Minimizing Risk for Aspirin-Associated GI Complications in CVD Patients
Gastroenterology Summary and Comment
Free
Most patients who receive aspirin for cardioprotection are at risk for aspirin-associated GI complications, but only about 25% receive PPIs or misoprostol to reduce this risk.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
May 9, 2006
Covering:
Targownik LE and Al-Mamfud A., Aliment Pharmacol Ther 2006 Mar 15; 23:743-9
Combined Injection and PPI Therapy for Bleeding Ulcers
Gastroenterology Summary and Comment
Epinephrine injection plus high-dose omeprazole therapy was superior to injection plus cimetidine therapy for preventing ulcer rebleeding.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
May 9, 2006
Covering:
Lin HJ et al., Am J Gastroenterol 2006 Mar; 101:500-5
Esomeprazole to Prevent NSAID-Induced Ulcers
General Medicine Summary and Comment
A proton-pump inhibitor reduced the incidence of endoscopically defined ulcers among high-risk patients who took either nonselective NSAIDs or COX-2 inhibitors.
By Allan S. Brett, MD
April 28, 2006
Covering:
Scheiman JM et al., Am J Gastroenterol 2006 Apr 3; 101:701-10
Mechanism for the Association Between Obesity and GERD
Gastroenterology Summary and Comment
Pressure derangements at the EGJ, which are associated with obesity, augment reflux.
By David A. Johnson, MD
April 25, 2006
Covering:
Pandolfino JE et al., Gastroenterology 2006 Mar; 130:639-49
Atazanavir with PPIs: Are They Always Contraindicated?
In one brief report, atazanavir levels were not substantially influenced by PPIs; in another, virologic failure rates did not increase. However, both studies were too small to warrant a change in the recommendation to avoid concomitant use.
By G. Sonia Nagy, MD
April 12, 2006
Covering:
Guiard-Schmid J-B et al., J Acquir Immune Defic Syndr 2006 Mar; 41:393-4
Furtek KJ et al., J Acquir Immune Defic Syndr 2006 Mar; 41:394-6
Chronic Medication Use After Antireflux Surgery
Gastroenterology Summary and Comment
Free
About half of all patients who undergo antireflux surgery require sustained use of antireflux medications.
By David A. Johnson, MD
April 11, 2006
Covering:
Dominitz JA et al., Clin Gastroenterol Hepatol 2006 Mar; 4:299-305
Endoscopic Findings with Antithrombotic Therapy
Gastroenterology Summary and Comment
Erosive esophagitis was an important cause of bleeding in patients who took antithrombotic drugs.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
April 11, 2006
Covering:
Taha AS et al., Aliment Pharmacol Ther 2006 Feb 15; 23:489-95
How Often Is GERD the Cause of Suspected Laryngopharyngeal Reflux?
Gastroenterology Summary and Comment
Free
Acid-suppressive agents were no more beneficial than placebo in patients with suspected reflux laryngitis.
By David A. Johnson, MD
March 14, 2006
Covering:
Vaezi MF et al., Laryngoscope 2006 Feb; 116:254-60
Acid-Suppressive Meds Linked to C. difficile –Associated Diarrhea
Emergency Medicine Summary and Comment
Use of PPIs and H2 -blockers significantly raises risk for CDAD.
By John A. Marx, MD, FAAEM, FACEP
March 14, 2006
Covering:
Dial S et al., JAMA 2005 Dec 21; 294:2989-95
Does Community H. pylori Screening and Treatment Reduce Dyspepsia Symptoms?
General Medicine Summary and Comment
Community screening led to a reduction in consultations for dyspepsia, but at a cost.
By Keith I. Marton, MD
March 7, 2006
Covering:
Lane JA et al., BMJ 2006 Jan 28; 332:199-204
Delaney BC., BMJ 2006 Jan 28; 332:187-8
H2 -Blockers and Necrotizing Enterocolitis in VLBW Infants
General Medicine Summary and Comment
H2 -blockers should be used sparingly in very-low-birth-weight infants.
By Howard Bauchner, MD
February 28, 2006
Covering:
Guillet R et al., Pediatrics 2006 Feb
When Do GERD Patients Go to Bed?
Gastroenterology Summary and Comment
Compared with people who don’t have GERD, GERD patients have shorter intervals between dinner and bedtime.
By David A. Johnson, MD
February 28, 2006
Covering:
Fujiwara Y et al., Am J Gastroenterol 2005 Dec; 100:2633-6
Effect of H. pylori Eradication on NSAID-Associated GI Symptoms
Gastroenterology Summary and Comment
Short-term GI tolerance of NSAIDs is similar among patients with or without <$EMPH_O>H. pylori<$EMPH_C> infections, whether or not such infections are treated.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
February 14, 2006
Covering:
Schaeverbeke T et al., Am J Gastroenterol 2005 Dec; 100:2637-43
Treating GERD-Associated Cough
General Medicine Summary and Comment
PPIs might relieve cough in some patients, but strong evidence of their effectiveness is lacking.
By Keith I. Marton, MD
February 14, 2006
Covering:
Chang AB et al., BMJ 2006 Jan 7; 332:11-7
Gastric-Acid–Suppressive Agents Increase Risk for C. difficile -Associated Disease
The association between CDAD and gastric-acid suppression in adults may be relevant in kids.
By F. Bruder Stapleton, MD
February 10, 2006
Covering:
Dial S et al., JAMA 2005 Dec 21; 294:2989-95
Acid Reflux Event Detection
Gastroenterology Summary and Comment
The Slimline catheter pH system recorded threefold more acid reflux events than did the Bravo wireless system.
By David A. Johnson, MD
January 17, 2006
Covering:
Pandolfino JE et al., Gut 2005 Dec; 54:1687-92
Gastric-Acid Suppression and Risk for Community-Acquired C. difficile– Associated Disease
Gastroenterology Summary and Comment
Use of PPIs, H2 -blockers, and NSAIDs increase risk for <$EMPH_O>C. difficile–<$EMPH_C>associated disease, but the mechanism underlying these effects remains unknown.
By David A. Johnson, MD
January 17, 2006
Covering:
Dial S et al., JAMA 2005 Dec 21; 294:2989-95
C. difficile Risk and Gastric Acid Suppression
Infectious Diseases Summary and Comment
The use of proton-pump inhibitors and H2 -blockers more than doubles the risk for community-acquired <$EMPH_O>C. difficile<$EMPH_C> disease.
By Richard T. Ellison III, MD
January 13, 2006
Covering:
Dial S et al., JAMA 2005 Dec 21; 294:2989-95
PPIs and H2 -Blockers Augment Risk for C. Difficile –Associated Disease
General Medicine Summary and Comment
Free
The biologic explanation for this association is not clear yet.
By Abigail Zuger, MD
January 10, 2006
Covering:
Dial S et al., JAMA 2005 Dec 21; 294:2989-95
Ez-HBT Test for H. pylori Eradication
Gastroenterology Summary and Comment
A simple blood test might be suitable to verify <$EMPH_O>H. pylori<$EMPH_C> eradication in some clinical settings.
By David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
January 3, 2006
Covering:
Ahmed F et al., Aliment Pharmacol Ther 2005 Nov 1; 22:875-80
