Vertebroplasty Isn't Effective for Vertebral Compression Fractures
General Medicine Summary and Comment
A meta-analysis showed no benefit over sham injection.
Multifaceted Podiatry Treatment of Foot Pain Prevents Falls in Elders
General Medicine Summary and Comment
Free
Intervention patients received appropriate footwear and a home-based foot and ankle exercise program.
Low Dietary Calcium Intake Raises Risk for Fracture and Osteoporosis
General Medicine Summary and Comment
During 19 years, first fracture of any type was significantly more common among women with low daily dietary calcium intake (
Surgery Doesn't Trump Rehabilitation in Patients with Degenerative Disk Disease
General Medicine Summary and Comment
Disk prosthesis surgery and nonsurgical rehabilitation led to clinically similar results.
Lateral Wedge Insoles Are Ineffective for Mild-to-Moderate Medial Knee Osteoarthritis
General Medicine Summary and Comment
At 1 year, no difference was found between wedge and flat insoles in knee pain or cartilage volume.
By Paul S. Mueller, MD, MPH, FACP
July 12, 2011
Covering:
Bennell KL et al., BMJ 2011 May 18; 342:d2912
Bierma-Zeinstra SMA., BMJ 2011 May 18; 342:d2860
Landmark Biomarker Studies Are Likely to Overstate Findings
Cardiology Summary and Comment
Results of frequently cited studies often differ markedly from those of meta-analyses or studies in larger populations.
By JoAnne M. Foody, MD
July 6, 2011
Covering:
Ioannidis JPA and Panagiotou OA., JAMA 2011 Jun 1; 305:2200
Bossuyt PMM., JAMA 2011 Jun 1; 305:2229
Predicting Fracture Risk in Patients with Type 2 Diabetes
General Medicine Summary and Comment
At similar bone-mineral densities, fracture risk was higher for diabetic patients.
All Common Thymidine-Sparing Regimens Induce Early Bone Loss
The greatest losses were seen with the combination of tenofovir/FTC + ritonavir-boosted atazanavir.
By Abigail Zuger, MD
June 20, 2011
Covering:
McComsey GA et al., J Infect Dis 2011 Jun 15; 203:1791
PPIs Might Decrease the Effectiveness of Alendronate to Prevent Fractures
Gastroenterology Summary and Comment
Concurrent use of proton-pump inhibitors blunted the efficacy of the bisphosphonate in reducing risk for hip fractures in patients aged 70 and older.
Levothyroxine and Fracture Risk in Elders
General Medicine Summary and Comment
Higher doses and current or recent use were associated with elevated risk.
By Paul S. Mueller, MD, MPH, FACP
May 17, 2011
Covering:
Turner MR et al., BMJ 2011 Apr 28; 342:d2238
Leese GP and Flynn RV., BMJ 2011 Apr 28; 342:d2250
Bisphosphonate-Related Jaw Osteonecrosis — Back on the Radar Screen
General Medicine Summary and Comment
Studies support a link between oral bisphosphonate use and jaw osteonecrosis, but absolute risk is very low.
By Allan S. Brett, MD
May 5, 2011
Covering:
Barasch A et al., J Dent Res 2011 Apr; 90:439
Fellows JL et al., J Dent Res 2011 Apr; 90:433
Bisphosphonates and Atypical Fractures: New Data from Sweden
Women's Health Summary and Comment
Free
Relative risk was higher among bisphosphonate users, but absolute risk was small; risk fell rapidly after drug discontinuation.
Prevention of Falls in Elders
General Medicine Summary and Comment
Effects of different interventions vary in different populations.
By Thomas L. Schwenk, MD
April 12, 2011
Covering:
Trombetti A et al., Arch Intern Med 2011 Mar 28; 171:525
Haines TP et al., Arch Intern Med 2011 Mar 28; 171:516
Denosumab for Bone Metastases from Advanced Prostate Cancer
Denosumab was superior to zoledronic acid in preventing skeletal-related events.
Lumbar Disk Herniation: Older vs. Younger Patients
General Medicine Summary and Comment
Outcomes of nonsurgical treatment were similar, regardless of age.
By Allan S. Brett, MD
March 29, 2011
Covering:
Suri P et al., J Am Geriatr Soc 2011 Mar; 59:423
Dental Implants After Oral Cancer Treatment
Osseointegration and long-term functionality were common after radiation therapy.
More on HIV-Related Fracture Risk
A large outpatient study confirms rates that are consistently higher than normal.
By Abigail Zuger, MD
March 28, 2011
Covering:
Young B et al., Clin Infect Dis 2011 Mar 10
A Huge Veterans Affairs Study Links HIV Infection to Elevated Fracture Risk
However, the association lost significance when other risk factors such as smoking, drinking, and low body-mass index were taken into account.
By Abigail Zuger, MD
March 14, 2011
Covering:
Womack JA et al., PLoS ONE 2011 Feb 16; 6:e17217
Nitroglycerin for Osteoporosis?
Women's Health Summary and Comment
A Canadian trial showed favorable skeletal effects, but headaches are a concern.
By Andrew M. Kaunitz, MD
March 10, 2011
Covering:
Jamal SA et al., JAMA 2011 Feb 23; 305:800
Khosla S., JAMA 2011 Feb 23; 305:826
More About Bisphosphonates and Atypical Femur Fractures
General Medicine Summary and Comment
Long-term bisphosphonate use was associated with a small increase in relative risk.
By Allan S. Brett, MD
March 3, 2011
Covering:
Park-Wyllie LY et al., JAMA 2011 Feb 23; 305:783
Primary Sclerosing Cholangitis and Bone Disease
Gastroenterology Summary and Comment
Age, body-mass index, and duration of inflammatory bowel disease were risk factors for osteoporosis in patients with PSC.
By Atif Zaman, MD, MPH
February 25, 2011
Covering:
Angulo P et al., Gastroenterology 2011 Jan; 140:180
Inhaled Corticosteroids Might Provoke Diabetes
General Medicine Summary and Comment
In an observational study, diabetes was more likely to develop in current steroid users.
Aromatase Inhibitors for Breast Cancer
Women's Health Patient Information
For menopausal women who develop breast cancer, drugs called aromatase inhibitors can prevent new or recurring breast cancer.
Aromatase Inhibitors as Adjuvant Therapy for Breast Cancer
A guide for women's health clinicians
Most Antiepilepsy Drugs Associated with Increased Fracture Risk
Most antiepileptic drugs confer an increased risk for nontraumatic fracture, according to a retrospective cohort study in the Archives of Neurology .
Using Canadian provincial healthcare...
