
Even very low doses of estrogen can help prevent bone loss.
By Robert W. Rebar, MD
June 9, 2009
Covering:
Schaefers M et al., Menopause 2009 May/Jun; 16:559
Vitamin D and Health
Do we have enough? How do we get more? What systems are affected?
Bisphosphonates for Glucocorticoid Users: Yearly or Daily?
Women's Health Summary and Comment
Yearly intravenous zoledronic acid was not inferior to daily oral risedronate.
By Anna Wald, MD, MPH
May 21, 2009
Covering:
Reid DM et al., Lancet 2009 Apr 11; 373:1253
Gennari L and Bilezikian JP., Lancet 2009 Apr 11; 373:1225
The HORIZON Study: Bisphosphonates for Patients on Corticosteroids
Dermatology Summary and Comment
Free
Once-yearly infusion of a bisphosphonate may be more effective and more convenient than daily bisphosphonate for preventing and treating glucocorticortoid-induced osteroporosis.
By Jeffrey P. Callen, MD
May 1, 2009
Covering:
Reid DM et al., Lancet 2009 Apr 11; 373:1253
Gennari L and Bilezikian JP., Lancet 2009 Apr 11; 373:1225
Cheers! Drinking Alcohol Might Preserve Bone Density in Postmenopausal Women
Women's Health Summary and Comment
Greater intake of alcoholic beverages, especially wine, correlated with higher bone density.
Vitamin D Levels in Elders
General Medicine Summary and Comment
Free
Most older people had low serum levels, and at least 25% of elders had frank vitamin D deficiency.
By Allan S. Brett, MD
April 23, 2009
Covering:
Orwoll E et al., J Clin Endocrinol Metab 2009 Apr; 94:1214
Kuchuk NO et al., J Clin Endocrinol Metab 2009 Apr; 94:1244
Briefly Noted
Genetics of diversity in human pigmentation, risks for bisphosphonate-induced osteonecrosis of the jaw, and a newly approved agent for head lice
One Bad Break Leads to Another
Women's Health Summary and Comment
Risk for hip fracture was six times higher during the first year after a proximal humeral fracture.
By Wendy S. Biggs, MD
April 9, 2009
Covering:
Clinton J et al., J Bone Joint Surg Am 2009 Mar 1; 91:503
Balloon Kyphoplasty for Spinal Compression Fracture
General Medicine Summary and Comment
At 1 month, kyphoplasty patients had significantly greater improvements in global quality of life, back pain, and function than did controls.
By Bruce Soloway, MD
April 7, 2009
Covering:
Wardlaw D et al., Lancet 2009 Mar 21; 373:1016
Kallmes DF and Jarvik JG., Lancet 2009 Mar 21; 373:982
Diagnosing Diabetic Osteomyelitis: Needle Puncture vs. Bone Biopsy
Infectious Diseases Summary and Comment
Needle puncture was easier to perform but did not reliably identify bone bacteria.
By Neil M. Ampel, MD
March 25, 2009
Covering:
Senneville E et al., Clin Infect Dis 2009 Apr 1; 48:888
Osteoporosis: Another Risk for Patients with Psoriasis?
Dermatology Summary and Comment
In men, psoriasis was significantly associated with an increased risk for decreased bone-mineral density.
Vitamin D — It’s Not Just for Bones
Higher vitamin D levels correlated with better muscle power and force in adolescent girls.
Fracture Incidence Climbed After Publication of WHI Data
Women's Health Summary and Comment
From 2000 through 2005, fracture incidence rose among postmenopausal women whereas HT use fell.
Assessing Fracture Risk Might Be as Easy as Asking About Balance
Women's Health Summary and Comment
Results of a twin study support the value of self-reported balance problems for predicting fracture risk.
Imaging Does Not Alter Outcomes in Acute Low Back Pain
General Medicine Summary and Comment
A meta-analysis provides more reason to curb routine lumbar imaging.
By Bruce Soloway, MD
February 17, 2009
Covering:
Chou R et al., Lancet 2009 Feb 7; 373:463
Kochen MM et al., Lancet 2009 Feb 7; 373:436
Do Loop Diuretics Increase the Risk for Fractures in Postmenopausal Women?
Cardiology Summary and Comment
Findings from the Women’s Health Initiative suggest that they don’t, but many questions remain.
By JoAnne M. Foody, MD
February 11, 2009
Covering:
Carbone LD et al., Arch Intern Med 2009 Jan 26; 169:132
Mortality Risk Following Osteoporotic Fracture
General Medicine Summary and Comment
Free
Elevated risk was associated with even minor fractures and, with hip fractures, persisted for at least 10 years.
Rosiglitazone, Pioglitazone, and Fractures: A Meta-Analysis
General Medicine Summary and Comment
Combined data from 10 trials show that rosiglitazone and pioglitazone confer significant risk for fractures.
New Approach to Prevention of Osteoporotic Fractures
Clinical calculators can help clinicians determine when patients should start receiving osteoporosis therapy.
Falls After Age 90: Inability to Get Up and Prolonged Time on Floor Portend Poor Outcomes
General Medicine Summary and Comment
Many elders with access to alarm systems did not use them.
Calcium Supplementation in Healthy Nonosteoporotic Men
General Medicine Summary and Comment
Free
Calcium supplementation is not just for women.
A Broken Wrist Might Not Mean Fragile Bones
Women's Health Summary and Comment
Women who sustained wrist fractures had elevated risk for recurrent fractures, but the risk was less than that associated with other fragility fractures.
By Wendy S. Biggs, MD
December 11, 2008
Covering:
Hodsman AB et al., Arch Intern Med 2008 Nov 10; 168:2261
Long-Term Growth and Bone Mineralization in Preterm Children
Low bone mineralization persists up to age 9 years in children who were born preterm with low birth weight.
