How Depression Causes a Weak Leg to Stand On
Psychiatry Summary and Comment
Free
This animal study suggests that depression might be a treatable risk factor for osteoporosis.
By Jonathan Silver, MD
December 4, 2006
Covering:
Yirmiya R et al., Proc Natl Acad Sci U S A 2006 Nov 7; 103:16876-81
Depression, Borderline Personality Disorder, and Osteoporosis?
Psychiatry Summary and Comment
Risk for bone loss is especially high in younger women with major depression and borderline personality disorder.
By Joel Yager, MD
December 4, 2006
Covering:
Kahl KG et al., Psychosom Med 2006 Sep/Oct; 68:669-74
A New COX-2 Inhibitor Is No More Cardiotoxic Than an Older NSAID
General Medicine Summary and Comment
Etoricoxib had similar rates of thrombotic cardiovascular events as diclofenac, but caused more hypertension and edema.
By Bruce Soloway, MD
November 28, 2006
Covering:
Cannon CP et al., Lancet 2006 Nov 18; 368:1771-81
García Rodríguez LA and Patrignani P., Lancet 2006 Nov 18; 368:1745-7
Rituximab for Refractory RA
General Medicine Summary and Comment
A single course of this agent produced significant clinical and functional benefits, measured at 24 weeks.
By Deborah M. DeMarco, MD
November 28, 2006
Covering:
Cohen SB et al., Arthritis Rheum 2006 Sep; 54:2793-806
CV Risk with Etoricoxib vs. Diclofenac
Cardiology Summary and Comment
Cardiovascular outcomes with the traditional NSAID diclofenac and the still-unapproved selective COX-2 inhibitor etoricoxib were compared by researchers who pooled results from three non–placebo-controlled randomized trials.
By Beat J. Meyer, MD
November 22, 2006
Covering:
Cannon CP et al. for the MEDAL Steering Committee., Lancet 2006 Nov 18; 368:1771-81
García Rodríguez LA and Patrignani P., Lancet 2006 Nov 18; 368:1745-7
Adverse Events and Intravenous Immunoglobulin
Delayed adverse events occur frequently after IVIG in children.
By F. Bruder Stapleton, MD
November 15, 2006
Covering:
Singh-Grewal D et al., Arch Dis Child 2006 Aug; 91:651-4
Is Ibuprofen Helpful After Hip Replacement Surgery?
General Medicine Summary and Comment
Although ibuprofen decreased the risk for ectopic bone formation, it had no effect on long-term pain or disability in this randomized, controlled study.
By Keith I. Marton, MD
October 17, 2006
Covering:
Fransen M et al., BMJ 2006 Sep 9; 333:519-21
Chaperonin 10: Early Evidence of Efficacy in Rheumatoid Arthritis
General Medicine Summary and Comment
Free
This new therapeutic approach might offer relief for patients with treatment-resistant RA.
By Bruce Soloway, MD
October 10, 2006
Covering:
Vanags D et al., Lancet 2006 Sep 2; 368:855-63
Bisphosphonate Is Best to Prevent Corticosteroid-Induced Osteoporosis
Women's Health Summary and Comment
Free
For patients taking corticosteroids, alendronate is more effective than alfacalcidol at preserving bone mineral density.
By Andrew M. Kaunitz, MD
October 5, 2006
Covering:
de Nijs RN et al., N Engl J Med 2006 Aug 17; 355:675-84
When Are Two Genetic Hits Enough to Break a Bone?
When double hits in the <$EMPH_O>NF1<$EMPH_C> gene lead to pseudarthrosis
By Judith G. Hall, OC, MD
October 4, 2006
Covering:
Stevenson DA et al., Am J Hum Genet 2006 Jul; 79:143-8
Bisphosphonates and Osteonecrosis of the Jaw
Women's Health Practice Watch
ONJ is a rare but serious adverse event associated with bisphosphonate therapy.
By Michael R. McClung, MD, FACP, FACE
September 14, 2006
Covering:
Woo SB et al., Ann Intern Med 2006 May 16; 144:753-61
Serious Infections with Anti-TNF Drugs for RA
General Medicine Summary and Comment
Free
The overall rate of serious infections was the same with anti-TNF drugs as with traditional DMARDs, but skin and soft-tissue infections were more common.
By Allan S. Brett, MD
September 7, 2006
Covering:
Dixon WG et al., Arthritis Rheum 2006 Aug; 54:2368-76
Infliximab (Remicade)
An overview of indications, pharmacology, dosing, and side effects, with an emphasis on what we know about its use in children
By Ghassan Wahbeh, MD
September 6, 2006
Covering:
Adams AE et al., J Am Acad Dermatol 2004 Oct; 51:660-2
Bongartz T et al., JAMA 2006 May 17; 295:2275-85
Dekker L et al., Clin Exp Rheumatol 2004 Mar/Apr; 22:252-8
Hyams J et al., Digestive Disease Week 2006 Abstract #57
Ilowite NT., Pediatrics 2002 Jan; 109:109-15
Lichtenstein GR et al., Clin Gastroenterol Hepatol 2006 May; 4:621-30
Thayu M et al., J Pediatr Gastroenterol Nutr 2005 Feb; 40:220-2
Staying in the Game: Risk Factors for Arm Injuries in Adolescent Baseball Pitchers
Pitching habits differ between those with and without arm injuries.
By M. Susan Jay, MD
August 30, 2006
Covering:
Olsen SJ 2nd et al., Am J Sports Med 2006 Jun; 34:905-12
Trying to Define Osteonecrosis Risk Factors in HIV Patients
Prior AIDS-defining illness, lower CD4-cell–count nadir, and combination antiretroviral therapy were all associated with increased risk for osteonecrosis. However, nearly 90% of patients with this condition also had at least one traditional risk factor for it.
By Paul E. Sax, MD
August 28, 2006
Covering:
Mary-Krause M et al., AIDS 2006 Aug 1; 20:1627-35
New Therapy for Neonatal-Onset Multisystem Inflammatory Disease
Dermatology Summary and Comment
Free
A rare condition with prominent cutaneous features responded immediately to treatment with an interleukin-1-receptor antagonist.
By Jeffrey P. Callen, MD
August 11, 2006
Covering:
Goldbach-Mansky R et al., N Engl J Med 2006 Aug 10; 355:581-92
Osteonecrosis in HIV: Traditional Risk Factors Usually Present
In this retrospective case series, most HIV-infected patients with osteonecrosis had at least one well-recognized risk factor for the condition.
By Paul E. Sax, MD
July 31, 2006
Covering:
Gutierrez F et al., J Acquir Immune Defic Syndr 2006 Jul; 42:286-92
Acute Lymphocytic Leukemia or Juvenile Rheumatoid Arthritis?
Predictive factors at initial presentation could help distinguish ALL from JRA.
By Cornelius W. Van Niel, MD
August 2, 2006
Covering:
Jones OY et al., Pediatrics 2006 May; 117:e840-4
Is Acupuncture Effective for Knee Osteoarthritis?
General Medicine Summary and Comment
Both traditional and sham needling led to less pain and better function.
By Richard Saitz, MD, MPH, FACP, FASAM
August 1, 2006
Covering:
Scharf HP et al., Ann Intern Med 2006 Jul 4; 145:12-20
Risk for Fractures with Antiepileptic Drugs
Neurology Summary and Comment
Is the risk from only enzyme-inducing AEDs?
By Barbara Dworetzky, MD
July 18, 2006
Covering:
Souverein PC et al., Neurology 2006 May 9; 66:1318-24
Anti-TNF Antibody Therapies — How Safe?
Women's Health Summary and Comment
Treatment of rheumatoid arthritis with anti-TNF antibodies comes with increased risk for malignancies and serious infections.
By Anna Wald, MD, MPH
July 13, 2006
Covering:
Bongartz T et al., JAMA 2006 May 17; 295:2275-85
Outcomes with Raloxifene in Women with Above-Average Coronary Risk
General Medicine Summary and Comment
Free
Raloxifene use reduces risk for breast cancer but introduces other potentially serious health concerns.
By Allan S. Brett, MD
July 13, 2006
Covering:
Barrett-Connor E et al., N Engl J Med 2006 Jul 13; 355:125-37
Stefanick ML., N Engl J Med 2006 Jul 13; 355:190-2
Progestogen-Only Contraception: Unlimited Use Remains Appropriate
General Medicine Summary and Comment
Bone-mineral density was lower in progestogen users than in nonusers, but the clinical significance of this finding isn’t clear.
By Robert W. Rebar, MD
July 13, 2006
Covering:
Curtis KM and Martins SL., Contraception 2006 May; 73:470-87
d’Arcangues C., Contraception 2006 May; 73:443-4
Necrotizing Soft Tissue Infections: Difficult to Diagnose in Immunocompromised Patients
The disorder may present differently in immunocompromised children.
By William P. Kanto, Jr., MD
June 29, 2006
Covering:
Butterworth SA and Murphy JJ., J Pediatr Surg 2006 May; 41:935-9
Osteomyelitis Treatment Gets Complicated
Young age and low income are associated with increased risk for catheter-associated complications.
By Cornelius W. Van Niel, MD
June 29, 2006
Covering:
Ruebner R et al., Pediatrics 2006 Apr; 117:1210-5
