Fracture Risk After Bariatric Surgery
General Medicine Summary and Comment
Risk was not increased in the short term, but trended higher 3 to 5 years after surgery.
How Obesity, Diabetes, and Infection Interact After Total Joint Replacement
General Medicine Summary and Comment
Periprosthetic infection was associated with severe obesity and, to a lesser extent, diabetes.
By Allan S. Brett, MD
August 16, 2012
Covering:
Jämsen E et al., J Bone Joint Surg Am 2012 Jul 18; 94:e1011
Hip Fracture Is Less Likely After Cataract Surgery
General Medicine Summary and Comment
Risk was 16% lower within 1 year after cataract removal.
Low Bone Mass Observed in Young Men with Recently Acquired HIV Infection
Recently infected young men receiving antiretroviral therapy had modestly lower bone mass than their uninfected peers.
By Keith Henry, MD
July 30, 2012
Covering:
Mulligan K et al., Clin Infect Dis 2012 Aug 1; 55:461
Newer Oral Anticoagulants Are as Efficacious as Enoxaparin in Preventing Symptomatic Venous Thromboembolism
General Medicine Summary and Comment
In a meta-analysis of patients who underwent hip or knee arthroplasty, rivaroxaban, dabigatran, and apixaban all performed well.
Initial Bone and Joint Cultures Improve Outpatient Management of Musculoskeletal Infection
Cultures from the infection site were twice as likely as blood cultures to identify the causative organism, and identification of the causative pathogen was associated with discharge on a single oral antibiotic.
Vitamin D Supplementation Prevents Fractures
General Medicine Summary and Comment
A meta-analysis suggests benefit at a dose of >800 IU daily, but factors relating to treatment adherence could have biased the results
By Allan S. Brett, MD
July 10, 2012
Covering:
Bischoff-Ferrari HA et al., N Engl J Med 2012 Jul 5; 367:40
Heaney RP. , N Engl J Med 2012 Jul 5; 367:77
Atypical Femoral Fractures — Are They Associated with Bisphosphonate Therapy, and Why Should a Dermatologist Care?
Dermatology Summary and Comment
Dermatologists should discuss the benefits and risks of therapy versus nontreatment with patients receiving systemic corticosteroids.
By Jeffrey P. Callen, MD
June 15, 2012
Covering:
Meier RPH et al., Arch Intern Med 2012 May 21
Bauer DC., Arch Intern Med 2012 May 21
Adult Stem Cell Therapy Treats Osteoarthritis in Mice
General Medicine Summary and Comment
Kartogenin promotes formation of new cartilage.
How Do Specific Antiretrovirals Affect Fracture Risk?
The jury is still out.
Bisphosphonate Use Raises Risk for Atypical Femoral Fracture
General Medicine Summary and Comment
But absolute risk was still small.
By Thomas L. Schwenk, MD
June 7, 2012
Covering:
Meier RPH et al., Arch Intern Med 2012 May 21
Bauer DC., Arch Intern Med 2012 May 21
New Bisphosphonate Use Associated with Uveitis and Scleritis
General Medicine Summary and Comment
This side effect is not well known, but it's potentially serious.
A Molecule Protects and Restores Bone Density in Mice
General Medicine Summary and Comment
Could this discovery lead to better osteoporosis therapy in humans?
By Anthony L. Komaroff, MD
June 7, 2012
Covering:
Hayashi M et al., Nature 2012 May 3; 485:69
Zaidi M and Iqbal J., Nature 2012 May 3; 485:47
When Is Prolonged Bisphosphonate Treatment for Osteoporosis Appropriate?
Women's Health Practice Watch
Mixed results from trials of extended bisphosphonate treatment leave treatment and monitoring guidelines uncertain.
More Evidence that Tenofovir Leads to Bone Loss
Patients who switched to tenofovir from AZT experienced significant decreases in BMD. Those who switched to abacavir did not.
Optimizing Postmenopausal Vitamin D3 Supplementation
General Medicine Summary and Comment
For white women, 600 IU of vitamin D3 daily appears to be sufficient.
One-Year Function Similar After Resurfacing Hip Arthroplasty or Total Hip Arthroplasty
General Medicine Summary and Comment
Overall complication rates did not differ between groups.
What's the Incidence of Venous Thromboembolism After Knee Arthroscopy?
General Medicine Summary and Comment
Incidence was 0.40% in this large cohort study.
By Allan S. Brett, MD
April 24, 2012
Covering:
Maletis GB et al., J Bone Joint Surg Am 2012 Apr 18; 94:714
Antiretrovirals and Fracture Risk: More Clues
Among patients who entered care after the introduction of potent ART, tenofovir and boosted protease inhibitors were each associated with modest increases in fracture risk.
Revisiting Variability in Measurement of Vitamin D Levels
General Medicine Summary and Comment
On average, serum 25-hydroxyvitamin D levels differed by 5 ng/mL across two assays.
By Allan S. Brett, MD
April 10, 2012
Covering:
Barake M et al., J Clin Endocrinol Metab 2012 Mar; 97:835
Preventing Osteoporotic Fractures in Women Who Receive Aromatase Inhibitors
Women's Health Summary and Comment
A cost-effectiveness model suggested bisphosphonates should be used only when BMD assessment shows elevated fracture risk.
By Andrew M. Kaunitz, MD
March 29, 2012
Covering:
Ito K et al., J Clin Oncol 2012 Feb 27
Dhesy-Thind SK., J Clin Oncol 2012 Feb 27
PPI Use Associated with Hip-Fracture Risk in Postmenopausal Women
Gastroenterology Summary and Comment
Free
Data from a large, prospective cohort study showed risk to be highest in smokers and in women with lengthy PPI use.
Vitamin D and Calcium Supplementation in Older Adults
General Medicine Summary and Comment
A randomized trial found no effect on cancer or vascular mortality.
By Allan S. Brett, MD
March 13, 2012
Covering:
Avenell A et al., J Clin Endocrinol Metab 2012 Feb; 97:614
Remote-Controlled Medicine
General Medicine Summary and Comment
An implanted chip releases drugs on wireless command.
Lactose Malabsorption in Children Is Not Associated with Lower Calcium Intake or Bone Mass
Lactose absorbers and malabsorbers have the same calcium intake and bone density.
By Cornelius W. Van Niel, MD
February 22, 2012
Covering:
da Silva Medeiros LC et al., J Pediatr Gastroenterol Nutr 2012 Feb; 54:204
