Can Bisphosphonates Prevent Breast Cancer?
Women's Health Summary and Comment
Observational studies support the potential for chemoprophylaxis.
By Andrew M. Kaunitz, MD
July 15, 2010
Covering:
Rennert G et al., J Clin Oncol 2010 Jun 21
Chlebowski RT et al., J Clin Oncol 2010 Jun 21
Gnant M., J Clin Oncol 2010 Jun 21
Pathogenesis of Osteoarthritis
General Medicine Summary and Comment
We might have a new therapeutic target.
By Anthony L. Komaroff, MD
July 6, 2010
Covering:
Saito T et al., Nat Med 2010 Jun; 16:678
Yang S et al., Nat Med 2010 Jun; 16:687
Husa M et al., Nat Med 2010 Jun; 16:641
At What Level of Vitamin D Does Fracture Risk Rise?
General Medicine Summary and Comment
In older men, fracture risk was elevated only among those with serum 25-hydroxyvitamin D levels <16 ng/mL.
By Allan S. Brett, MD
June 24, 2010
Covering:
Melhus H et al., J Clin Endocrinol Metab 2010 Jun; 95:2637
Vitamin D Deficiency in Children and Adolescents
Vitamin D deficiency is prevalent in U.S. children, especially among blacks.
By Howard Bauchner, MD
June 16, 2010
Covering:
Freishtat RJ et al., J Pediatr 2010 Jun; 156:948
Dong Y et al., Pediatrics 2010 Jun; 125:1104
Denosumab Approved for Osteoporosis
Women's Health News in Context
Antibody suppresses bone turnover, thereby lowering fracture incidence; cost could be a concern.
For Proton-Pump Inhibitors and Fracture Risk, Not All Bones are Equal
Women's Health Summary and Comment
PPI use in postmenopausal women was associated with excess risk for clinical spine, forearm, or wrist fractures but not for hip fractures.
By Wendy S. Biggs, MD
June 10, 2010
Covering:
Gray SL et al., Arch Intern Med 2010 May 10; 170:765
Proton-Pump Inhibitor Dosing and Negative Consequences
General Medicine Summary and Comment
Free
Four studies about the effects of PPI therapy
By Jamaluddin Moloo, MD, MPH
June 8, 2010
Covering:
Wang C-H et al., Arch Intern Med 2010 May 10; 170:751
Gray SL et al., Arch Intern Med 2010 May 10; 170:765
Linsky A et al., Arch Intern Med 2010 May 10; 170:772
Howell MD et al., Arch Intern Med 2010 May 10; 170:784
Katz MH., Arch Intern Med 2010 May 10; 170:747
Single-Lens Distance Glasses Lower Risk for Falls in Active Older Wearers of Multifocal Glasses
General Medicine Summary and Comment
Single-lens distance glasses were most helpful for those who regularly engaged in outdoor activities.
How Much Sunlight Is Equivalent to Vitamin D Supplementation?
Dermatology Summary and Comment
Free
Now is the winter of our vitamin D discontent.
By Craig A. Elmets, MD
June 4, 2010
Covering:
Terushkin V et al., J Am Acad Dermatol 2010 Jun; 62:929
Tsiaras WG and Weinstock MA., J Am Acad Dermatol 2010 Jun; 62:935
Costs of Treatment: Fracture Prevention in Men Who Receive Androgen-Deprivation Therapy
Cost-effectiveness analysis in a hypothetical group of prostate cancer patients treated with ADT shows that osteoporosis screening and selective treatment might be valuable.
Proton-Pump Inhibitors and Osteoporotic Fractures
Gastroenterology Summary and Comment
PPI use was associated with spine and forearm or wrist fractures, but not hip fractures, in postmenopausal women.
Annual High-Dose Vitamin D and Fractures in Older Women
General Medicine Summary and Comment
Recipients incurred unexpected excess risk for fractures and falls.
Can Zoledronic Acid Help Avert Breast Cancer Metastasis?
Women's Health Summary and Comment
Intravenous bisphosphonate therapy might lower numbers of disseminated tumor cells in bone marrow of breast cancer patients.
Do Bisphosphonates Cause Atypical Femoral Fractures?
General Medicine Summary and Comment
Analysis provides reassurance about intermediate-term safety.
Accuracy of X-Rays for Detecting Hip and Pelvis Fractures
General Medicine Summary and Comment
Both false-positives and false-negatives are not uncommon.
By Allan S. Brett, MD
April 22, 2010
Covering:
Kirby MW and Spritzer C., AJR Am J Roentgenol 2010 Apr; 194:1054
Surgery for Lumbar Spinal Stenosis
General Medicine Summary and Comment
Complex fusion procedures for unclear indications are being performed more often, and complication rates are rising.
By Thomas L. Schwenk, MD
April 16, 2010
Covering:
Deyo RA et al., JAMA 2010 Apr 7; 303:1259
Carragee EJ., JAMA 2010 Apr 7; 303:1309
Bones Can Bounce Back
Bone-density loss in adolescents who use depot medroxyprogesterone acetate for contraception is reversible.
Rib Fracture Predicts Future Fractures in Older Men
General Medicine Summary and Comment
Low bone density and age
New Compression Device to Prevent Deep Venous Thrombosis
General Medicine Summary and Comment
In hip-replacement patients, a portable compression device was as effective as enoxaparin, without the bleeding complications.
By Allan S. Brett, MD
April 1, 2010
Covering:
Colwell CW Jr et al., J Bone Joint Surg Am 2010 Mar; 92:527
Leg-Length Inequality Is a Risk Factor for Osteoarthritis
General Medicine Summary and Comment
Inequality of
Possible Link Between Oral Bisphosphonates and Atypical Femur Fractures Is Far from Clear
Women's Health News in Context
FDA advises that patients who use bisphosphonates for osteoporosis can continue to do so.
Iron Supplementation for Anemia After Hip Fracture Surgery?
General Medicine Summary and Comment
Supplements impart no obvious benefit, and many patients experience adverse effects.
By Allan S. Brett, MD
March 4, 2010
Covering:
Parker MJ., J Bone Joint Surg Am 2010 Feb; 92:265
More Data on Fracture Risk with Thiazolidinediones
General Medicine Summary and Comment
Risk was particularly elevated among older women.
By Allan S. Brett, MD
March 2, 2010
Covering:
Habib ZA et al., J Clin Endocrinol Metab 2010 Feb; 95:592
New Selective Estrogen-Receptor Modulator for Treating Women with Osteoporosis?
Women's Health Summary and Comment
Lasofoxifene is unlikely to offer net benefits greater than those of existing therapies.
By Andrew M. Kaunitz, MD
February 24, 2010
Covering:
Cummings SR et al., N Engl J Med 2010 Feb 25; 362:686
Becker C., N Engl J Med 2010 Feb 25; 362:752
2010 NAMS Recommendations for Managing Osteoporosis in Postmenopausal Women
Women's Health Clinical Practice Guideline Watch
Free
Updates to the 2006 recommendations incorporate new findings.
