Inadequate Secondary Prevention After Stroke
Neurology Summary and Comment
Secondary prevention efforts are inadequate despite the high risk for secondary cardiovascular events among survivors of either myocardial infarction or stroke.
By Adnan I. Qureshi, MD
October 3, 2006
Covering:
Cheng E et al., Cerebrovasc Dis 2006 Mar; 21:235-41
CCB vs. ACE Inhibitor in High-Risk Hypertension
Cardiology Summary and Comment
A new ALLHAT analysis reveals that amlodipine has some outcome advantages over lisinopril.
By Joel M. Gore, MD
September 27, 2006
Covering:
Leenen FH et al., Hypertension 2006 Sep; 48:374-84
Messerli FH and Staessen JA., Hypertension 2006 Sep; 48:359-61
Antiangiogenic Markers of Preeclampsia
Cardiology Summary and Comment
Could measurement of circulating levels of certain antiangiogenic proteins someday identify women at high risk for preeclampsia?
By Harlan M. Krumholz, MD, SM
September 27, 2006
Covering:
Levine RJ et al., N Engl J Med 2006 Sep 7; 355:992-1005
Lindheimer M and Umans JG., N Engl J Med 2006 Sep 7; 355:1056-8
Hypertension in Kidney Donors
General Medicine Summary and Comment
This meta-analysis suggests that blood pressure increases after kidney donation.
By Richard Saitz, MD, MPH, FACP, FASAM
September 14, 2006
Covering:
Boudville N et al., Ann Intern Med 2006 Aug 1; 145:185-96
Involving Patients in Their Own Care Improves BP Control
General Medicine Summary and Comment
. . .but the reason for the improvement is not clear.
By Richard Saitz, MD, MPH, FACP, FASAM
September 12, 2006
Covering:
Roumie CL et al., Ann Intern Med 2006 Aug 1; 145:165-75
Can a Hormone Therapy Combat Hypertension?
Women's Health Summary and Comment
Promise but caution: Drospirenone reduced blood pressure in postmenopausal women.
By Marian C. Limacher, MD
August 31, 2006
Covering:
White WB et al., Hypertension 2006 Aug; 48:246-53
Sica DA., Hypertension 2006 Aug; 48:205-6
Guidelines on Secondary Prevention of Ischemic Stroke
Neurology Clinical Practice Guideline Watch
Free
Updated guidelines from the American Heart Association and the American Stroke Association
By Steven Feske, MD
August 29, 2006
Covering:
Sacco RL et al., Stroke 2006 Feb; 37:577-617
Blood Pressure and the J-Curve Phenomenon
General Medicine Summary and Comment
In patients with hypertension and coronary artery disease, a J-curve was evident for the relation between BP and adverse outcomes, but the relation was attenuated after adjustment for baseline factors.
By Jamaluddin Moloo, MD, MPH
August 10, 2006
Covering:
Messerli FH et al., Ann Intern Med 2006 Jun 20; 144:884-93
Can an ARB Reduce BP and CRP Levels?
Cardiology Summary and Comment
Valsartan reduced C-reactive protein levels, independent of its BP-lowering effect, in a trial that lacked a non-ARB control group.
By Joel M. Gore, MD
August 9, 2006
Covering:
Ridker PM et al. for the Val-MARC Investigators., Hypertension 2006 Jul; 48:73-9
Treat Hypertension, Prevent Dementia?
Neurology Summary and Comment
An observational study of older men raises the possibility of such a benefit if treatment lasts at least 5 years.
By Farzaneh A. Sorond, MD, PhD
August 1, 2006
Covering:
Peila R et al., Stroke 2006 May; 37:1165-70
C-Reactive Protein: Not Ready for Population-Wide CVD Risk Assessment
General Medicine Summary and Comment
Free
Traditional risk factors alone are still the best predictors of CVD risk.
By Jamaluddin Moloo, MD, MPH, and Richard Saitz, MD, MPH, FACP, FASAM
July 27, 2006
Covering:
Cook NR et al., Ann Intern Med 2006 Jul 4; 145:21-9
Folsom AR et al., Arch Intern Med 2006 Jul 10; 166:1368-73
Lloyd-Jones DM et al., Ann Intern Med 2006 Jul 4; 145:35-42
Davey Smith G et al., Ann Intern Med 2006 Jul 4; 145:70-2
Lloyd-Jones DM and Tian L., Arch Intern Med 2006 Jul 10; 166:1342-4
ACE Inhibitors and Birth Defects: Unsafe in Any Trimester
Women's Health Summary and Comment
Free
Treatment with ACE inhibitors increases risk for major malformations when used in the first trimester as well as later in pregnancy.
By Andrew M. Kaunitz, MD
July 13, 2006
Covering:
Cooper WO et al., N Engl J Med 2006 Jun 8; 354:2443-51
Friedman JM., N Engl J Med 2006 Jun 8; 354:2498-500
Which Comes First, Cardiac Risk or Menopause?
Women's Health Summary and Comment
Increases in cardiac risk factors are associated with earlier menopause.
By Marian C. Limacher, MD
July 13, 2006
Covering:
Kok HS et al., J Am Coll Cardiol 2006 May 16; 47:1976-83
Bittner V., J Am Coll Cardiol 2006 May 16; 47:1984-6
Diastolic BP in Patients with CAD: How Low Is Too Low?
Cardiology Summary and Comment
Baseline diastolic BP had a J-shaped relation with risks for death and MI among CAD patients treated with antihypertensive drugs in the INVEST trial.
By Joel M. Gore, MD
July 12, 2006
Covering:
Messerli FH et al., Ann Intern Med 2006 Jun 20; 144:884-93
Nighttime BP and Risk for Heart Failure
Cardiology Summary and Comment
Nighttime blood pressure as high as, or higher than, daytime BP was associated with increased risk for heart failure.
By Frederick A. Masoudi, MD, MSPH
July 12, 2006
Covering:
Ingelsson E et al., JAMA 2006 Jun 28; 295:2859-66
Another Look at ß-Blockers for Hypertension
General Medicine Summary and Comment
ß-blockers might be more acceptable first-line drugs for younger hypertensive patients than for older patients.
By Allan S. Brett, MD
June 23, 2006
Covering:
Khan N and McAlister FA., CMAJ 2006 Jun 6; 174:1737-42
Blood Pressure and Mortality in the Very Old
General Medicine Summary and Comment
Free
Patients with systolic BP <140 mm Hg had significantly increased all-cause mortality risk.
By Allan S. Brett, MD
June 27, 2006
Covering:
Rastas S et al., J Am Geriatr Soc 2006 Jun; 54:912-8
Ethnicity Affects Reactions to Cardiovascular Drugs
General Medicine Summary and Comment
Possible associations between ADRs and ethnicity should be examined in studies of new drugs.
By Keith I. Marton, MD
June 23, 2006
Covering:
McDowell SE et al., BMJ 2006 May 20; 332:1177-80
Eliasson E., BMJ 2006 May 20; 332:1163-4
ACE Inhibitors Are Teratogenic in the First Trimester
Cardiology Summary and Comment
Free
Specifically, these drugs were associated with increased infant risks for cardiovascular and nervous system anomalies.
By Harlan M. Krumholz, MD, SM
July 5, 2006
Covering:
Cooper WO et al., N Engl J Med 2006 Jun 8; 354:2443-51
Friedman JM., N Engl J Med 2006 Jun 8; 354:2498-500
Which Antihypertensive Best Prevents HF in Patients with High BP?
Cardiology Summary and Comment
Free
ALLHAT data bolster the case for diuretic-based therapy.
By Frederick A. Masoudi, MD, MSPH
June 1, 2006
Covering:
Davis BR et al., Circulation 2006 May 9; 113:2201-10
Yusuf S., Circulation 2006 May 9; 113:2166-8
Antihypertensive Drugs and Risk for Diabetes
General Medicine Summary and Comment
Free
Prospective data from three large cohorts add to the evidence that thiazide diuretics and ß-blockers can cause glucose intolerance.
By Allan S. Brett, MD
May 30, 2006
Covering:
Taylor EN et al., Diabetes Care 2006 May; 29:1065-70
Association of Diabetes and Hypertension with Shock-Wave Lithotripsy
Trauma to the kidneys and pancreas may explain the finding of a long-term risk.
By F. Bruder Stapleton, MD
May 26, 2006
Covering:
Krambeck AE et al., J Urol 2006 May; 175:1742-7
Can Treating Hypertension Lower the Risk for Dementia?
Cardiology Summary and Comment
Long-term BP-lowering treatment was associated with reduced risk for dementia in an observational study of Japanese American men.
By Joel M. Gore, MD
May 18, 2006
Covering:
Peila R et al., Stroke 2006 May; 37:1165-70
Brust JCM., Stroke 2006 May; 37:1146
ACE Inhibitors for Stable CAD Without LVSD: A Meta-Analysis
Cardiology Summary and Comment
Findings should lessen concerns raised by the PEACE trial.
By Frederick A. Masoudi, MD, MSPH
May 11, 2006
Covering:
Danchin N et al., Arch Intern Med 2006 Apr 10; 166:787-96
Antihypertensive Drugs and Development of Diabetes in Blacks
General Medicine Summary and Comment
Ramipril was associated with significantly lower risk for diabetes than was metoprolol or amlodipine.
By Jamaluddin Moloo, MD, MPH
May 9, 2006
Covering:
Thornley-Brown D et al., Arch Intern Med 2006 Apr 10; 166:797-805
