Does Early Statin Use After ACS Improve Major Outcomes?
Cardiology Summary and Comment
Not according to a meta-analysis of trials in which LDL lowering was mostly moderate
By JoAnne M. Foody, MD
June 8, 2006
Covering:
Briel M et al., JAMA 2006 May 3; 295:2046-56
Intensive Lipid Lowering in Obese Patients
Cardiology Summary and Comment
Insights from the REVERSAL trial
By Joel M. Gore, MD
July 5, 2006
Covering:
Nicholls SJ et al., Am J Cardiol 2006 Jun 1; 97:1553-7
High-Intensity Statin Therapy Leads to Regression of Coronary Atherosclerosis
Emergency Medicine Summary and Comment
Changes occurred after 2 years of statin therapy.
By John A. Marx, MD, FAAEM, FACEP
May 23, 2006
Covering:
Nissen SE et al., JAMA 2006 Apr 5; 295:1556-65
Blumenthal RS and Kapur NK., JAMA 2006 Apr 5; 295:1583-4
Modifying Therapy When CV Risk Factors Are Poorly Controlled
Cardiology Summary and Comment
Free
Assessing appropriate therapy modification by clinicians might be a way to measure quality of care.
By Joel M. Gore, MD
May 4, 2006
Covering:
Rodondi N et al., Ann Intern Med 2006 Apr 4; 144:475-84
Perlin JB and Pogach LM., Ann Intern Med 2006 Apr 4; 144:525-7
Variations in Low-LDL Gene Linked with Reduced CHD Risk
Cardiology Summary and Comment
Risk was particularly low in black carriers.
By Harlan M. Krumholz, MD, SM
April 27, 2006
Covering:
Cohen JC et al., N Engl J Med 2006 Mar 23; 354:1264-72
Tall AR., N Engl J Med 2006 Mar 23; 354:1310-2
Negative Findings for ACAT Inhibition
Cardiology Summary and Comment
Pactimibe did not inhibit atherosclerosis progression.
By Harlan M. Krumholz, MD, SM
April 27, 2006
Covering:
Nissen SE et al. for the ACAT Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Investigators., N Engl J Med 2006 Mar 23; 354:1253-63
Fazio S and Linton M., N Engl J Med 2006 Mar 23; 354:1307-9
High-Intensity Lipid Lowering Reduces Atheroma Volume
Cardiology Summary and Comment
High-dose rosuvastatin achieved regression of atheroma in a small study without a control group.
By JoAnne M. Foody, MD
April 27, 2006
Covering:
Nissen SE et al. for the ASTEROID Investigators., JAMA 2006 Apr 5; 295:1556-65
Blumenthal RS and Kapur NK., JAMA 2006 Apr 5; 295:1583-4
Improving Aging with Lipid-Lowering Drugs
Dermatology Summary and Comment
In a mouse model of progeria, enzyme inhibition reduced signs of premature aging.
By Hensin Tsao, MD, PhD
April 25, 2006
Covering:
Fong LG et al., Science 2006 Mar 17; 311:1621-3
Cost-Effectiveness of Primary-Prevention Therapy with Aspirin plus Statins
Cardiology Summary and Comment
For a healthy middle-aged man, the cost-effectiveness of combination therapy depends on his 10-year Framingham risk for cardiovascular events.
By Joel M. Gore, MD
April 6, 2006
Covering:
Pignone M et al., Ann Intern Med 2006 Mar 7; 144:326-36
Low-Carb vs. Low-Fat Diets: A Meta-Analysis
Cardiology Summary and Comment
Both types of diets yielded similar weight loss at 12 months, but each had different effects on serum lipids.
By Frederick A. Masoudi, MD, MSPH
March 30, 2006
Covering:
Nordmann AJ et al., Arch Intern Med 2006 Feb 13; 166:285-93
Statin Use and Mortality in HF Patients
Cardiology Summary and Comment
Elders who received a statin at hospital discharge survived longer, an observational study found.
By William T. Abraham, MD
March 30, 2006
Covering:
Foody JM et al., Circulation 2006 Feb 28; 113:1086-92
Are Statins Beneficial After MI in Elders?
Cardiology General Medicine
These findings raise questions about the effectiveness of statins in patients age 80 or older.
By Allan S. Brett, MD
March 30, 2006
Covering:
Foody JM et al., J Am Geriatr Soc 2006 Mar; 54:421-30
Polylactic Acid Improves Appearance and Quality of Life in HIV-Related Lipodystrophy Syndrome
Dermatology Summary and Comment
A simple, life-altering treatment
By Jeffrey S. Dover MD, FRCPC
March 28, 2006
Covering:
Cattelan AM et al., Arch Dermatol 2006 Mar; 142:329-34
Are Statins Beneficial After MI in Elders?
General Medicine Summary and Comment
These findings raise questions about the effectiveness of statins in patients older than 80.
By Allan S. Brett, MD
March 17, 2006
Covering:
Foody JM et al., J Am Geriatr Soc 2006 Mar; 54:421-30
Statins and ß-Blockers Can Favorably Alter Initial CHD Presentation
General Medicine Summary and Comment
Patients who took statins and ß-blockers were more likely to present with angina than MI.
By Richard Saitz, MD, MPH, FACP, FASAM
March 14, 2006
Covering:
Go AS et al., Ann Intern Med 2006 Feb 21; 144:229-38
Statins Do Not Affect Cancer Risk
Cardiology Summary and Comment
A meta-analysis of randomized controlled trials showed no effect on any type of cancer by any type of statin.
By JoAnne M. Foody, MD
March 9, 2006
Covering:
Dale KM et al., JAMA 2006 Jan 4; 295:74-80
Statins Might Prevent Sepsis in Older Patients with Atherosclerosis
Cardiology General Medicine
A population-based analysis revealed significantly lower rates of sepsis with statin use; randomized trials would be required to determine whether statins might be used specifically to prevent sepsis.
By Bruce Soloway, MD
March 9, 2006
Covering:
Hackam DG et al., Lancet 2006 Feb 4; 367:413-8
Statins Might Prevent Sepsis in Older Patients with Atherosclerosis
General Medicine Summary and Comment
A population-based analysis revealed significantly lower rates of sepsis with statin use; randomized trials would be required to determine whether statins might be used specifically to prevent sepsis.
By Bruce Soloway, MD
March 3, 2006
Covering:
Hackam DG et al., Lancet 2006 Feb 4; 367:413-8
Dietary Modification and CVD Outcomes in the WHI
Cardiology Summary and Comment
Free
A dietary intervention that focused on total fat intake, rather than more-specific dietary dimensions, did not improve cardiovascular outcomes in postmenopausal women.
By JoAnne M. Foody, MD
February 23, 2006
Covering:
Howard BV et al., JAMA 2006 Feb 8; 295:655-66
Anderson CM and Appel LJ., JAMA 2006 Feb 8; 295:693-5
Weight Loss with a Low-Fat, High-Carb Diet in Postmenopausal Women
Cardiology Summary and Comment
Insights from the Women’s Health Initiative Dietary Modification Trial
By JoAnne M. Foody, MD
February 23, 2006
Covering:
Howard BV et al., JAMA 2006 Jan 4; 295:39-49
Statins for Nonischemic HF?
Cardiology Summary and Comment
Two randomized trials tested atorvastatin in patients with heart failure not due to coronary disease.
By Frederick A. Masoudi, MD, MSPH
February 23, 2006
Covering:
Sola S et al., J Am Coll Cardiol 2006 Jan 17; 47:332-7
Bleske BE et al., J Am Coll Cardiol 2006 Jan 17; 47:338-41
Ramasubbu K and Mann DL., J Am Coll Cardiol 2006 Jan 17; 47:342-4
Statins for Patients with Nonischemic Heart Failure?
General Medicine Summary and Comment
Statins might improve LVEF and halt LV enlargement.
By Kirsten E. Fleischmann, MD, MPH
February 17, 2006
Covering:
Sola S et al., J Am Coll Cardiol 2006 Jan 17; 47:332-7
Ramasubbu K and Mann DL., J Am Coll Cardiol 2006 Jan 17; 47:342-4
Obesity in Middle Age Portends Poor Outcomes in Older Age
Cardiology Summary and Comment
Insights from the Chicago Heart Association Detection Project in Industry
By JoAnne M. Foody, MD
February 16, 2006
Covering:
Yan LL et al., JAMA 2006 Jan 11; 295:190-8
Metabolic Syndrome Predicts NAFLD
Gastroenterology Summary and Comment
Prospective data suggest that the metabolic syndrome significantly increases NAFLD risk, particularly among women.
By Atif Zaman, MD, MPH
February 14, 2006
Covering:
Hamaguchi M et al., Ann Intern Med 2005 Nov 15; 143:722-8
For Men, Dyslipidemia Now Might Mean High BP Later
Cardiology Summary and Comment
Insights from the Physicians’ Health Study
By Joel M. Gore, MD
January 26, 2006
Covering:
Halperin RO et al., Hypertension 2006 Jan; 47:45-50
