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Osteoporosis/Bone Disease: Archives

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Items 51-75 of 233 are shown

For Bones, Calcium Trumps Vitamin D

Supplementation with vitamin D plus calcium was of no additional benefit over calcium supplementation alone in older women with vitamin D insufficiency.

  • By Wendy S. Biggs, MD
  • September 18, 2008
  • Covering:
    • Zhu K et al., J Bone Miner Res 2008 Aug; 23:1343

Arthroscopic Surgery for Knee Osteoarthritis — No Benefit

No incremental improvement was observed when arthroscopic surgery was added to physical and medical therapy.

  • By Allan S. Brett, MD
  • September 16, 2008
  • Covering:
    • Kirkley A et al., N Engl J Med 2008 Sep 11; 359:1097

Use of Proton-Pump Inhibitors Is Associated with Excess Risk for Osteoporosis-Related Fractures

Notably, continuous PPI use for ≥5 years was associated with significant excess risk for hip fracture.

SSRIs May Break Bones

Two studies in older populations add to the evidence base.

  • By Steven Dubovsky, MD
  • September 15, 2008
  • Covering:
    • Bolton JM et al., J Clin Psychopharmacol 2008 Aug; 28:384
    • Ziere G et al., J Clin Psychopharmacol 2008 Aug; 28:411

Steroid Injections for Trigger Finger

Insulin-dependent diabetes mellitus was the only independent predictor of recurrent symptoms.

  • By Allan S. Brett, MD
  • August 28, 2008
  • Covering:
    • Rozental TD et al., J Bone Joint Surg Am 2008 Aug; 90:1665

Seeding Trials: Taking ADVANTAGE

A case study of a drug trial provides valuable evidence of a disturbing practice: the disguise of marketing schemes as scientific research.

  • By Joel M. Gore, MD
  • August 18, 2008
  • Covering:
    • Hill KP et al., Ann Intern Med 2008 Aug 19; 149:251
    • Sox HC and Rennie D., Ann Intern Med 2008 Aug 19; 149:279

Low-Molecular-Weight Heparin After Knee Arthroscopy

Heparin prophylaxis lowered risk for deep venous thrombosis.

Methotrexate plus Etanercept for Early, Moderate-to-Severe RA

Likelihood of remission and of radiographic nonprogression was greater with combination therapy than with methotrexate alone.

  • By Thomas L. Schwenk, MD
  • August 12, 2008
  • Covering:
    • Emery P et al., Lancet 2008 Aug 2; 372:375
    • Kremer JM., Lancet 2008 Aug 2; 372:347

UVA-1 for Sclerotic Skin Disease: More Is Not Better

A moderate approach balances the therapeutic efficacy of enough UVA-1 exposure against the tanning effects of too much exposure, which can block its benefits.

  • By Craig A. Elmets, MD
  • August 8, 2008
  • Covering:
    • Wang F et al., Arch Dermatol 2008 Jul; 144:851
    • Kreuter A and Gambichler T., Arch Dermatol 2008 Jul; 144:912

MRI Evaluation of Costal Cartilage Injuries

MRI is an appropriate modality on rare occasions.

  • By Allan S. Brett, MD
  • August 7, 2008
  • Covering:
    • Subhas N et al., AJR Am J Roentgenol 2008 Jul; 191:129

Exercise plus Amenorrhea Equals Thinner Bones

Adolescent endurance athletes with amenorrhea had significantly lower BMD <$EMPH_O>z<$EMPH_C> scores than did either eumenorrheic athletes or eumenorrheic nonathletes.

Rivaroxaban Is Superior to Enoxaparin for Thromboprophylaxis After Knee and Hip Arthroplasty

The results of three studies could usher in a new era of fixed-dose oral thromboprophylaxis.

  • By Paul S. Mueller, MD, MPH, FACP
  • July 24, 2008
  • Covering:
    • Lassen MR et al., N Engl J Med 2008 Jun 26; 358:2776
    • Kakkar AK et al., Lancet 2008 Jul 5; 372:31
    • Eriksson BI et al., N Engl J Med 2008 Jun 26; 358:2765

Psoriatic Arthritis in Patients Treated with Efalizumab

Sixteen patients in a group of 450 efalizumab recipients developed joint manifestations.

Simplified Thromboprophylaxis with Rivaroxaban After Hip Surgery

Results of a large randomized trial demonstrate the efficacy, safety, and convenience of a once-daily regimen of an oral factor Xa inhibitor.

  • By Beat J. Meyer, MD
  • July 16, 2008
  • Covering:
    • Kakkar AK et al. for the RECORD2 Investigators., Lancet 2008 Jul 5; 372:31
    • Eikelboom JW and Weitz JI., Lancet 2008 Jul 5; 372:6

Surgery vs. Nonoperative Treatment for Sciatica: Follow-Up After 2 Years

Short-term results were better with surgery, but outcomes were similar between groups at 1 year and 2 years.

Phenytoin and Bone Health

Phenytoin monotherapy was associated with lower femoral neck BMD.

  • By Ann J. Davis, MD
  • June 26, 2008
  • Covering:
    • Pack A et al., Neurology 2008 Apr 29; 70:1586

Thiazolidinediones and Fracture Risk in Diabetic Women

Fracture risk was higher in diabetic women treated with thiazolidinediones than in those taking other antidiabetic drugs.

  • By Diane E. Judge, APN/CNP
  • June 26, 2008
  • Covering:
    • Kahn SE et al., Diabetes Care 2008 May; 31:845
    • Meier C et al., Arch Intern Med 2008 Apr 28; 168:820

Rivaroxaban for Thromboprophylaxis After Joint Replacement

In two large, randomized studies, rivaroxaban was superior to enoxaparin in preventing venous thrombosis.

  • By David Green, MD, PhD
  • June 25, 2008
  • Covering:
    • Eriksson BI et al., N Engl J Med 2008 Jun 26; 358:2765
    • Lassen MR et al., N Engl J Med 2008 Jun 26; 358:2776

Angiotensin-Receptor Blockers and Marfan Syndrome

Results of a small, preliminary study of the effects of ARBs on abnormal aortic root enlargement are quite promising.

Vitamin D Deficiency in Young Children

Suboptimal vitamin D levels were common in healthy infants and toddlers.

  • By Howard Bauchner, MD
  • June 24, 2008
  • Covering:
    • Gordon CM et al., Arch Pediatr Adolesc Med 2008 Jun; 162:505
    • Taylor JA., Arch Pediatr Adolesc Med 2008 Jun; 162:583

Is Congestive Heart Failure Triggered or Treated by Inhibition of TNF?

Patients with severe rheumatoid arthritis, especially those with highly active disease, are at high risk for development or worsening of heart failure.

  • By Deborah M. DeMarco, MD
  • June 24, 2008
  • Covering:
    • Listing J et al., Arthritis Rheum 2008 Mar; 58:667

Long-Term Clinical and Immunological Effects of Anti-CD20 Treatment in Refractory SLE

Anti-CD20 treatment could be beneficial for treatment of patients with refractory lupus nephritis and autoimmune cytopenias.

  • By Deborah M. DeMarco, MD
  • June 24, 2008
  • Covering:
    • Lindholm C et al., J Rheumatol 2008 May; 35:826

Prednisolone Is as Effective as Naproxen for Acute Gout

A 5-day course of oral prednisolone is a reasonable alternative to NSAIDs for treating patients with acute gouty arthritis.

  • By Bruce Soloway, MD
  • June 17, 2008
  • Covering:
    • Janssens HJEM et al., Lancet 2008 May 31; 371:1854

Impact of Antiepileptic Therapy on Bone-Mineral Density in Young Women

Phenytoin — but not carbamazepine, lamotrigine, or valproate — reduced bone-mineral density at the femoral neck over a 1-year period.

  • By Carolyn B. Becker, MD
  • June 17, 2008
  • Covering:
    • Pack AM et al., Neurology 2008 Apr 29; 70:1586

Oral Prednisolone for Gout

Oral prednisolone is as safe and effective as naproxen.

  • By Kristi L. Koenig, MD, FACEP
  • June 13, 2008
  • Covering:
    • Janssens HJEM et al., Lancet 2008 May 31; 371:1854
    • Rainer TH and Graham CA., Lancet 2008 May 31; 371:1816
Items 51-75 of 233 are shown

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