Trends in Upper and Lower Gastrointestinal Bleeding and Perforation
Gastroenterology Summary and Comment
During the past decade, peptic ulcer bleeding and perforation decreased while colonic diverticular and angiodysplasia bleeding increased.
Helicobacter pylori Infection and Barrett Esophagus
Gastroenterology Summary and Comment
<$EMPH_O>H. pylori<$EMPH_C> infection, chronic gastritis, and intestinal metaplasia were each inversely associated with Barrett esophageal metaplasia.
Peptic Ulcer Disease in China
Gastroenterology Summary and Comment
PUD and <$EMPH_O>Helicobacter pylori<$EMPH_C> infection are common in Shanghai; most affected individuals are asymptomatic.
Functional Dyspepsia and Quality of Life
Gastroenterology Summary and Comment
Somatization and psychosocial factors were major risk factors for impaired QOL.
Predicting Response to Proton-Pump Inhibitors for Dyspepsia
Gastroenterology Summary and Comment
The value of a therapeutic index to predict response is unclear.
Upper Gastrointestinal Bleeding Incidence and Mortality
Gastroenterology Summary and Comment
Case fatality rates declined in Wales from 1999 to 2007, but incidence remained the same.
Budesonide for Eosinophilic Esophagitis
Gastroenterology Summary and Comment
Short-term administration of the topical corticosteroid budesonide was highly effective in treating EoE and relieving its symptoms.
By David A. Johnson, MD
January 28, 2011
Covering:
Straumann A et al., Gastroenterology 2010 Nov; 139:1526
Are Proton-Pump Inhibitors Safe During Early Pregnancy?
Gastroenterology Summary and Comment
Free
In a large cohort study, use of PPIs during the first trimester did not increase risk for major birth defects.
By David A. Johnson, MD
January 21, 2011
Covering:
Pasternak B and Hviid A., N Engl J Med 2010 Nov 25; 363:2114
Mitchell AA., N Engl J Med 2010 Nov 25; 363:2161
Is Endoscopy Safe for Pregnant Women with Upper Gastrointestinal Bleeding?
Gastroenterology Summary and Comment
Pregnant women were less likely than nonpregnant women to undergo endoscopy for nonvariceal UGIB; however, endoscopy was not associated with adverse maternal or fetal outcomes.
Selective Serotonin Reuptake Inhibitors and Peptic Ulcers
Gastroenterology Summary and Comment
People with uncomplicated ulcers were 50% more likely to be using SSRIs, suggesting a possible direct ulcerogenic effect.
Can Aspirin-Phosphatidylcholine Reduce Aspirin-Induced Ulcers?
Gastroenterology Summary and Comment
Use of a novel formulation of aspirin resulted in fewer ulcers or erosions.
Does Blood Type Affect Risk for Gastric Cancer and Peptic Ulcers?
Gastroenterology Summary and Comment
Blood type A was associated with gastric cancer; blood type O was associated with peptic ulcers.
Proton-Pump Inhibitors Safe During Early Pregnancy
Women's Health Summary and Comment
Free
First-trimester exposure to PPIs — and use of omeprazole within the month before pregnancy — did not significantly raise risk for major congenital birth defects.
By Wendy S. Biggs, MD
December 2, 2010
Covering:
Pasternak B and Hviid A., N Engl J Med 2010 Nov 25; 363:2114
Mitchell AA., N Engl J Med 2010 Nov 25; 363:2161
Smoking Clearly Linked to Esophageal Adenocarcinoma
Tobacco use is a significant contributor to the increasing prevalence of this disease.
Proton-Pump Inhibitor Therapy for Postnasal Drainage?
Gastroenterology Summary and Comment
Lansoprazole outperformed placebo, reviving old questions about silent gastroesophageal reflux disease and extraesophageal reflux.
Risk Factors for UGI Events in NSAID Users
Gastroenterology Summary and Comment
Significant predictors included a prior upper gastrointestinal event, low-dose aspirin use, older age, and corticosteroid use.
PPIs for Laryngopharyngeal Reflux?
Gastroenterology Summary and Comment
Free
A close look at findings from a randomized, placebo-controlled trial show that the proton-pump inhibitor rabeprazole provided benefit in treating gastroesophageal — but not laryngopharyngeal — symptoms.
By David A. Johnson, MD
November 12, 2010
Covering:
Lam PKY et al., Clin Gastroenterol Hepatol 2010 Sep; 8:770
Vaezi MF., Clin Gastroenterol Hepatol 2010 Sep; 8:741
Do Proton-Pump Inhibitors Cause Microscopic Colitis?
Gastroenterology Summary and Comment
Free
Small studies suggest a link, but the body of research is still inconclusive.
Does Helicobacter pylori Infection Increase Bleeding in Patients Taking Aspirin?
Gastroenterology Summary and Comment
The research is still inconclusive.
Historical Trends in Gastric Cancer and Peptic Ulcer Disease
Gastroenterology Summary and Comment
Risks for these diseases peaked among people born shortly before the turn of the twentieth century and then declined in subsequent generations.
Treatment for Peptic Ulcer Hemorrhage: How Much Variation?
Gastroenterology Summary and Comment
Free
Most endoscopists in the U.S. seem to be complying with practice guidelines.
False-Positive Cytology for Endoscopic Ultrasound Fine-Needle Aspiration
Gastroenterology Summary and Comment
It's much more common than you might have thought.
By Stuart Sherman, MD
September 17, 2010
Covering:
Gleeson FC et al., Gut 2010 May; 59:586
Video Capsule Endoscopy for Patients with Upper Gastrointestinal Bleeding
Gastroenterology Summary and Comment
VCE screening accurately identified high-risk patients and shortened their wait times for urgent endoscopy but at what cost?
Gastroprotection for Orthopedic Trauma Patients
Gastroenterology Summary and Comment
An educational awareness program improved adherence to guidelines about the use of gastroprotective agents.
Treating Adults Patients with Eosinophilic Esophagitis
Gastroenterology Summary and Comment
Free
Long-term data provide insights about esophageal dilation and other care strategies.
